Randomized Controlled Trial of Chlorhexidine Dressing and Highly Adhesive Dressing for Preventing Catheter-related Infections in Critically Ill Adults

Abstract

A large randomized trial demonstrated that chlorhexidine-gel-impregnated dressings decreased the CRI rate in patients in the ICU with intravascular catheters. Highly adhesive dressings decreased dressing detachment but increased skin and catheter colonization. Clinical trial registered with www.clinicaltrials.gov (NCT 01189682).

Chlorhexidine gluconate or polyhexamethylene biguanide disc dressing to reduce the incidence of central-line-associated bloodstream infection: a feasibility randomized controlled trial (the CLABSI trial)

“…For example Timsit et al found a similar CHG-related contact dermatitis rate of 1.1% (5.3 per 1000 catheters) among critically ill patients. 21 We also found that reactions to the commonly used polyurethane dressing were 12 times more likely than reactions to the CHG disc dressing. This result differed from the findings of a systematic review of CHG discs used in the prevention of catheter related infections in newborns, where 19 (2.3%) infants in the chlorhexidine disc dressing group developed contact dermatitis compared M A N U S C R I P T…”

A 4-arm randomized controlled pilot trial of innovative solutions for jugular central venous access device securement in 221 cardiac surgical patients

“…Despite ubiquitous use, and importance to patients, limited research to date has focussed on dressing and securement products that prevent CVAD failure, with the only comprehensive work undertaken with chlorhexidine impregnated dressings [28,29]. Clinicians should be aware that the products they are currently using are unlikely to have been tested for effectiveness.…”

epic3: revised recommendation for intravenous catheter and catheter site care

“…Because occlusive dressings trap moisture on the skin and provide an ideal environment for the rapid growth of local microflora, dressings for insertion sites must be permeable to water vapour. 5 The two most common types of dressings used for insertion sites are sterile, transparent, semi-permeable polyurethane dressings coated with a layer of an acrylic adhesive ('transparent dressings') and gauze and tape dressings. Transparent dressings are permeable to water vapour and oxygen and impermeable to microorganisms.…”