Randomized clinical trial of Chinese herbal medications to reduce wound complications after mastectomy for breast carcinoma

Chen, J.; Lv, Qing; Yu, Miao; Zhang, X.; Gou, Jing

doi:10.1002/bjs.7227

Cited by 19 publications

(10 citation statements)

References 15 publications

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“…Danshen is a very commonly used Chinese herbal medicine for cardiovascular conditions [ 180 , 181 , 182 ]. In a clinical trial, this herbal medicine has been shown to be effective in reducing skin flap ischemia and necrosis after mastectomy [ 183 ]. The effects of antiplatelet aggregation of Danshen have been reported from a number of investigations.…”

Section: Resultsmentioning

confidence: 99%

Commonly Used Dietary Supplements on Coagulation Function during Surgery

2015

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Background Patients who undergo surgery appear to use dietary supplements significantly more frequently than the general population. Because they contain pharmacologically active compounds, dietary supplements may affect coagulation and platelet function during the perioperative period through direct effects, pharmacodynamic interactions, and pharmacokinetic interactions. However, in this regard, limited studies have been conducted that address the pharmacological interactions of dietary supplements. To avoid possible bleeding risks during surgery, information of potential complications of dietary supplements during perioperative management is important for physicians. Methods Through a systematic database search of all available years, articles were identified in this review if they included dietary supplements and coagulation/platelet function, while special attention was paid to studies published after 1990. Results Safety concerns are reported in commercially available dietary supplements. Effects of the most commonly used natural products on blood coagulation and platelet function are systematically reviewed, including 11 herbal medicines (echinacea, ephedra, garlic, ginger, ginkgo, ginseng, green tea, kava, saw palmetto, St John’s wort, and valerian) and 4 other dietary supplements (coenzyme Q10, glucosamine and chondroitin sulfate, fish oil, and vitamins). Bleeding risks of garlic, ginkgo, ginseng, green tea, saw palmetto, St John’s wort, and fish oil are reported. Cardiovascular instability was observed with ephedra, ginseng, and kava. Pharmacodynamic and pharmacokinetic interactions between dietary supplements and drugs used in the perioperative period are discussed. Conclusions To prevent potential problems associated with the use of dietary supplements, physicians should be familiar with the perioperative effects of commonly used dietary supplements. Since the effects of dietary supplements on coagulation and platelet function are difficult to predict, it is prudent to advise their discontinuation before surgery.

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Section: Resultsmentioning

confidence: 99%

Commonly Used Dietary Supplements on Coagulation Function during Surgery

2015

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“…For example, Sui and Zhang [33] reported that there were a number of participants with xerostomia for both groups injected with anisodamine. Also, two other studies [20, 21] that administered anisodamine for their pharmacopuncture group reported AEs such as xerostomia along with hot flashes and blurred vision, which are all commonly known AEs of anisodamine itself [48, 49]. This can be suggesting that those AEs may be caused by the drug itself and not by the modality of pharmacopuncture.…”

Section: Discussionmentioning

confidence: 99%

Pharmacopuncture for Cancer Care: A Systematic Review

Cheon

Zhang

Lee

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Background. Pharmacopuncture, injection to acupoints with pharmacological medication or herbal medicine, is a new acupuncture therapy widely available in Korea and China for cancer-related symptoms. However, the evidence is yet to be clear. Objective. To determine pharmacopuncture's effectiveness on cancer-related symptoms. Methods. Eleven databases were searched for randomized controlled trials of pharmacopuncture in cancer patients. The Cochrane risk of bias (ROB) assessment tool was used for quality assessment. Results. Twenty-two studies involving 2,459 patients were included. Five trials of chemotherapy-induced nausea and vomiting (CINV) underwent meta-analysis. Pharmacopuncture significantly relieved severity of CINV compared with control group (3 trials, risk ratio (RR) 1.28, 95% confidence interval (CI) = 1.14–1.44). The frequency of CINV was also significantly reduced with pharmacopuncture (2 trials, RR 2.47, 95% CI = 2.12–2.89). Seventeen trials studied various symptoms, and in most studies, pharmacopuncture significantly relieved pain, ileus, hiccup, fever, and gastrointestinal symptoms and improved quality of life in various cancer patients. ROB was generally high. Conclusion. It may be suggested with caution that pharmacopuncture may help various symptom relief in cancer patients, but it is hard to draw a firm conclusion due to clinical heterogeneity and high ROB of the included studies, hence warranting further investigation.

