Randomized investigation of the bioavailability of fluoride in saliva after administration of sodium fluoride, amine fluoride and fluoride containing bioactive glass dentifrices

Naumova, Ella A.; Staiger, Moritz; Kouji, Ouafaa; Modric, Jakov; Pierchalla, T; Rybka, Maya; Hill, Robert G.; Arnold, Wolfgang H.

doi:10.1186/s12903-019-0805-6

Cited by 18 publications

(15 citation statements)

References 46 publications

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“…[97] In a more thorough study, the bioavailability of fluoride ions from F-containing bioglass was found to be equivalent to those present in high concentrations of sodium fluoride and amine fluoride. [98] Layered double hydroxides (LDHs) are ionic layers with positively-charged metal plates. The layered structure provides space for ion exchange and is used extensively in drug delivery systems.…”

Section: Fluoride Deliverymentioning

confidence: 99%

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Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow. For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved. New strategies for drug delivery have been investigated over the last decade to overcome these obstacles. Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues. Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches. The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine.

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Section: Fluoride Deliverymentioning

confidence: 99%

“…[ 97 ] In a more thorough study, the bioavailability of fluoride ions from F‐containing bioglass was found to be equivalent to those present in high concentrations of sodium fluoride and amine fluoride. [ 98 ]…”

Section: Ion Deliverymentioning

confidence: 99%

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

et al. 2021

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“…Therefore, the amount of FAP formed due to th limited bioavailability of fluoride is questionable. In F-BG toothpaste, fluoride is incor porated inside its glass composition, which possibly leads to its sustained release along with other useful ions such as calcium and phosphate [28,29], leading to the formation o…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the amount of FAP formed due to the limited bioavailability of fluoride is questionable. In F-BG toothpaste, fluoride is incorporated inside its glass composition, which possibly leads to its sustained release along with other useful ions such as calcium and phosphate [ 28 , 29 ], leading to the formation of FAP and a consequent increase in surface micro-hardness. Another aspect of our surface-microhardness results was the observance of reduced enamel micro-hardness post-demineralization for all the samples and an increase in the micro-hardness post-remineralization.…”

Section: Discussionmentioning

confidence: 99%

Enamel Remineralization Competence of a Novel Fluoride-Incorporated Bioactive Glass Toothpaste—A Surface Micro-Hardness, Profilometric, and Micro-Computed Tomographic Analysis

et al. 2021

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This study aimed to analyze the enamel remineralization efficacy of a novel fluoridated bioactive glass (F-BG) toothpaste compared to a standard fluoride toothpaste. Seventy-two enamel blocks (N = 72) were divided into groups of twenty-four blocks according to the toothpaste exposure—group 1: brushed with distilled water, group 2: brushed with fluoride toothpaste (ColgateTM), and group 3: brushed with F-BG toothpaste (BioMinFTM). Pre-brushing, enamel blocks were demineralized using 6 wt.% citric acid (pH = 2.4). Tooth brushing was performed using a mixture of respective toothpaste and artificial saliva (AS), and each enamel block received 5000 linear strokes. The samples were assessed for surface micro-hardness (to estimate Vickers hardness number, VHN), surface roughness (Ra), and volume loss/gain using micro-computed tomography (micro-CT). The highest increase in the VHN was noticed for group 3 (117.81) followed by group 2 (61.13), and all the intragroup comparisons were statistically significant (p < 0.05). Demineralization increased the Ra values, and a decrease was observed post-remineralization for all the groups. The maximum Ra decrease was observed for group 3 (−223.2 nm) followed by group 2 (−55.6 nm), and all the intragroup comparisons were again statistically significant (p < 0.05). Micro-CT investigation revealed that the enamel volume decreased after demineralization and increased after remineralization among all groups. The F-BG toothpaste showed greater enamel surface micro-hardness (increased VHN), smoother surface (low roughness), and better volume restoration (remineralization) in comparison to the fluoride toothpaste.

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“…Bioactive glasses (BAGs) are attractive additives for remineralizing toothpastes for treating dentine hypersensitivity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Dentine hypersensitivity is thought to occur as a result of fluid flow in open dentinal tubules that triggers nerves in the pulp chamber [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

A Potassium Based Fluorine Containing Bioactive Glass for Use as a Desensitizing Toothpaste

et al. 2021

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Potassium releasing bioactive glasses (BAGs) may offer improved relief for dentine hypersensitivity compared to conventional sodium containing BAGs by releasing K+ ions for nerve desensitization and occluding dentinal tubules to prevent fluid flow within dentinal tubules. Potassium oxide was substituted for sodium oxide on a molar basis in a fluoride containing BAG used in toothpastes for treating dentine hypersensitivity. The BAG powders were then immersed in an artificial saliva at pH 7 and tris buffer and the pH rise and ion release behavior were characterized by ICP-OES and ISE. The potassium and sodium containing BAGs were characterized by XRD, DSC, FTIR and NMR. Both BAGs presented amorphous diffraction patterns and the glass transition temperature of the potassium glass was higher than that of the sodium glass. The 31P MAS-NMR spectra indicated a peak at 2.7 ppm corresponding to apatite and a small peak at −103 ppm indicated crystallization to fluorapatite. Both BAGs dissolved and formed apatite at similar rates, although the dissolution of the potassium glass was slightly slower and it released less fluoride as a result of partial nanocrystallization to fluorapatite upon quenching. The potassium release from the potassium ions could potentially result in nerve deactivation when used in toothpastes.

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Randomized investigation of the bioavailability of fluoride in saliva after administration of sodium fluoride, amine fluoride and fluoride containing bioactive glass dentifrices

Cited by 18 publications

References 46 publications

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management

Enamel Remineralization Competence of a Novel Fluoride-Incorporated Bioactive Glass Toothpaste—A Surface Micro-Hardness, Profilometric, and Micro-Computed Tomographic Analysis

A Potassium Based Fluorine Containing Bioactive Glass for Use as a Desensitizing Toothpaste

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