Randomized controlled trial of moderate cardiovascular exercise for patients with drug-resistant epilepsy

Åkerlund, Sara; Varkey, Emma; Klecki, Judith; Zelano, Johan; Ben‐Menachem, Elinor

doi:10.1016/j.yebeh.2021.108335

Cited by 16 publications

(19 citation statements)

References 31 publications

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“…17,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Diet interventions included ketogenic diet (n = 6), 17,27,29,33,37,38 modified Atkins diet (n = 9), 25,26,28,30,32,33,35,36,39 low glutamate diet (n = 1), 34 and low glycemic index therapy (n = 3). 26,31,37 Additional lifestyle interventions included physical activity (n = 9) [40][41][42][43][44][45][46] and sleep (n = 1). 47 A majority of study samples in this review included more males than females, with an average of 42% of females included in all studies.…”

Section: Overview Of Interventionsmentioning

confidence: 99%

“…The study sample age ranged from 11 months to 65 years. Most studies (n = 11) focused on adult (18-65) 29,30,32,33,[39][40][41][43][44][45][46] or pediatric or adolescent (3-17 years; n = 11). 17,25,28,31,[34][35][36][37][38]42,47 Two studies focused on infants (0-2 years).…”

Section: Overview Of Interventionsmentioning

confidence: 99%

“…17 Six studies focusing on PA included psychological well-being as an outcome of interest. [40][41][42][43][44][45][46] Three studies found that PA intervention did not significantly improve cognitive functioning. 40,42,45 The other 3 studies reported PA improved cognitive (Montreal cognitive assessment scores; P = .021), 43 verbal fluency and memory functioning (P < .05), 41 and stress levels (PSS-10; P = .045).…”

Section: Outcomes Of Interestmentioning

confidence: 99%

“…[40][41][42][43][44][45][46] Three studies found that PA intervention did not significantly improve cognitive functioning. 40,42,45 The other 3 studies reported PA improved cognitive (Montreal cognitive assessment scores; P = .021), 43 verbal fluency and memory functioning (P < .05), 41 and stress levels (PSS-10; P = .045). 44 The only sleep-based intervention did not report psychological outcomes.…”

Section: Outcomes Of Interestmentioning

confidence: 99%

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Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Sauls,

Buro,

Kirby

2024

Am J Health Promot

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Objective To gather and assess current literature on the prevalence and efficacy of lifestyle behavioral interventions (sleep, nutrition, physical activity) for health outcomes, including QOL, psychological well-being, behavioral changes, and seizure frequency, among PWE. Data Source A review was conducted of English-language articles identified from PubMed, Scopus, and Embase between January 2013 to January 2023. Study Inclusion and Exclusion Criteria Inclusion criteria were randomized controlled trials (RCT) with human subjects diagnosed with epilepsy who participated in a lifestyle behavioral intervention. Data Extraction Two researchers independently completed the title, abstract, and full-text reviews. Information extracted includes study population, duration, type of intervention, findings, and outcomes. Data Synthesis Data was narratively synthesized to show level of evidence and degree of consistency in findings. Results: 4001 studies identified, 66 full texts reviewed, and 24 included. A majority (n = 16) of studies utilized diet specific RCTs, and some focused on physical activity (n = 7) and sleep (n = 1). Diet-specific RCTs (eg, ketogenic, Modified Atkins) reported reduced seizure frequency with adverse effects, such as gastrointestinal complications. Physical activity-based interventions found that maintained levels of exercise improved QOL and psychological well-being. However, physical activity and diet-based interventions did not have lasting effects after study conclusion. Only the behavioral sleep intervention reported that sleep quality improved significantly and was maintained post-intervention. Conclusion Future research is needed to establish the relationship between lifestyle behavioral interventions on QOL and other health outcomes (eg, seizure frequency).

