Randomized double‐blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging

Abstract

The trillion-dollar wellness industry is made up in large part of beauty and antiaging products, and continues to grow. 1-3 Currently, one of the main antiaging therapies involves the use of retinoids to treat wrinkles and pigmentation due to their ability to ameliorate hyperpigmentation and upregulate collagen. 4,5 Despite these therapeutic benefits, retinoids often have unwanted side effects such as scaling, itching, and redness. 6 The high rates of the use of retinoids and resulting side effects experienced by consumers

Open-Label Study to Evaluate the Efficacy of a Topical Anhydrous Formulation with 15% Pure Ascorbic Acid and Ginger as a Potent Antioxidant

“…The obtained results show that the addition of ginger to the formula enhances the effect of AA by three orders of magnitude compared to other tested combinations. Moreover, previous studies performed with ginger formulations demonstrated its efficacy in preventing cell damage and signs of cutaneous photoaging [24,25].…”

“…Both glutathione and ginger showed the best results for increasing the antioxidant effect of vitamin C + E (control). In light of these results, ginger was chosen as the best enhancer ahead of glutathione because of its complementary properties [24,25].…”

Clinical dermatologic applications of ginger: a focused review

“…Previous studies have identified MMPs as playing an important role in skin aging through the propagation of collagen breakdown 7 . More recently, a double‐blind randomized controlled study by Dhaliwal et al., 8 demonstrated a significant decrease in average wrinkle severity, total wrinkle volume, pigment intensity, and redness intensity in a group of patients who used 1% topical acetyl zingerone on the face twice daily for 8 weeks compared to a control group who applied a placebo. Lee et al., 9 examined the effects of zingerone on the properties of keratinocyte stems irradiated with UVB.…”

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“…This plants were used in cooking long time ago and also as a spice and traditional treatment like vomiting, nausea, pain, arthritis, indigestion, gastro reflux. 3 Moreover, many several uses of ginger tablet was useful in treating, managing, or preventing many diseases like cardiovascular disease, diabetes, 4 obesity, 6 respiratory disease, 5 nausea and vomiting induced by chemotherapy 7 and in neurodegenerative diseases; it also in-holds some of the biological properties like antimicrobial, 8 anti-inflammation, 9 antioxidant, 10 anticancer, 11 and wound healing properties. 12 In previous researches, there is different active contains of herbal medicinal plants showed different effective on poultry performance.…”