Randomized clinical trial of laparoscopic <i>versus</i> open donor nephrectomy

Nicholson, Michael L.; Kaushik, Monika; Lewis, G; Brook, Nicholas R.; Bagul, Atul; Kay, Mark; Harper, S.; Elwell, R; Veitch, P. S.

doi:10.1002/bjs.6803

Cited by 131 publications

(83 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, graft survival is 5% more in LDN compared with ODN. Although, this is not clinically significant, long-term follow-up of 2 other RCTs carried out by Nicholson and associates 13 and Dolsand associates 14 were 5% superior in LDN when compared with ODN. Greco and associates published a systematic review after analysis of more than 50 comparative studies about the different techniques of donor nephrectomy (open, laparoscopy, hand-assisted laparoscopy) according to perioperative parameters and graft outcome, and concluded that even though WITs are longer in the laparoscopic group, postoperative graft function was not significantly different between these 3 modalities.…”

Section: Discussionmentioning

confidence: 66%

Long-Term Graft Function in a Randomized Clinical Trial Comparing Laparoscopic Versus Open Donor Nephrectomy

Simforoosh¹,

Basiri²,

Shakhssalim³

et al. 2012

Exp Clin Transplant

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 66%

Long-Term Graft Function in a Randomized Clinical Trial Comparing Laparoscopic Versus Open Donor Nephrectomy

Simforoosh¹,

Basiri²,

Shakhssalim³

et al. 2012

Exp Clin Transplant

View full text Add to dashboard Cite

“…Other approaches such as advances in surgical techniques can encourage and improve living donation concept. The development of laparoscopic nephrectomy was a tremendous advance because it decreased disfigurement and reduced pain and time to recovery [78].…”

Section: Policies To Enhance Living Donationmentioning

confidence: 99%

Live Donor Kidney Transplantation Pearls: A Practical Review

Matter¹,

Abbas²,

Nagib³

et al. 2017

UNOAJ

View full text Add to dashboard Cite

Living donation is "a gift of extraordinary value". The use of living donors for renal transplantation was critical for the early development of the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipient, but there are an increasing percentage of cases, where donors are genetically unrelated like spouses, friends, or other emotionally related individuals. Ethical guidelines mandate that the living donors should not be coerced without any evidence of financial profit for the donor. Living donation has been associated with a higher success rate than that seen with cadaveric donation. Conclusion:In view of higher demand for transplantation and the lack of a parallel increase in the number of available cadaveric organs, living donation is important solution for patients to avoid long times on waiting list, and occasionally, even the need of dialysis so, much efforts are needed to encourage living donation rates.

show abstract

“…14 While in recent literature the intraoperative complication rate has been found to be greater in patients undergoing more conventional open approaches, 15 a number of earlier reports have suggested the opposite to be true. Other studies have also reported no appreciable differences in complications between either approach.…”

Section: Mini-open Vs Laparoscopic Nephrectomy For Kidney Transplantmentioning

confidence: 99%

“…22 Laparoscopic donors also benefit from a reduced hospital LOS that has been well-documented in the literature. [14][15][16][18][19][20][23][24][25] Despite the shorter hospital stay, the higher cost of surgical equipment needed for laparoscopy leads to a higher overall cost when compared to mini-ODN ($5132 vs. rampersad et al…”

Section: Mini-open Vs Laparoscopic Nephrectomy For Kidney Transplantmentioning

confidence: 99%

Back-to-back comparison of mini-open vs. laparoscopic technique for living kidney donation

Rampersad

Patel

Koulack

et al. 2016

CUAJ

View full text Add to dashboard Cite

Introduction: Laparoscopic living donor nephrectomy is the standard of care at high-volume renal transplant centres, with benefits over the open approach well-documented in the literature. Herein, we present a retrospective analysis of our single-institution donor nephrectomy series comparing the mini-open donor nephrectomy (mini-ODN) to the laparoscopic donor nephrectomy (LDN) with regards to operative, donor, and recipient outcomes. Methods: From 2007-2011, there were 89 cases of mini-ODN, at which point our centre transitioned to LDN; 94 cases were performed from 2011-2014. In total, 366 patients were reviewed, including donor and recipient pairs. Donor and recipient demographics, intraoperative data, postoperative donor recovery, recipient graft outcomes, and financial cost were assessed comparing the surgical approaches. Results: We demonstrate a reduced estimated blood loss (347.83 vs. 90.3 cc), lower intraoperative complication rate (4 vs. 11) and shorter length of hospital stay (2.4 vs. 3.3 days) for patients in the LDN group. Operative time was significantly longer for the LDN group (108.4 vs. 165.9 minutes), although this did not translate to a longer warm ischemia time (mean 2.0 minutes for each group). The rate of delayed graft function and recipient 12-month creatinine were comparable for ODN and LND. Overall cost of LDN was $684 higher for an uncomplicated admission. Conclusions: Despite a longer surgical time and higher upfront cost, our study supports that LDN yields several advantages over the mini-ODN, with a lower estimated blood loss, fewer intraoperative complications, and shorter length of hospital stay, all while maintaining excellent renal allograft outcomes.

show abstract

Randomized clinical trial of laparoscopic versus open donor nephrectomy

Abstract: LDN removes some of the disincentives to live donation without compromising the outcome of the recipient transplant.

Cited by 131 publications

References 20 publications

Long-Term Graft Function in a Randomized Clinical Trial Comparing Laparoscopic Versus Open Donor Nephrectomy

Long-Term Graft Function in a Randomized Clinical Trial Comparing Laparoscopic Versus Open Donor Nephrectomy

Live Donor Kidney Transplantation Pearls: A Practical Review

Back-to-back comparison of mini-open vs. laparoscopic technique for living kidney donation

Contact Info

Product

Resources

About