Randomized, Double-Blind Trial of Lithostat™ (Acetohydroxamic
Acid) in the Palliative Treatment of Infection-Induced Urinary Calculi

Griffith, Donald P.; Gleeson, Malachy J.; Lee, Hui; Longuet, Roy; Deman, Esther; Earle, Nan

doi:10.1159/000471707

Cited by 146 publications

(61 citation statements)

References 12 publications

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“…In double-blind, placebo-controlled clinical trials, acetohydroxamic acid (Lithostat), a complete nonreversible urease inhibitor, was associated with 17-42% of stone growth versus 46-60% in patients treated with placebo. Side effects occurred in 45-68% of cases [19][20][21] . …”

Section: Treatmentmentioning

confidence: 99%

Stones and Urinary Tract Infections

Miano¹,

Germani²,

Vespasiani³

2007

Urol Int

116

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The term infection stones refers to calculi that occur following urinary tract infections (UTIs) caused by urease-producing gram-negative organisms. They consist of magnesium ammonium phosphate, carbonate apatite and monoammonium urate. Alkaline urine is most favorable to their formation. Urinary tract obstruction, neurogenic bladder, voiding dysfunction, temporary or indwelling urinary catheters, distal renal tubular acidosis and medullary sponge kidney are considered the main risk factors for developing infection stones. Urinalysis and urine culture are essential for diagnosis. A typical finding on imaging is a moderately radiopaque, staghorn or branched stone. Curative treatment is possible only by eliminating all of the stone fragments and by eradicating UTI. A variety of operative and pharmaceutical approaches is available. Metaphylactic treatment is mandatory to prevent recurrences. The relationship between urinary stones and UTIs is well known and shows two different clinical pictures: (1) stones that develop following UTIs (infection stones) which play a key role in stone pathogenesis, and (2) stones complicated by UTIs (stones with infection) which are metabolic stones that passively trap bacteria from coexistent UTIs and may consist of calcium or non-calcium. This article presents an overview of infection stones, analyzing the epidemiology, composition, pathogenesis, diagnosis, treatment and prevention of this type of calculi.

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Section: Treatmentmentioning

confidence: 99%

Stones and Urinary Tract Infections

Miano¹,

Germani²,

Vespasiani³

2007

Urol Int

116

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show abstract

“…The urease inhibitor acetohydroxamic acid (AHA) has been studied with limited success and not insignificant side effects. [151][152][153] This agent is not currently available in Canada. A better-tolerated prevention strategy may be low-dose suppressive antibiotic therapy, but the risk of bacterial resistance should be taken into consideration.…”

Section: Index Patient 5: Struvite Stonementioning

confidence: 99%

CUA guideline on the evaluation and medical management of the kidney stone patient ‒ 2016 update

Dion¹,

Ankawi²,

Chew³

et al. 2016

CUAJ

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“…Bu duruma gelen strüvit taşları "geyik boynuzu (staghorn)" taşları olarak adlandırılmaktadır. 57,58 İYE'ler taş oluşum riskini artırdığı için klinisyenin, enfeksiyonların neden olduğu taşlar ile üri-ner sistem taşlarına eşlik eden enfeksiyonu ayırdetmesi gerekmektedir; ancak bu ayrım kolay kolay yapılamamaktadır. Bununla birlikte taş analizi bu ayrımda yardımcı olabilmektedir.…”

Section: İdrar Yolu Enfeksiyonlarıunclassified

“…Bir üreaz inhibitörü olan asetohidroksamik asit eriş-kinlerde başarıyla kullanılıyorsa da çocuklarda ciddi yan etkileri nedeni ile kullanılmamalıdır. 58 Ç Çı ık ka ar r Ç Ça at tı ış şm ma as sı ı Yazarlar herhangi bir çıkar çatışması veya finansal destek bildirmemiştir.…”

Section: Si̇tratunclassified

Urolithiasis in Childhood: Review

Zeybek¹,

Orman²

2017

Turkiye Klinikleri J Pediatr

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Randomized, Double-Blind Trial of Lithostat™ (Acetohydroxamic Acid) in the Palliative Treatment of Infection-Induced Urinary Calculi

Cited by 146 publications

References 12 publications

Stones and Urinary Tract Infections

Stones and Urinary Tract Infections

CUA guideline on the evaluation and medical management of the kidney stone patient ‒ 2016 update

Urolithiasis in Childhood: Review

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