Randomized clinical trial on the effect of fibrin sealant on latissimus dorsi donor-site seroma formation after breast reconstruction

Llewellyn-Bennett, Rebecca; Greenwood, Rosemary; Benson, John R.; English, Rachel; Turner, J.; Rayter, Zenon; Winters, Zoë

doi:10.1002/bjs.8874

Cited by 34 publications

(31 citation statements)

References 22 publications

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“…At the latissimus dorsi harvest site during breast reconstruction following mastectomy, two papers support its use [181, 182] in conjunction with quilting sutures and two papers suggest that it does not work when used alone [183, 184]. In a single center nonrandomized sequential trial of using fibrin sealant alone ( n = 25) versus quilting sutures with sprayed fibrin sealant ( n = 21) conducted over a period of 5 months, significant reductions in the incidence of seroma (76% versus 42.9%, P = 0.022), seroma volume (median 30, range 20.0–46.7 versus median 45.0, range 25.0–160.0 mL, P = 0.043), total drainage (median 754.8, range 623.7–925.2 versus median 1,228.6, range 824.2–2,078.0 mL, P = 0.002), indwelling period of drainage (12.1 ± 3.9 versus 15.8 ± 5.9 mL, P = 0.01), and frequency of aspiration (4.8% versus 12%, P = 0.043) was found in favor of using quilting sutures and fibrin sealant [181].…”

Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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Background. Fibrin sealant became the first modern era material approved as a hemostat in the United States in 1998. It is the only agent presently approved as a hemostat, sealant, and adhesive by the Food and Drug Administration (FDA). The product is now supplied as patches in addition to the original liquid formulations. Both laboratory and clinical uses of fibrin sealant continue to grow. The new literature on this material also continues to proliferate rapidly (approximately 200 papers/year). Methods. An overview of current fibrin sealant products and their approved uses and a comprehensive PubMed based review of the recent literature (February 2012, through March 2013) on the laboratory and clinical use of fibrin sealant are provided. Product information is organized into sections based on a classification system for commercially available materials. Publications are presented in sections based on both laboratory research and clinical topics are listed in order of decreasing frequency. Results. Fibrin sealant remains useful hemostat, sealant, and adhesive. New formulations and applications continue to be developed. Conclusions. This agent remains clinically important with the recent introduction of new commercially available products. Fibrin sealant has multiple new uses that should result in further improvements in patient care.

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Section: Most Frequent Fibrin Sealant Clinical Literature Applicatmentioning

confidence: 99%

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

2014

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“…Jandali et al (8) apply muscle-sparing latissimus dorsi myocutaneous flaps for the treatment of axillary hidradenitis in order to reduce the donor site morbidity. LlewellynBennett et al (12) make use of fibrin sealant to avoid seroma formation at the donor site. Better aesthetic result at this area can be achieved by endoscopically assisted LDF harvesting (17).…”

Section: Discussionmentioning

confidence: 99%

Application of the pedicled m. latissimus dorsi flap for trunk reconstructions

Yankov

Zayakova

Hristov

et al. 2013

SSM

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PURPOSE: M. latissimus dorsi flap is one of the most commonly used pedicled flaps in plastic surgery. It can be based either on the dominant thoracodorsal vessels, or, as a reverse flap, on its secondary segmental pedicles. The purpose of this paper is to evaluate our experience with pedicled flaps from m. latissimus dorsi for trunk reconstructions. MATERIAL AND METHODS:In the present study, we applied eight flaps on 7 patients: four flaps for breast reconstruction, one flap for postmastectomy radiation wound treatment, one flap to cover a defect on the anterior thoracic wall caused by toxic skin necrosis, one flap to correct axillary skin contracture after deep burn injury, and one for lumbar reconstruction after malignant melanoma radical excision. RESULTS: In the present paper, two cases with application of this flap were reported to illustrate the stages of the surgical technique. All the flaps were vital and adapted normally. Narrow partial skin necrosis and donor scar depression were observed in the largest skin-muscle flap only. CONCLUSION: M. latissimus dorsi pedicled flaps are reliable source for trunk reconstructions. They may transfer abundant plastic material to compensate tissue deficit of different etiology. The risk of complications is insignificant, whereas the patients' quality of life is considerably improved.

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“…FSs are being explored for anal fistula closure, adhesion prevention, seroma reduction, as well as urologic, vascular, intestinal and nerve anastomoses [20,[36][37][38][39][40][41][42][43]. The adhesive properties are being exploited as an alternative fixation technique in various hernia repairs, as a means of pain reduction from reduced suture or tack placement, or for pain reduction after plastic surgical procedures [44][45][46][47][48][49][50].…”

Section: Expert Opinionmentioning

confidence: 99%

Fibrin sealants: surgical hemostat, sealant and adhesive

Mandell

Gibran

2014

Expert Opinion on Biological Therapy

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Randomized clinical trial on the effect of fibrin sealant on latissimus dorsi donor-site seroma formation after breast reconstruction

Abstract: This randomized study, which was powered for size effect, failed to show any benefit from fibrin sealant in minimizing back seromas after LD procedures.

Cited by 34 publications

References 22 publications

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Fibrin Sealant: The Only Approved Hemostat, Sealant, and Adhesive—a Laboratory and Clinical Perspective

Application of the pedicled m. latissimus dorsi flap for trunk reconstructions

Fibrin sealants: surgical hemostat, sealant and adhesive

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