“…Of the clinical trials, 37 were RCTs [15, 27–62], 10 were single-arm trials [63–72] and six were open-label extension studies [73–78]. The clinical trials included eight mirabegron studies [38, 43–45, 48, 58, 59, 61], six onabotulinumtoxinA studies [30, 35, 49, 53, 54, 74], 35 antimuscarinic studies [15, 27–29, 31–34, 36, 37, 39–42, 46, 50–52, 55, 56, 60, 62–73, 75, 76], two sacral nerve modulation studies [77, 78], one staged InterStim procedure study [57] and one study of foot reflexology [47].…”