RANDOMIZED DOUBLE BL IND STUDY COMPARING ONDANSETRON, PALONOS ETRON & GRANISETRON TO PREVE NT POST OPERATIVE NA USEA & VOMITING AFTE R LAPAROSCOPIC SURGERI ES UNDER GENERAL ANA ESTHESIA

Abstract

The aim of the study is to compare the efficacy of intravenously administered 5-HT3 receptor antagonists namely Ondansetron, Palonosetron and Granisetron given as prophylaxis for postoperative nausea and vomiting in patients undergoing laparoscopic surgeries under general anaesthesia. A single dose of palonosetron (0.75 µg) when given prophylactically results in a significantly lower incidence of PONV after laparoscopic surgeries than ondansetron (4mg) and granisetron (2.5mg) during the first 24 hours.