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Section: Overview Of Interventionsmentioning

confidence: 99%

Section: Overview Of Interventionsmentioning

confidence: 99%

Section: Outcomes Of Interestmentioning

confidence: 99%

Section: Outcomes Of Interestmentioning

confidence: 99%

See 2 more Smart Citations

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Sauls,

Buro,

Kirby

2024

Am J Health Promot

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“…The report categorized sports activities by level of risk of injury or death if a seizure occurs during the event, with low/no additional risk activities including dancing, golf, racquet sports, collective contact sports like judo or wrestling, and collective ground sports like baseball, basketball, field hockey, football or volleyball. Recent data have shown that a 6-month program of moderate intensity cardiovascular exercise performed at home using an ergometric bicycle for 30 min/day for 5 days/week significantly improved cardiovascular fitness without effecting seizure frequency of adults with drug-resistant epilepsy ( 41 ). Two other recent studies in adults with epilepsy showed health and cognitive benefits with a supervised exercise program that combined endurance and resistance training for either three 60-min sessions/week for 6 weeks ( 31 ) or two 60-min sessions/week for 12 weeks that also included stretching exercises ( 32 ).…”

Section: Cognitive Impairment and Physical Activity And Exercise In E...mentioning

confidence: 99%

Considering social determinants of health in the relationship between physical activity and exercise engagement and cognitive impairment among persons with epilepsy

Hansen

Allendorfer

2022

Front. Rehabilit. Sci.

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Many persons with epilepsy (PWE) are not as active or physically fit as compared to the general population. This lack of engagement in physical activity has been attributed to a number of factors, few of which take into consideration the social determinants of health (SDH). In this perspective, we highlight how SDH are considered in explaining lower levels of physical activity engagement among PWE, particularly for those experiencing cognitive impairment. We also discuss how these data can be applied in research to yield a greater impact on the quality of life among PWE. Consideration of SDH allows for increased understanding of how cognition can be both a determinant of physical activity and an outcome of environments conducive to physical activity in PWE.

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Proceedings of the 2022 “Lifestyle Intervention for Epilepsy (LIFE)” symposium hosted by Cleveland Clinic

Spurgeon,

Saper,

Alexopoulos

et al. 2024

Epilepsia Open

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Lifestyle interventions are strategies used to self‐manage medical conditions, such as epilepsy, and often complement traditional pharmacologic and surgical therapies. The need for integrating evidence‐based lifestyle interventions into mainstream medicine for the treatment of epilepsy is evident given that despite the availability of a multitude of treatments with medications and surgical techniques, a significant proportion of patients have refractory seizures, and even those who are seizure‐free report significant adverse effects with current treatments. Although the evidence base for complementary medicine is less robust than it is for traditional forms of medicine, the evidence to date suggests that several forms of complementary medicine including yoga, mindfulness meditation, cognitive behavioral therapy, diet and nutrition, exercise and memory rehabilitation, and music therapy may have important roles as adjuncts in the treatment armamentarium for epilepsy. These topics were discussed by a diverse group of medical providers and scientists at the “Lifestyle Intervention for Epilepsy (LIFE)” symposium hosted by Cleveland Clinic.Plain Language SummaryThere are many people with epilepsy who continue to have seizures even though they are being treated with medication or brain surgery. Even after seizures stop, some may experience medication side effects. There is research to suggest that certain lifestyle changes, such as yoga, mindfulness, exercise, music therapy, and adjustments to diet, could help people with epilepsy, when used along with routine treatment. Experts discussed the latest research at the “Lifestyle Intervention for Epilepsy (LIFE)” symposium hosted by Cleveland Clinic.

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Randomized controlled trial of moderate cardiovascular exercise for patients with drug-resistant epilepsy

Cited by 16 publications

References 31 publications

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Lifestyle Behavioral Interventions and Health-Related Outcomes Among People with Epilepsy: A Review of Randomized Controlled Trials

Considering social determinants of health in the relationship between physical activity and exercise engagement and cognitive impairment among persons with epilepsy

Proceedings of the 2022 “Lifestyle Intervention for Epilepsy (LIFE)” symposium hosted by Cleveland Clinic

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