Randomized Placebo-Controlled Trial of 60-Day Percutaneous Peripheral Nerve Stimulation Treatment Indicates Relief of Persistent Postoperative Pain, and Improved Function After Knee Replacement

Goree, Johnathan H.; Grant, Stuart A.; Dickerson, David M.; Ilfeld, Brian M.; Eshraghi, Yashar; Vaid, Sandeep; Valimahomed, Ali K.; Shah, Jarna R.; Smith, G. Lawson; Finneran, John J.; Shah, Nirav N.; Guirguis, Maged N.; Eckmann, Maxim S.; Antony, Ajay B.; Ohlendorf, Brian J.; Gupta, Mayank; Gilbert, John E.; Wongsarnpigoon, Amorn; Boggs, Joseph W.

doi:10.1016/j.neurom.2024.03.001

Cited by 2 publications

(1 citation statement)

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“…The PNS group also walked further in the 6 min walk test (47% vs. 9%, p = 0.048). This study suggests that PNS decreases persistent pain and improves functional outcomes, results similar to the studies mentioned in this systematic review [37]. In contrast, this study has more subjects and a more robust methodology.…”

Section: Discussionsupporting

confidence: 82%

The Relevance of Implanted Percutaneous Electrical Nerve Stimulation in Orthopedics Surgery: A Systematic Review

Parikh,

Echevarria,

Cemenski

et al. 2024

JCM

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Background: Percutaneous peripheral nerve stimulation (PNS) is a form of neuromodulation that involves the transmission of electrical energy via metal contacts known as leads or electrodes. PNS has gained popularity in orthopedic surgery as several studies have supported its use as a pain control device for patients suffering from pain due to orthopedic pathologies involving the knee, shoulder, and foot. The purpose of this systematic review is to summarize the literature involving peripheral nerve stimulation in orthopedic surgery. The existing body of literature provides support for further research regarding the use of PNS in the management of knee pain, hip pain, shoulder pain, foot pain, and orthopedic trauma. Notably, the evidence for its efficacy in addressing knee and shoulder pain is present. Methods: This study was conducted following PRISMA guidelines. Seven hundred and forty-five unique entries were identified. Two blinded reviewers assessed each article by title and abstract to determine its relevance and categorized them as “include”, “exclude”, and “maybe”. After a preliminary review was completed, reviewers were unblinded and a third reviewer retrieved articles labeled as “maybe” and those with conflicting labels to determine their relevance. Twenty-eight articles were included, and seven hundred and seventeen articles were excluded. Articles discussing the use of PNS in the field of orthopedic surgery in patients > 18 years of age after 2010 were included. Exclusion criteria included neuropathic pain, phantom limb pain, amputation, non-musculoskeletal related pathology, non-orthopedic surgery related pathology, spinal cord stimulator, no reported outcomes, review articles, abstracts only, non-human subjects. Results: A total of 16 studies analyzing 69 patients were included. All studies were either case series or case reports. Most articles involved the application of PNS in the knee (8) and shoulder (6) joint. Few articles discussed its application in the foot and orthopedic trauma. All studies demonstrated that PNS was effective in reducing pain. Discussion: Peripheral nerve stimulation can be effective in managing postoperative or chronic pain in patients suffering from orthopedic pathology. This systematic review is limited by the scarcity of robust studies with substantial sample sizes and extended follow up periods in the existing literature.

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Section: Discussionsupporting

confidence: 82%