2016
DOI: 10.3168/jds.2015-10775
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Randomized, controlled clinical trial on the efficacy of nonsteroidal antiinflammatory drugs for the treatment of acute puerperal metritis in dairy cows

Abstract: The objective of this study was to assess the efficacy of ketoprofen compared with ceftiofur hydrochloride for the treatment of acute puerperal metritis (APM). Specifically, we set out to compare the incidence of extended treatment (extT) between treatment groups, to determine the prevalence of purulent vaginal discharge (PVD) and milk yield on the first 3 milk tests postpartum, and to analyze reproductive performance of cows treated with ketoprofen or ceftiofur. Cows with rectal temperature ≥39.5°C and reddis… Show more

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Cited by 22 publications
(21 citation statements)
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“…On the other hand, there have also been reports of varying degrees of effectiveness of alternative drugs or agents for the prevention and treatment of metritis. These include probiotics usage [124], bacteriophages [79], non-steroidal anti-inflammatory drugs [125], botanical essential oils [126], Sheng Hua Tang [127], and chitosan microparticles (CMs) [116,128,129]. For example, it has been demonstrated that the intrauterine administration of CMs can be a viable alternative to traditional antibiotics for the prevention of metritis [128] as well as their effectiveness against the treatment of bacterial infections in animals [130].…”
Section: Antibioticsmentioning
confidence: 99%
“…On the other hand, there have also been reports of varying degrees of effectiveness of alternative drugs or agents for the prevention and treatment of metritis. These include probiotics usage [124], bacteriophages [79], non-steroidal anti-inflammatory drugs [125], botanical essential oils [126], Sheng Hua Tang [127], and chitosan microparticles (CMs) [116,128,129]. For example, it has been demonstrated that the intrauterine administration of CMs can be a viable alternative to traditional antibiotics for the prevention of metritis [128] as well as their effectiveness against the treatment of bacterial infections in animals [130].…”
Section: Antibioticsmentioning
confidence: 99%
“…The use of nonsteroidal anti-inflammatory drugs (NSAID) has been studied as a supportive treatment (Drillich et al, 2007) or as the first treatment option (Pohl et al, 2016) for metritis. Although NSAID did not seem to improve reproductive efficiency or milk production when used in combination with systemic antimicrobials (Drillich et al, 2007), they reduced the number of animals that required systemic antimicrobials when used as the first treatment choice (Pohl et al, 2016). However, the most important benefit of using NSAID could be to improve animal well-being during a painful and stressful disease (Laven et al, 2012).…”
Section: Other Nonantimicrobial Treatmentsmentioning
confidence: 99%
“…The reduction in pain associated with using these products during routine husbandry procedures is well documented, [6][7][8][9] and there is increasing evidence to support the benefits in painful diseases as well, including lameness, 10 mastitis 11 and metritis. 12 Cattle are naturally stoical animals, and while there are a number of pain assessment tools available for research, the use of analgesics in cattle relies heavily on the recognition and perception of pain by both producers and prescribing veterinarians. A previous large-scale survey evaluating the attitudes of UK cattle practitioners to pain and the use of analgesics identified that pain scores for different conditions varied markedly between individuals, with significant effects of gender and decade of graduation.…”
Section: Introductionmentioning
confidence: 99%
“…Numerous analgesic and anaesthetic products are available and licensed for use in farm animals, including non‐steroidal anti‐inflammatory drugs (NSAIDs) and local anaesthetics. The reduction in pain associated with using these products during routine husbandry procedures is well documented, 6–9 and there is increasing evidence to support the benefits in painful diseases as well, including lameness, 10 mastitis 11 and metritis 12 …”
Section: Introductionmentioning
confidence: 99%