Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia

Henao, Sandra Lorena Duque; Urrego, Sergio; Cano, Andrea M; Higuita, Edwin Andrés

doi:10.1615/intjmedmushrooms.2018026986

Cited by 19 publications

(20 citation statements)

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“…The present study shows that daily consumption of a combination of elderberry and reishi extracts during the winter season is effective in reducing the duration and severity of respiratory infections in elderly people. Several clinical studies have shown the beneficial immunological effect of elderberry [12,13] and reishi [24], but to our knowledge, this is the first study that evaluated the combined effect of both extracts on the incidence, severity, and duration of respiratory infections in older adults, a population group at increased risk of this type of infection and a worse prognosis of the disease [5].…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the reishi (Ganoderma lucidum), it has been observed in vitro and in animal studies that the triterpenoids contained in the reishi exert anti-influenza activity by neuraminidase inhibition [35,36]. Moreover, a recent clinical study reported that a yogurt enriched with β-glucans from reishi increased the absolute count of peripheral blood total lymphocytes (CD3 + , CD4 + , and CD8 + T cells) compared to a nonenriched yogurt in a group of healthy children [24]. Therefore, the results achieved in this randomized clinical trial could be related to the observed immunomodulatory and antiviral activities of elderberry and reishi.…”

Section: Discussionmentioning

confidence: 99%

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Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial

et al. 2020

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Elderly people are particularly vulnerable to respiratory tract infections, so natural strategies to ameliorate the duration and severity of these infections are of great interest in this population. The objective of this study is to evaluate the efficacy of the consumption of a combination of elderberry and reishi extracts on the incidence, severity, and duration of respiratory tract infections in a group of healthy elderly volunteers. A randomized, double-blind, placebo-controlled pilot study was performed during the winter season. A group of 60 nursing home residents ≥65 years of age was randomly assigned to receive a combination of 1.5 g of elderberry +0.5 g of reishi or a placebo daily for 14 weeks. Data about the health conditions of the volunteers were evaluated and recorded by a medical doctor every 2 weeks. The incidence of respiratory infections was similar in both groups. However, volunteers in the extract group presented a significantly lower duration of common cold events (2.5 vs. 4.8 days, p = 0.033).and a significantly lower probability of having a high severity influenza-like illness event (p = 0.039). Moreover, the incidence of sleep disturbances was significantly lower in the extract group (p = 0.049). Therefore, the administration of a combination of elderberry and reishi extracts to the elderly population during the winter season might be used as a natural strategy to reduce the duration and severity of respiratory tract infections.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial

et al. 2020

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“…Multiple myeloma patients receiving a combination of extracts of AB, GF, and Hericium erinaceus exhibited an increase in regulatory T cells and plasmacytoid dendritic cells, while concentrations of pro-inflammatory cytokines (IL-6, TNFα) did not change significantly when compared to placebo (Tangen et al, 2015). Healthy children receiving β-glucan (isolated from GL) in yoghurt showed significantly higher levels of circulating CD8+ T cells without a significant increase in cytokines IL-1β, IL-6, IL-10, IL-12, and TNF-α (Henao, Urrego, Cano, & Higuita, 2018). A small study evaluating immune cell function in patients with myelodysplastic syndromes showed improved neutrophil and monocyte function in those patients receiving a GF extract compared to a placebo group, although cytokine concentrations were not assessed (Wesa et al, 2015).…”

Section: Medicinal Mushrooms and Fungal Preparationsmentioning

confidence: 94%

Botanical drugs and supplements affecting the immune response in the time of COVID‐19: Implications for research and clinical practice

Brendler

Al‐Harrasi

Bauer

et al. 2020

Phytotherapy Research

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In times of health crisis, including the current COVID‐19 pandemic, the potential benefit of botanical drugs and supplements emerges as a focus of attention, although controversial efficacy claims are rightly a concern. Phytotherapy has an established role in everyday self‐care and health care, but, since botanical preparations contain many chemical constituents rather than single compounds, challenges arise in demonstrating efficacy and safety. However, there is ample traditional, empirical, and clinical evidence that botanicals can offer some protection and alleviation of disease symptoms as well as promoting general well‐being. Newly emerging viral infections, specifically COVID‐19, represent a unique challenge in their novelty and absence of established antiviral treatment or immunization. We discuss here the roles and limitations of phytotherapy in helping to prevent and address viral infections, especially regarding their effects on immune response. Botanicals with a documented immunomodulatory, immunostimulatory, and antiinflammatory effects include adaptogens, Boswellia spp., Curcuma longa, Echinacea spp., Glycyrrhiza spp., medicinal fungi, Pelargonium sidoides, salicylate‐yielding herbs, and Sambucus spp. We further provide a clinical perspective on applications and safety of these herbs in prevention, onset, progression, and convalescence from respiratory viral infections.

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“…The use of β-glucan from Ganoderma lucidum mushrooms as part of therapeutic yogurt allows for protecting the body of children aged 3–5 years from infectious diseases [ 72 ], and its consumption in the amount of 1% with Plukenetia volubilis seeds in yogurt based on skimmed milk powder significantly improves organoleptic properties, even though there was some reduction in rheological characteristics [ 113 ]. This dose allows to simulate the presence of fat in yogurt and brings it closer to the control sample in terms of taste perception.…”

Section: The Use Of β-Glucan In the Technology Of Dairy Drinks And Fe...mentioning

confidence: 99%

β-Glucan as a Techno-Functional Ingredient in Dairy and Milk-Based Products—A Review

et al. 2022

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The article systematizes information about the sources of β-glucan, its technological functions and practical aspects of its use in dairy and milk-based products. According to the analysis of scientific information, the main characteristics of β-glucan classifications were considered: the source of origin, chemical structure, and methods of obtention. It has been established that the most popular in the food technology of dairy products are β-glucans from oat and barley cereal, which exhibit pronounced technological functions in the composition of dairy products (gel formation, high moisture-binding capacity, increased yield of finished products, formation of texture, and original sensory indicators). The expediency of using β-glucan from yeast and mushrooms as a source of biologically active substances that ensure the functional orientation of the finished product has been revealed. For the first time, information on the use of β-glucan of various origins in the most common groups of dairy and milk-based products has been systematized. The analytical review has scientific and practical significance for scientists and specialists in the field of food production, in particular dairy products of increased nutritional value.

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Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia

Cited by 19 publications

References 0 publications

Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial

Effects of a Combination of Elderberry and Reishi Extracts on the Duration and Severity of Respiratory Tract Infections in Elderly Subjects: A Randomized Controlled Trial

Botanical drugs and supplements affecting the immune response in the time of COVID‐19: Implications for research and clinical practice

β-Glucan as a Techno-Functional Ingredient in Dairy and Milk-Based Products—A Review

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