1995
DOI: 10.1001/jama.1995.03520370057037
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Randomized Controlled Trial of 3 vs 10 Days of Trimethoprim/Sulfamethoxazole for Acute Maxillary Sinusitis

Abstract: At the 2-week follow-up, clinical symptoms and radiograph scores improved equally following 3 or 10 days of TMP/SMX plus oxymetazoline nasal spray. Symptomatic relapse and recurrence were similar between groups. Three days of antibiotics were as effective as 10 days and, because of the high disease prevalence, hold the potential for substantial cost savings.

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Cited by 87 publications
(34 citation statements)
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“…An early study of the use of trimethoprim-sulfamethoxazole for 3 versus 10 days to treat sinusitis diagnosed on a clinical and radiographic basis showed similar clinical success rates (76% vs. 77%) [39]. However, that study was not based on results of cultures of sinus aspirates and probably contained cases of viral sinusitis.…”
Section: Management Of Sinusitis: a Continuing Challengementioning
confidence: 99%
“…An early study of the use of trimethoprim-sulfamethoxazole for 3 versus 10 days to treat sinusitis diagnosed on a clinical and radiographic basis showed similar clinical success rates (76% vs. 77%) [39]. However, that study was not based on results of cultures of sinus aspirates and probably contained cases of viral sinusitis.…”
Section: Management Of Sinusitis: a Continuing Challengementioning
confidence: 99%
“…lective prescription'' strategy is the option with the lowest costs per cured patient. This enhances the decision to prescribe short regimens (18), or cheap antibiotics, which are equally effective in the treatment of acute sinusitis (12). If the costs of being symptomatic are higher than DFL548 per week, a ''selective prescription'' strategy is the option with the lowest costs per cured patient.…”
Section: Discussionmentioning
confidence: 99%
“…Publication guidelines are often referred to as checklists, since like other such documents they serve the function of "aides memoires," which have proven valuable in managing information in complex systems 10 . Rigid or mechanical application of checklists can of course prevent users from making sense of complex information 11,12 , but, paradoxically, checklists, like all constraints, can also serve as a crucial driver for creativity. The SQUIRE guidelines must therefore always be understood and used as signposts, not shackles 13 .…”
Section: Informal Feedbackmentioning
confidence: 99%