Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity  - FLAVO Study -

Takahira, Masaya; Noda, Kohei; Fukushima, Mikio; Zhang, Bo; Mitsutake, Ryoko; Uehara, Yoshio; Ogawa, Masahiro; Kakuma, Tatsuyuki; Saku, Keijiro

doi:10.1253/circj.cj-10-1013

Cited by 23 publications

(27 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are in line with several previous RCTs [19, 21, 33–35] in which soy protein has no better effect on body weight and composition than milk or animal products. A 12-month RCT [34] among older postmenopausal women (60–75 y) reported that 25.6 g soy protein containing 99 mg isoflavones had no effect on BMI and WHR compared with milk protein.…”

Section: Discussionsupporting

confidence: 93%

“…Women at different menopausal stages may response differently to soy supplementation; however, our subgroup analysis among women in early menopause (<4 years) did not suggest a different effect compared with women in late menopause. Another 20-week RCT [19] even reported that formula food containing milk protein is superior to that containing soy protein for reducing visceral and subcutaneous fat. A 23-week RCT [20] also indicated that whey protein but not soy protein supplementation alters body weight and composition in overweight and obese adults.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension

Liu

Chen

et al. 2013

Journal of Obesity

View full text Add to dashboard Cite

Objectives. This paper reported the effects of commonly used whole soy foods (soy flour) and purified daidzein (one of the major isoflavones and the precursor of equol) on changes in anthropometric measurements and body composition in a 6-month double-blind, randomized, placebo-controlled trial among prehypertensive postmenopausal women who are also equol producers. Methods. 270 eligible women were randomized to either one of the three treatments: 40 g soy flour (whole soy group), 40 g low-fat milk powder + 63 mg daidzein (daidzein group), or 40 g low-fat milk powder (placebo group) daily each for 6 months. Anthropometric indicators and body composition were measured before and after intervention. Results. 253 subjects completed the study with good compliance. Urinary isoflavones levels suggested good compliance of subjects with supplementation. Whole soy and purified daidzein had no significant effect on body weight, body mass index (BMI), waist and hip circumferences, waist to hip ratio (WHR), body fat percentage, fat mass, and free fat mass. Conclusion. Six-month consumption of whole soy and purified daidzein at provided dosage had no improvement on body weight and composition compared with isocaloric milk placebo among prehypertensive equol-producing postmenopausal women. This trial is registered with ClinicalTrials.gov NCT01270737.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension

Liu

Chen

et al. 2013

Journal of Obesity

View full text Add to dashboard Cite

show abstract

“…For example, postmenopausal obese women consuming a calorie-restricted diet supplemented with soy protein did not lose significantly more weight compared to a diet without soy [146]. Another RCT revealed that soy protein was not as effective as milk protein in lowering visceral and subcutaneous fat mass [147], and postmenopausal women did not experience significant reductions in BMI or waist-to-hip ratio after consuming isoflavone-rich soy protein daily for 12 months [148]. However, the addition of black soy protein led to more significant declines in body weight, body fat mass and leptin in 64 overweight/obese participants [149], and in a 12-month exercise and nutrition intervention study, obese women lost significantly more body weight with a soy yogurt meal replacement compared to control [150].…”

Section: Interventional Studies Involving Soymentioning

confidence: 99%

Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

et al. 2017

View full text Add to dashboard Cite

The hypocholesterolemic effect of soy is well-documented and this has led to the regulatory approval of a health claim relating soy protein to a reduced risk of cardiovascular disease (CVD). However, soybeans contain additional components, such as isoflavones, lecithins, saponins and fiber that may improve cardiovascular health through independent mechanisms. This review summarizes the evidence on the cardiovascular benefits of non-protein soy components in relation to known CVD risk factors such as hypertension, hyperglycemia, inflammation, and obesity beyond cholesterol lowering. Overall, the available evidence suggests non-protein soy constituents improve markers of cardiovascular health; however, additional carefully designed studies are required to independently elucidate these effects. Further, work is also needed to clarify the role of isoflavone-metabolizing phenotype and gut microbiota composition on biological effect.

show abstract

“…4−6 In further support of a fat-reducing effect of milk-proteins, a randomized controlled study with overweight subjects showed that intake of milk protein for 20 weeks reduced both visceral and subcutaneous fat more than intake of soy protein. 7 …”

Section: Introductionmentioning

confidence: 99%

Urinary Loss of Tricarboxylic Acid Cycle Intermediates As Revealed by Metabolomics Studies: An Underlying Mechanism to Reduce Lipid Accretion by Whey Protein Ingestion?

et al. 2014

View full text Add to dashboard Cite

Whey protein intake is associated with the modulation of energy metabolism and altered body composition both in human subjects and in animals, but the underlying mechanisms are not yet elucidated. We fed obesity-prone C57BL/6J mice high-fat diets with either casein (HF casein) or whey (HF whey) for 6 weeks. At equal energy intake and apparent fat and nitrogen digestibility, mice fed HF whey stored less energy as lipids, evident both as lower white adipose tissue mass and as reduced liver lipids, compared with HF-casein-fed mice. Explorative analyses of 48 h urine, both by 1H NMR and LC–MS metabolomic platforms, demonstrated higher urinary excretion of tricarboxylic acid (TCA) cycle intermediates citric acid and succinic acid (identified by both platforms), and cis-aconitic acid and isocitric acid (identified by LC–MS platform) in the HF whey, relative to in the HF-casein-fed mice. Targeted LC–MS analyses revealed higher citric acid and cis-aconitic acid concentrations in fed state plasma, but not in liver of HF-whey-fed mice. We propose that enhanced urinary loss of TCA cycle metabolites drain available substrates for anabolic processes, such as lipogenesis, thereby leading to reduced lipid accretion in HF-whey-fed compared to HF-casein-fed mice.

show abstract

Randomized, Double-Blind, Controlled, Comparative Trial of Formula Food Containing Soy Protein vs. Milk Protein in Visceral Fat Obesity - FLAVO Study -

Cited by 23 publications

References 24 publications

A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension

A Six-Month Randomized Controlled Trial of Whole Soy and Isoflavones Daidzein on Body Composition in Equol-Producing Postmenopausal Women with Prehypertension

Beyond the Cholesterol-Lowering Effect of Soy Protein: A Review of the Effects of Dietary Soy and Its Constituents on Risk Factors for Cardiovascular Disease

Urinary Loss of Tricarboxylic Acid Cycle Intermediates As Revealed by Metabolomics Studies: An Underlying Mechanism to Reduce Lipid Accretion by Whey Protein Ingestion?

Contact Info

Product

Resources

About