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“…One study indicated that injection of S. miltiorrhiza and ligustrazine can effectively reduce myocardial damage in patients with severe burns [19]. Animal studies also indicate that S. miltiorrhiza enhances the wound healing process [20,21]. Randomized clinical trial of S. miltiorrhiza suggested that it is effective in reducing skin flap ischaemia necrosis after mastectomy [20].…”

Section: Discussionmentioning

confidence: 99%

“…Animal studies also indicate that S. miltiorrhiza enhances the wound healing process [20,21]. Randomized clinical trial of S. miltiorrhiza suggested that it is effective in reducing skin flap ischaemia necrosis after mastectomy [20]. S. miltiorrhiza can stimulate the cell proliferation and it has the potential to be used for wounding healing or cosmetic treatment [22].…”

Section: Discussionmentioning

confidence: 99%

Ectopic expression of human acidic fibroblast growth factor 1 in the medicinal plant, Salvia miltiorrhiza, accelerates the healing of burn wounds

Tan

Wang

et al. 2014

BMC Biotechnol

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BackgroundHealing of burns is a complex process and very few effective treatments exist to facilitate the burn recovery process. Human acidic fibroblast growth factor 1 (FGF-1) plays an important role in a variety of biological processes, including angiogenesis, and tissue repair. Salvia miltiorrhiza is widely used in traditional Chinese medicine as an herb for the treatment of various diseases, including cardiovascular and cerebrovascular diseases, and traumatic injuries. We present that expression of FGF-1 in S. miltiorrhiza significantly accelerates the healing of burn wounds.ResultsThe human fgf-1 gene was fused with a barley α-amylase signal peptide DNA sequence and driven by a 35S promoter for constitutive expression in transgenic S. miltiorrhiza plants. The highest yield of recombinant FGF-1 obtained from leaves of transgenic S. miltiorrhiza lines was 272 ng/fresh weight. Aqueous extracts from transgenic S. miltiorrhiza exhibited FGF-1 activity approximately 19.2-fold greater than that of the standard FGF-1. Compared to the standard FGF-1 or the extracts obtained from non-transgenic plants, it stimulated proliferation of Balb/c 3 T3 mouse fibroblast cells assessed with the standard MTT assay and promoted angiogenesis in the chicken embryo chorioallantoic membrane (CAM) assay. Topical application of the extract significantly accelerated the burn wound healing process.ConclusionsThe product appears to retain the biological activity of both FGF-1 as well as the medicinal properties of the plant. The extracts from transgenic S. miltiorrhiza combines the therapeutic functions of FGF-1 and the medicinal plant, S. miltiorrhiza. Topical application of the product can reduce the costs associated with extraction, purification, and recovery.

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Randomized clinical trial of Chinese herbal medications to reduce wound complications after mastectomy for breast carcinoma

Abstract: Anisodamine and S. miltiorrhiza were both effective in reducing skin flap ischaemia and necrosis after mastectomy, although anisodamine was associated with a higher rate of adverse effects.

Cited by 19 publications

References 15 publications

Commonly Used Dietary Supplements on Coagulation Function during Surgery

Commonly Used Dietary Supplements on Coagulation Function during Surgery

Pharmacopuncture for Cancer Care: A Systematic Review

Ectopic expression of human acidic fibroblast growth factor 1 in the medicinal plant, Salvia miltiorrhiza, accelerates the healing of burn wounds

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