Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections

Williams, Kyle; Swedo, Susan E.; Farmer, Cristan; Grantz, Heidi; Grant, Paul; D’Souza, Precilla; Hommer, Rebecca; Katsovich, Liliya; King, Robert A.; Leckman, James F.

doi:10.1016/j.jaac.2016.06.017

Cited by 97 publications

(74 citation statements)

References 44 publications

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“…Recently a second double-blind study of intravenous immunoglobulin (IVIG) for OCD symptoms in PANDAS patients was published 86 . Unfortunately, although effects during the open label phase were substantial, there was little difference between the IVIG and control groups during the double-blind portion of the study.…”

Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2016

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2017

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Section: Resultsmentioning

confidence: 99%

Tourette syndrome research highlights from 2016

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2017

F1000Res

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“…Furthermore, treatment of PANDAS (described below) is not identical to OCD treatment. Prophylactic antibiotics or antibiotic treatment, anti-inflammatory treatment, and immunoglobulin, indicated in PANDAS treatment, are not prescribed in “idiopathic OCD” [118,120,121,122,123,124,125]. Therefore, it would be important to recognize and adequately treat PANDAS within a personalized medical setting.…”

Section: Infections and Ocdmentioning

confidence: 99%

“…Intravenous immunoglobulin (IVIG) could be an effective treatment [120,124,166] (Table 5); however, its effectiveness remains to be confirmed. Another treatment procedure studied was apheresis.…”

Section: Alternative Treatments For Ocdmentioning

confidence: 99%

Individualized Immunological Data for Precise Classification of OCD Patients

et al. 2018

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Obsessive–compulsive disorder (OCD) affects about 2% of the general population, for which several etiological factors were identified. Important among these is immunological dysfunction. This review aims to show how immunology can inform specific etiological factors, and how distinguishing between these etiologies is important from a personalized treatment perspective. We found discrepancies concerning cytokines, raising the hypothesis of specific immunological etiological factors. Antibody studies support the existence of a potential autoimmune etiological factor. Infections may also provoke OCD symptoms, and therefore, could be considered as specific etiological factors with specific immunological impairments. Finally, we underline the importance of distinguishing between different etiological factors since some specific treatments already exist in the context of immunological factors for the improvement of classic treatments.

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“…Sudden onset of symptoms after GAS pharyngitis usually presents. Diagnosis criteria for PANDAS; Pre-pubertal onset, sudden or episodic onset of symptoms, Hyperactivity, choreiform, or adventitious movements, Tics and/or OCD and Evidence of previous streptococcal infection [20,21].…”

Section: Autoimmune Neuropsychiatric Disorder Associated With Streptomentioning

confidence: 99%

“…Tonsillectomy failed to show clear benefit according to systemic review. Tonsillectomy should be considered according to current surgical guidelines [20][21][22]. There is lack of high level, long term studies about the management plan for PANS/PANDAS and no guidelines/agreed recommendations to be followed.…”

Section: Autoimmune Neuropsychiatric Disorder Associated With Streptomentioning

confidence: 99%

Upper Respiratory Tract Infections: Hidden Complications and Management Plan

Alsaeed¹

2017

JPNC

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The individual type of bacteria that causes bacterial URTI in a previously healthy child depends on: a. Immunization history.b. Previous antimicrobial therapy. AbstractUpper Respiratory Tract Infection (URTI) or acute nasopharyngitis is the most common disease in pediatrics. However, it is not always simple and transient as its causative pathogens are changing and challenging. Local and Systemic Septic complications of bacterial URTI are common and systemic aseptic complications of streptococcal nasopharyngitis are not uncommon. However, there is a great debate about the management plan because of two facts: It is the most common cause of antibiotic use and misuse [1] and all septic and aseptic complications are actually preventable if bacterial URTI was properly treated with antibiotics [2]. The aim of this article is to summarize facts about septic and aseptic complications of URTI and to illustrate the best management plan including wise use of antibiotics to save pediatric patients not only from overtreatment, but also from under treatment.

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Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections

Cited by 97 publications

References 44 publications

Tourette syndrome research highlights from 2016

Tourette syndrome research highlights from 2016

Individualized Immunological Data for Precise Classification of OCD Patients

Upper Respiratory Tract Infections: Hidden Complications and Management Plan

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