Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer

Suwiński, Rafał; Bańkowska-Woźniak, Magdalena; Majewski, Wojciech; Idasiak, Adam; Maciejewski, Adam; Ziółkowska, Ewa; Windorbska, Wiesława; Składowski, Krzysztof; Miszczyk, Leszek; Maciejewski, Bogusław

doi:10.1016/j.radonc.2008.02.009

Cited by 31 publications

(46 citation statements)

References 17 publications

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“…6 The results of this trial have shown a non-significant trend towards improvement in locoregional control in a whole group of 279 patients. A significant improvement in locoregional tumour control attributable to acceleration of p-CAIR was, however, demonstrated in a subgroup of 121 patients with cancer of the oropharynx/oral cavity.…”

Section: Introductionmentioning

confidence: 87%

“…It may also support an inference which suggests that unduly short interval surgery-radiotherapy may be detrimental, just as unduly prolonged is. 3,6 Weight loss was related to irradiated volume; volume did not, however, affect the maximum severity score of mucosal reactions. Peak severity score may, thus, not precisely reflect the overall impact of mucositis since the score may be high, even though the affected area is small.…”

Section: Acute Mucosal Reactionsmentioning

confidence: 95%

“…This may improve locoregional tumour control by hampering tumour repopulation that can be triggered by cell depletion from surgery and successive fractions of radiotherapy. 3 The outcome of these trials is largely conflicting, with some of them demonstrating a significant improvement in locoregional control that favours accelerated p-CAIR, 4 some demonstrating a non-significant trend towards such improvement, 5,6 with others showing no beneficial effect of accelerated p-CAIR. 7,8 Such disparity can be explained by the relatively small sample size of these trials, heterogeneity in patient selection criteria, diversity in dose-fractionation schedules and in time interval surgery-radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Randomized clinical trial on 7-days-a-week post-operative radiotherapyvsconcurrent post-operative radiochemotherapy in locally advanced cancer of the oral cavity/oropharynx: a report on acute normal tissue reactions

Suwiński

Woźniak

Misiołek

et al. 2016

BJR

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Section: Introductionmentioning

confidence: 87%

Section: Acute Mucosal Reactionsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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Randomized clinical trial on 7-days-a-week post-operative radiotherapyvsconcurrent post-operative radiochemotherapy in locally advanced cancer of the oral cavity/oropharynx: a report on acute normal tissue reactions

Suwiński

Woźniak

Misiołek

et al. 2016

BJR

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“…Altered fractionation (AF) treatments have been widely studied in HNC to minimize the effect of tumor repopulation [17,18,19,20]. They are based on the radiobiological concept of increasing the tumor control rate when the same dose is delivered over a shorter time; AF consists of shortening RT duration or increasing the total RT dose, leaving the treatment time unchanged, in order to counteract tumor cell repopulation.…”

Section: State Of the Artmentioning

confidence: 99%

“…Patients who benefit more from adjuvant therapies are those with high-risk features [5,9,10,11,12,13,14,15,16,17,18,19,20,21]. …”

Section: State Of the Artmentioning

confidence: 99%

Postoperative Therapy in Head and Neck Cancer: State of the Art, Risk Subset, Prognosis and Unsolved Questions

et al. 2011

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Head and neck cancer may be easily controlled at early stages, but resectable locally advanced disease often relapses at T and N sites. Therefore, adequate adjuvant treatment is of crucial importance for improving local control and/or survival. Unfortunately, little data are available on the adjuvant setting. Adjuvant radiotherapy is regarded as a standard approach for patients with locally advanced radically resected head and neck cancer, while postoperative chemotherapy alone cannot be considered outside of clinical trials. However, chemoradiotherapy is widely considered superior to radiotherapy in patients at a high risk of relapse and may be considered the standard treatment in this population. In this respect, in the last few decades, there has been a growing interest due to the emerging data on both tumor biology and clinical trials. Several pathological and molecular factors, affecting behavior and head and neck cancer prognosis, could allow for a better selection of postoperative treatment. More recently, new prognostic and predictive factors were identified, including biomolecular aspects, human papillomavirus infection and lifestyle. The integration of these new factors deserves dedicated clinical studies, but the available knowledge already allows some deductive hypotheses. We performed a review of the literature to analyze the role of therapy in the postoperative setting and to discuss both the possibility of a different approach to each class of risk and the unsolved question for which randomized trials are warranted.

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Association of Survival With Shorter Time to Radiation Therapy After Surgery for US Patients With Head and Neck Cancer

Harris

Chen

Orosco

et al. 2018

JAMA Otolaryngol Head Neck Surg

164

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Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer

Cited by 31 publications

References 17 publications

Randomized clinical trial on 7-days-a-week post-operative radiotherapyvsconcurrent post-operative radiochemotherapy in locally advanced cancer of the oral cavity/oropharynx: a report on acute normal tissue reactions

Randomized clinical trial on 7-days-a-week post-operative radiotherapyvsconcurrent post-operative radiochemotherapy in locally advanced cancer of the oral cavity/oropharynx: a report on acute normal tissue reactions

Postoperative Therapy in Head and Neck Cancer: State of the Art, Risk Subset, Prognosis and Unsolved Questions

Association of Survival With Shorter Time to Radiation Therapy After Surgery for US Patients With Head and Neck Cancer

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