Randomized, Double‐Blind Comparison of the Efficacy of Two Hyaluronic Acid Derivatives, Restylane Perlane and Hylaform, in the Treatment of Nasolabial Folds

Carruthers, Alastair; Carey, Wayne; Lorenzi, Claudio De; Remington, Kent; Schachter, Daniel; Sapra, Sheetal

doi:10.2310/6350.2005.31246

Cited by 110 publications

(88 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wrinkle grading systems of varying complexity have been validated for reproducibility and reliability and are used for assessing the efficacy of treatments such as botulinum toxin A injections 5,6 and hormone replacement therapy 7 and for the classification of facial wrinkles. 8 Other examples include the Wrinkle Severity Rating Scale (WSRS), which is a 5-grade assessment system of labial folds that was validated 9 and then applied in two studies to distinguish between two treatments for facial soft tissue augmentation, 10,11 and the Lemperle scale, which was used in a study (abstract presented in AAD, 2006, 12 to compare two treatments for nasolabial fold correction.…”

mentioning

confidence: 99%

The Modified Fitzpatrick Wrinkle Scale: A Clinical Validated Measurement Tool for Nasolabial Wrinkle Severity Assessment

Shoshani¹,

Markovitz²,

Monstrey

et al. 2008

Dermatol Surg

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

The Modified Fitzpatrick Wrinkle Scale: A Clinical Validated Measurement Tool for Nasolabial Wrinkle Severity Assessment

Shoshani¹,

Markovitz²,

Monstrey

et al. 2008

Dermatol Surg

View full text Add to dashboard Cite

show abstract

“…This could be a very useful value add on in a dental practice as these can prove to be very safe and effective instruments for rejuvenation of the peri-oral area besides improving the smile of the patient. A number of studies have been performed to evaluate the longevity and safety of fillers [2][3][4]. Ideal filler should be sterile, biodegradable, non-pyrogenic, viscoelastic, clear, colorless, homogenous gel filler.…”

Section: Discussionmentioning

confidence: 99%

“…NLF's extend from the side of the nose to the corner of the mouth and are often exaggerated early in the aging process [2]. There are a vast variety of hyaluronic acid fillers available in the market today for the same [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Patient Satisfaction with Hyaluronic Acid Fillers for Improvement of the Nasolabial Folds in Type IV & V Skin

Sood¹,

Nanda²

2011

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

“…Treatment-related adverse events tended to occur more frequently on the non-animal-stabilized filler treated site Treatment related [74] Prospective study (n = 248), 6 months follow-up Short-term complications were observed in more than half of the subjects. In 2 cases treatment of the adverse event was necessary Treatment related [75] Prospective study (n = 439), 6 months follow-up ‡, §…”

Section: Hyaluronic Acid (Cross-linked)mentioning

confidence: 99%

Clinical data on injectable tissue fillers: a review

Vries

Geertsma

2013

Expert Review of Medical Devices

View full text Add to dashboard Cite

Treatment with injectable tissue fillers for aesthetic purposes is increasingly popular. In parallel with this success, questions related to the safety of these treatments and the products involved are being raised more prominently. To gain insight in the safety aspects of injectable tissue fillers, we performed a literature review to collect studies reporting clinical data of injectable tissue fillers. We found several case reports where serious complications after more than three years are described. However, there are only a limited number of well-defined prospective clinical studies available with follow-up periods longer than three years. Furthermore, causes of complications, that is, treatment or product related, are often not specified in literature. Considering the intended functional period of fillers in combination with the known occurrence of long-term complications, there is a need for well-defined prospective clinical studies. In order to be able to discriminate between product failure (a product safety issue) or application methodology (a physician expertise or training issue), better identification of observed complications and whether they are product or treatment related, is needed. For the safe use of the fillers it is important that treatment with injectable tissue fillers is performed by a trained physician, who knows the product specifications and its applications. . Moreover, it is expected that due to increase in life expectancy, the demand for anti-aging treatments, like tissue augmentation with injectable tissue fillers, will grow [2]. Their success has been attributed to the fact that treatments with injectable tissue fillers are fast and appear to be relatively easy [2]. Only a relatively 'simple' subcutaneous injection is needed. Today, various injectable tissue fillers with different characteristics are available, for example, duration of the effect, material type and intended anatomical location.Although the application of an injectable tissue filler seems to be relatively simple and safe, reports of serious adverse effects have appeared in the literature [2][3][4][5][6][7][8]. Estimates of the occurrence of severe complications after treatment with various types of injectable tissue fillers range between 1:80 and 1:50,000 patients [9,10]. Adverse side effects can be caused by incorrect injection techniques (treatment related) or by the characteristics of the products (product related) [11,12]. Short-, mid-and long-term complications can be discerned (TABLE 1) [2,13-15]. Short-term complications like pain, swelling, fever, immediate hypersensitivity reactions, occur immediately or within several days past treatment and disappear after several weeks. A more severe short-term complication is necrosis [5,16]. Necrosis occurs immediately or within a few days if blood vessels are obstructed by the filler material or if they are injured during the treatment [17]. Mid-term complications such as delayed inflammatory reactions, ulceration and granuloma reaction may occur after 2-12 months. I...

show abstract

Randomized, Double‐Blind Comparison of the Efficacy of Two Hyaluronic Acid Derivatives, Restylane Perlane and Hylaform, in the Treatment of Nasolabial Folds

Abstract: Restylane Perlane provides a more durable esthetic improvement than Hylaform and offers acceptable tolerability.

Cited by 110 publications

References 11 publications

The Modified Fitzpatrick Wrinkle Scale: A Clinical Validated Measurement Tool for Nasolabial Wrinkle Severity Assessment

The Modified Fitzpatrick Wrinkle Scale: A Clinical Validated Measurement Tool for Nasolabial Wrinkle Severity Assessment

Patient Satisfaction with Hyaluronic Acid Fillers for Improvement of the Nasolabial Folds in Type IV & V Skin

Clinical data on injectable tissue fillers: a review

Contact Info

Product

Resources

About