Randomized Double Blind Comparative Study on the Efficacy of Ibuprofen and Aceclofenac in Controlling Post-Operative Sequelae after Third Molar Surgery

Abstract

Objective To compare the efficacy of Ibuprofen and Aceclofenac in controlling pain, swelling and trismus following removal of impacted mandibular third molar teeth. To assess the patient's acceptability of these drugs. Methods The present double blind study was conducted on 60 adult patients for the surgical removal of impacted mandibular third molars. Drugs administered were Ibuprofen and Aceclofenac. Both the drugs were packed separately and coded with equal in number. After removal of impacted mandibular third molars, following parameters were studied: (1) Analgesic activity, (2) Maximum mouth opening, (3) Swelling. Results The scores were recorded preoperatively and on 1st, 3rd, 5th and 7th postoperative day. Conclusion Ibuprofen has a marginal edge over Aceclofenac. Both the drugs were well accepted by the patients with no reported adverse effects.

Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial

“…Extraction of impacted third molars is the most common surgical procedure in dentistry. [1][2][3][4][5] This procedure often involves soft tissue flaps and removal of bone tissue, and postoperative inflammation is sometimes accompanied by severe pain, edema, and limited mouth opening. 6,7 The symptoms resulting from surgical trauma after removal of third molars are therefore an excellent clinical model for studying acute pain, 4,5,[7][8][9][10][11] for which the efficacy of various commercially available therapeutic drugs 5,12 can be assessed.…”

“…4,7,10 Ibuprofen is an NSAID with analgesic and antipyretic properties, widely used in clinical practice because of its well-documented efficacy and safety compared with similar drugs. 1,16 It belongs to the class of derivatives of propionic acid, which reduce the biosynthesis of PGs and inhibit the migration of leukocytes, in addition to other functions. 15 Within the classification of anti-inflammatory drugs, ibuprofen belongs to the group of nonselective inhibitors of COX-1, an enzyme that confers protection to the gastric mucosa and renal tissues, and COX-2, an enzyme that contributes to the inflammatory process.…”

“…22 Therefore, corticosteroids used in pre-emptive analgesia are effective in delaying and preventing postoperative sequelae. 9,23 Although many studies have evaluated the postoperative action of ibuprofen and etodolac alone or in comparison with other types of drugs, 1,5,6,12,[14][15][16][17][18]21,22,[24][25][26][27] there have not yet been any studies evaluating the clinical pain control and anti-inflammatory postoperative benefits of ibuprofen and etodolac when used with pre-emptive analgesia with dexamethasone.…”

A parallel-group comparison study of celecoxib with loxoprofen sodium in third mandibular molar extraction patients

“…12,13 Unlike chronic pain, acute pain therefore requires rapid onset of the analgesic effect. The dose of celecoxib for acute pain such as that after tooth extraction is an initial dose of 400 mg followed by second and subsequent doses of 200 mg, a different dose from that used for chronic pain.…”

Comparison of Efficacy of Aceclofenac and Ibuprofen After Surgical Removal of Impacted Third Molar

“…induce vasodilatation and mediators that are responsible for increase in vascular permeability. 4 Surgical trauma initiates the peripheral inflammatory reaction, which is the cause for postoperative pain. Postoperative swelling might contribute to the postoperative pain, because of increased tension in the tissues.…”