Randomized in vivo trial evaluating plaque inhibition benefits of an advanced stannous‐containing sodium fluoride dentifrice used in conjunction with power brush technology

Abstract

ObjectiveTo compare the plaque inhibition efficacy of a novel stannous-containing sodium fluoride test dentifrice to a standard anticavity negative control dentifrice, when both were used in conjunction with an advanced oscillating–rotating (O/R) power toothbrush.MethodsThis was a randomized, two-treatment, three-period, double-blind crossover study conducted in a population using an O/R power brush. Subjects brushed twice per day with their assigned dentifrice during the three-treatment periods, each lasting for 17 consecutive days. Each period was separated by a 4-day washout period during which subjects continued to use their O/R power toothbrush. Plaque levels were assessed and averaged amongst three assessments taken on days 15, 16 and 17 at the end of each treatment period using digital plaque imaging analysis. Assessments were carried out on the facial anterior tooth surfaces in the morning before brushing (A.M. prebrush) following whole-mouth brushing (30 s per quadrant) with the assigned dentifrice (A.M. post-brush) and in the afternoon (P.M.).ResultsTwenty-seven subjects were randomized and completed the study. During the 17-day usage period, the stannous-containing test NaF dentifrice demonstrated a statistically significant lower mean plaque area versus the negative control dentifrice at each assessment timepoint; overnight A.M. prebrush was 33.8% lower (P < 0.0001), A.M. post-brush was 21.8% lower (P < 0.01), and P.M. was 29.2% lower (P < 0.0001).ConclusionA population of O/R power toothbrush users had significantly less plaque coverage for all three measurements when using a stannous-containing NaF dentifrice than when using a negative control (fluoride) dentifrice.

What is the effect of active ingredients in dentifrice on inhibiting the regrowth of overnight plaque? A systematic review

“…In one study, the period of no oral hygiene extended to 12 hours and, in two other studies, to 24 hours . A fourth study used a power brush …”

“…The studies were carried out in several countries around the world, which included India, China, the UK and the United States …”

Effect of toothpaste containing amine fluoride and stannous chloride on the reduction of dental plaque and gingival inflammation. A randomized controlled 12‐week home‐use study

“…However, a few studies exist that investigated plaque inhibition. In comparison with sodium fluoride toothpastes, favourable immediate and overnight persisting antiplaque effects were detected in combination with manual or power brushing . After 17 days of product use, 22% more plaque was reduced with SnCl 2 /NaF toothpaste than with the negative control.…”

“…In comparison with sodium fluoride toothpastes, favourable immediate and overnight persisting antiplaque effects were detected in combination with manual or power brushing. 20,29 After 17 days of product use, 22% more plaque was reduced with SnCl 2 / NaF toothpaste than with the negative control. In comparison, we detected 12% plaque reduction after three weeks and 20% reduction after 12-week application of AmF/SnCl 2 .…”

Stabilized Stannous Fluoride Dentifrice as a Dental Plaque Inhibitor and an Antigingivitis Agent: Meta-Analysis

“…Szczotkowanie zę-bów prowadzono w okresach: 1 miesiąca, 6 tygodni, 3 miesięcy lub 6 miesięcy. Czasami wykorzystywano obrazowanie cyfrowe za pomocą DPIS ( Digital Plaque Imaging System) w celu porów-nania formowania się płytki nazębnej przez noc (pomiar ranny) lub 24 godziny później [11]. W ocenach klinicznych przeciwzapalnego dzia-łania tej pasty stosowano wskaźnik GI wg Löe i Silnessa [12], GBI wg Saxtona i van der Ouderaa [13] i najczęściej zmodyfikowany przez Lobene et al [14] wskaźnik dziąsłowy (MGI).…”