Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee

Rindone, Joseph P.; Hiller, Debra; Collacott, Edward A.; Nordhaugen, Natalie; Arriola, Greg

doi:10.1136/ewjm.172.2.91

Cited by 113 publications

(56 citation statements)

References 12 publications

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“…In addition, the study was underpowered (Յ70 patients/group), and there were severe imbalances in patient characteristics at baseline (sex and disease severity) in favor of placebo. The trial by Rindone et al (24) was severely underpowered (Ͻ50 patients/group); it enrolled only men, who by the authors' admission, were older, heavier, had disease of longer duration, and had more severe radiographic changes than those in any other glucosamine studies. Fifty-seven percent of these patients were unresponsive to NSAIDs/analgesics, which were continued throughout the study.…”

Section: Heterogeneity and Quality In Oa/glucosamine Trialsmentioning

confidence: 99%

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

Reginster¹

2007

Arthritis & Rheumatism

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Section: Heterogeneity and Quality In Oa/glucosamine Trialsmentioning

confidence: 99%

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

Reginster¹

2007

Arthritis & Rheumatism

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“…The exceptions were Braham's [10] and Rindon's [27] studies in which the proportion of women was 28.3% and 5.1% correspondingly (Table 1). Women, particularly, those aged 55 years or above have a higher risk of developing knee OA, and more functional disabilities than men [28].…”

Section: Gender Difference Among the Participantsmentioning

confidence: 97%

“…Two had excluded present users of GlcN [25,27] and two others had set washout period for subjects with histories of GlcN consumption [32,33]. Based on the data from a long-term study [38], the change of Lequesne index after GlcN consumption was greater in the first year.…”

Section: History Of Glucosamine Usedmentioning

confidence: 99%

A review on the effects of glucosamine for knee osteoarthritis based on human and animal studies

Chan

2011

Hong Kong Physiotherapy Journal

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Glucosamine (GlcN) is a popular nutritional supplement/prescription for relieving symptoms of osteoarthritis (OA), particularly for the knee joint. Although there are certain studies reporting the positive effects of GlcN for OA, its use remains controversial and the mechanism behind is unclear. This article critically reviewed published papers on the effects of GlcN in human clinical trials and animal studies. Twelve human clinical studies were reviewed and half of the studies reported positive effects of GlcN for OA or regular knee pain. Eight animal studies were reviewed and most of them had involved histological examination of cartilage, glycosaminoglycan content, subchondral bone, and synovium. Besides, nociceptive behaviour, biochemical markers, and immunohistochemistry of the joints were also examined. There is some evidence showing the beneficial effects of GlcN on joint structural repair in animals, but further research is needed to confirm the applicability of these models in human.

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“…However, other RCTs showed that these therapies involving dietary supplements have not obtained significant results or more effective than placebo. 5,13,15,27 It is important to emphasize that many of these studies had limitations such as small samples, problems in the methods of allocation of the sample and methodological biases, which reduced the level of scientific evidence generated. 16,25 Chondroitin and glucosamine are dietary supplements sold without prescription and often without regulation and control over the quality of the substances.…”

Section: E4mentioning

confidence: 99%

“…The safety of these substances has been demonstrated in several studies, being inexistent or minimal the adverse effects such as gastrointestinal symptoms 12,24,27,31 and headaches. 13,17,24,27 Similar results were also obtained in control groups. Due to the safety of the structure-modifying agents, its indication can be useful even if the efficiency is low 16 .…”

Section: E4mentioning

confidence: 99%

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

Machado¹,

Machado²,

Cunali

2012

Dental Press J. Orthod.

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Introduction: Degenerative changes in Temporomandibular Joint (TMJ) have increased in prevalence and severity over the years. Within this context, it's necessary to obtain safe and effective therapies for control and management of the patient in cases of osteoarthritis and osteoarthrosis of the TMJ. Therapeutic options range from intra-articular infiltration protocols, occlusal splints, pharmacological therapies and physiotherapy and educational measures. The alternative treatment with structure-modifying agents, like as chondroitin and glucosamine sulphates, showed promising results, and especially safety. Thus, through a systematic literature review, this study aimed to analyze and discuss effectiveness and safety of chondroitin and glucosamine in degenerative changes of the TMJ.Methods: Survey in research bases MEDLINE, Cochrane, EMBASE, Pubmed, Lilacs and BBO, between the years of 1966 and January 2009, with focus in randomized clinical trial (RCTs) and quasi-randomized clinical trials, systematic reviews and meta-analysis. Results:After application of the inclusion criteria 2 articles were selected, both randomized controlled double-blind clinical trials, which evaluated the effectiveness of chondroitin and glucosamine in degenerative changes of the TMJ. Conclusions:There is the necessity of further RCT, with representative samples and long follow-up time, to obtainment more precise cause-effect relationships and to achieve an effective and objective protocol involving chondroitin and glucosamine in cases of degenerative changes of the TMJ. Introdução: as alterações degenerativas da Articulação Temporomandibular (ATM) têm aumentado em prevalência e em severidade ao longo dos anos. Dentro desse contexto, surge a necessidade de se obter terapêuticas efetivas e seguras para o controle e o manejo do paciente em situações de osteoartrite e osteoartrose da ATM. As opções terapêuticas variam desde protocolos de infiltrações articulares, dispositivos interoclusais, terapias farmacológicas e medidas fisioterápicas e educacionais. A alternativa de tratamento com agentes modificadores de estrutura -tais como o sulfato de condroitina e o sulfato de glicosamina -apresenta resultados promissores e, principalmente, seguros. KeywordsObjetivo: através de uma revisão sistemática da literatura, este trabalho teve como objetivo analisar e discutir a efetividade e a segurança da condroitina e da glicosamina nas alterações degenerativas da ATM.Métodos: levantamento nas bases de dados MEDLINE, Cochrane, Embase, PubMed, LILACS e BBO, no período compreendido entre 1966 e 2009, com enfoque em estudos clínicos randomizados (RCTs) e quase-randomizados, revisões sistemáticas e meta-análises.Resultados: após a aplicação dos critérios de inclusão, chegou-se a dois artigos (estudos clínicos randomizados controlados e duplo-cegos), que avaliaram a efetividade da condroitina e da glicosamina nas alterações degenerativas da ATM.Conclusão: existe a necessidade da realização de novos RCTs -com amostras representativas e tempo de acompanhament...

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Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee

Cited by 113 publications

References 12 publications

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

A review on the effects of glucosamine for knee osteoarthritis based on human and animal studies

Use of chondroitin sulphate and glucosamine sulphate in degenerative changes in TMJ: a systematic review

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