Randomized, double-blind, placebo-controlled clinical trial studying the effects of Turmeric in combination with mefenamic acid in patients with primary dysmenorrhoea

Hesami, Sepideh; Kavianpour, Maria; Nooshabadi, Mohammadreza Rashidi; Yousefi, Mojgan; Lalooha, Fatemeh; Haghighian, Hossein Khadem

doi:10.1016/j.jogoh.2020.101840

Cited by 12 publications

(15 citation statements)

References 19 publications

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“…In previous double‐blind, placebo‐controlled clinical trial turmeric supplementation (500 mg/5 days; pre and during the bleeding), might be more advantageous in lessen of the menstrual associated pain compared to conventional treatment, mefenamic acid (250 mg). Moreover, the combination of these two compounds is more efficient in PD patients (Hesami et al, 2020). Dyawapur et al reported that cinnamon tea and turmeric water were equally effective in alleviating of pain in girls with PD (Dyawapur et al, n.d.).…”

Section: Discussionmentioning

confidence: 99%

Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial

Bahrami

Zarban

Rezapour

et al. 2021

Phytotherapy Research

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Premenstrual syndrome (PMS) and primary dysmenorrhea are common complaints among young women. This study evaluated the effects of curcumin supplements on symptoms of pain in young women with PMS and dysmenorrhea. A randomized, triple-blinded, placebo-controlled clinical trial was undertaken. Women who suffered from both PMS and dysmenorrhea were enrolled, and were randomly allocated to the curcumin (n = 62), or placebo (n = 62) groups. Each subject received one capsule (500 mg of curcuminoid, or placebo) daily, from 7 days pre-until 3 days postmenstruation for three successive menstrual cycles. Participants recorded the severity of PMS, or dysmenorrhea using a Premenstrual Syndrome Screening Tool (PSST) and the visual analog scale, respectively. Baseline characteristics of participants did not differ between the curcumin and placebo groups. At the end of the trial, the PSST scores were significantly lower in both the curcumin (32.5 ± 9.8 vs. 21.6 ± 9.8); and placebo groups (31.7 ± 9.4 vs. 23.4 ± 12.8). There was a significant reduction of dysmenorrhea pain in both the curcumin and placebo groups (by 64% and 53.3%, respectively). Hence, curcumin had comparable effects as placebo, regarding the amelioration of symptoms of PMS and dysmenorrhea. Further studies are required with larger samples, using higher doses curcumin for longer durations, and perhaps in combination therapy.

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Section: Discussionmentioning

confidence: 99%

Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial

Bahrami

Zarban

Rezapour

et al. 2021

Phytotherapy Research

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“…A study was conducted to demonstrate the effect of turmeric alone and in combination with mefenamic acid in patients suffering from primary dysmenorrhea (PDM). It was concluded that the combination treatment effectively relieved the menstrual pain associated with PDM when taken for 5 days . Curcumin has also shown potential in mitigating the severity of postmenopausal symptoms.…”

Section: Clinical Trials Of Turmeric and Curcuminmentioning

confidence: 99%

“…It was concluded that the combination treatment effectively relieved the menstrual pain associated with PDM when taken for 5 days. 357 Curcumin has also shown potential in mitigating the severity of postmenopausal symptoms. For example, curcumin ameliorated PMS symptoms in terms of mood, behavior, and physical symptoms by modulating neurotransmitters and inducing an anti-inflammatory effect in patients taking 100 mg curcumin every 12 h for 7 days prior to the menstrual cycle and for 3 days into the cycle.…”

Section: Effects Of Turmeric and Curcumin On Gynecological Conditionsmentioning

confidence: 99%

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Kunnumakkara

Hegde

Dey

et al. 2023

ACS Pharmacol. Transl. Sci.

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Turmeric (Curcuma longa) has been used for thousands of years for the prevention and treatment of various chronic diseases. Curcumin is just one of >200 ingredients in turmeric. Almost 7000 scientific papers on turmeric and almost 20,000 on curcumin have been published in PubMed. Scientific reports based on cell culture or animal studies are often not reproducible in humans. Therefore, human clinical trials are the best indicators for the prevention and treatment of a disease using a given agent/drug. Herein, we conducted an extensive literature survey on PubMed and Scopus following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The keywords "turmeric and clinical trials" and "curcumin and clinical trials" were considered for data mining. A total of 148 references were found to be relevant for the key term "turmeric and clinical trials", of which 70 were common in both PubMed and Scopus, 44 were unique to PubMed, and 34 were unique to Scopus. Similarly, for the search term "curcumin and clinical trials", 440 references were found to be relevant, of which 70 were unique to PubMed, 110 were unique to Scopus, and 260 were common to both databases. These studies show that the golden spice has enormous health and medicinal benefits for humans. This Review will extract and summarize the lessons learned about turmeric and curcumin in the prevention and treatment of chronic diseases based on clinical trials.

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“…For example, NSAIDs have many side effects, including headaches, indigestion, and drowsiness. 5,6 Therefore, it becomes necessary to find new treatment strategies and complementary medicines.…”

Section: Introductionmentioning

confidence: 99%

“…For example, NSAIDs have many side effects, including headaches, indigestion, and drowsiness. 5,6 Therefore, it becomes Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review necessary to find new treatment strategies and complementary medicines.…”

Section: Introductionmentioning

confidence: 99%

Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review

Shabanian Boroujeni,

Heidari-Soureshjani,

Sherwin

2024

Journal of Endometriosis and Pelvic Pain Disorders

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Premenstrual syndrome (PMS) and dysmenorrhea, in addition to harming the physical and mental health of women, also disrupt their daily life and quality of life. We aimed to investigate the effects and underlying mechanisms of Curcuma longa (turmeric) and curcumin on PMS and dysmenorrhea. PRISMA guideline 2020 was followed for conducting this systematic review. Comprehensive literature searches were conducted across multiple databases, including PubMed, EMBASE, Web of Science, and Scopus. Finally, 17 articles were found after considering the study’s inclusion and exclusion criteria into account. Data were extracted and entered into an Excel file for further investigation and drew the results. Curcuma longa and curcumin affect PMS and dysmenorrhea through various mechanisms. They inhibit the activity of cyclooxygenase-2 (COX-2) and the production of prostaglandins, thus reducing inflammation and pain. Additionally, curcumin’s antioxidant properties protect against oxidative stress, and lipid peroxidation helps maintain hormonal balance, exert analgesic effects, and relieve the symptoms of PMS and dysmenorrhea. They also insert neurotransmitter modulatory properties, such as increased serotonin and dopamine levels, which may contribute to their antidepressant, and sedative effects. Curcuma longa and curcumin indicated promising therapeutic effects in reducing PMS and dysmenorrhea symptoms due to their anti-inflammatory and antioxidant effects. Although, further well-designed clinical trials are needed to establish their efficacy and optimal dosage.

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Randomized, double-blind, placebo-controlled clinical trial studying the effects of Turmeric in combination with mefenamic acid in patients with primary dysmenorrhoea

Cited by 12 publications

References 19 publications

Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial

Effects of curcumin on menstrual pattern, premenstrual syndrome, and dysmenorrhea: A triple‐blind, placebo‐controlled clinical trial

Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials

Effects of Curcuma longa (turmeric) and curcumin on the premenstrual syndrome and dysmenorrhea: A systematic review

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