Randomized Placebo-controlled Trial of Metronidazole 1% Cream with Sunscreen SPF 15 in Treatment of Rosacea

Tan, Jerry; Girard, C.; Krol, Alfons; Murray, H. Eileen; Papp, Kim; Poulin, Yves; Chin, Dora; Jeandupeux, D.

doi:10.1007/s10227-001-0144-4

Cited by 21 publications

(15 citation statements)

References 5 publications

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“…Metronidazole 1% cream, Metronidazole 0.75% gel, lotion and cream Topical metronidazole, available either as a gel or a cream, is the most popular topical agent for treating rosacea. Metronidazole 0.75% gel 22,[27][28][29] and metronidazole 1% cream, 14,23,25,[30][31][32][33][34][35][36][37] metronidazole 0.75% cream 35,38 and metronidazole lotion 39 have been shown to be effective in treating rosacea when applied once or twice daily for 8-12 weeks. The results of these studies have demonstrated that both preparations significantly decrease the number of inflammatory lesions and reduce the erythema associated with rosacea.…”

Section: Topical Treatmentsmentioning

confidence: 99%

Rosacea and its management: an overview

Gupta

Chaudhry

2005

Acad Dermatol Venereol

113

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Section: Topical Treatmentsmentioning

confidence: 99%

Rosacea and its management: an overview

Gupta

Chaudhry

2005

Acad Dermatol Venereol

113

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“…None of the studies met all the quality criteria. Thirteen (31%) studies were rated as ‘high quality’ [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13]. Of these, 12 were randomized and double-blinded studies and 1 was single-blinded and randomized.…”

Section: Resultsmentioning

confidence: 99%

“…Forty-two studies were included in this quality assessment evaluating the treatment of rosacea [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42]. The study design of these papers included 29 double-blind, 1 single-blind, and 9 open-labeled reports.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the Quality of Rosacea Studies: Implications for the Patient and Physician

Gupta

Chaudhry

2003

Dermatology

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Background: Patients suffering from rosacea may experience frequent blushing and flushing, erythema, telangiectasia, and/or rhinophyma. In an attempt to find effective treatments, many studies have been performed. Objective: It is important to be able to evaluate the quality of clinical trials where agents have been used to treat rosacea, and to compare the effectiveness of the different therapies used for this indication. Methods: The reports on the efficacy and safety of the different drug therapies were evaluated using predetermined criteria. We searched MEDLINE (1966–2002) for studies where rosacea was treated with the various therapies. The criteria used to assess the quality of the studies were: randomization, blinding (double, single, or open), aims clearly defined, prior sample size calculation, whether inclusion and/or exclusion criteria were outlined, baseline comparison of patient characteristics and demographics, interventions and efficacy parameters defined, compliance assessed, statistical analysis performed including intention-to-treat evaluation of efficacy of therapy. Results: Using the above-mentioned criteria, each study was rated in order to determine the quality of the clinical trial. The maximum score a study could attain was 20. To determine if high-quality studies are cited more often than the lower-quality papers, the number of times a study had been cited since its publication was measured. We found 13 of the 42 studies scored greater than 14; these studies were rated as high-quality studies. There was no significant association between high-quality papers and the number of times they had been cited, suggesting that other factors are also taken into consideration when a given study is cited. Conclusion: It is important for investigators and clinicians to be aware of the parameters that count towards designing a high-quality protocol since such studies are more likely to reflect efficacy rates that are accurate. Furthermore, it is essential that when a study is written up, the pertinent information regarding the design of the trial and the manner in which it was conducted are conveyed to the reader.

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“…Se encontraron 12 artículos; de los nueve ECA [12][13][14][15][16][17][18][19][20] , siete se consideraron de buena calidad 14-20 y dos de pobre calidad metodológica por fallas en el proceso de cegamiento, la asignación aleatoria o falta de informaron sobre las pérdidas de los pacientes 12,13 . En la mayoría de los estudios se evaluó la eficacia y la seguridad del metronidazol en la rosácea pápulo-pustular moderada a grave, y la efectividad en el eritema, y en solo dos estudios se evaluó la efectividad en las telangiectasias 14,16 .…”

Section: Metronidazol Tópico Vs Placebounclassified

“…De los dos estudios en que se evaluó la efectividad en las telangiectasias, en uno se encontró que las mejoraba en forma significativa con respecto al grupo control 16 , mientras que, en el otro no se encontró mejoría de las mismas 14 .…”

Section: Metronidazol Tópico Vs Placebounclassified

Guías clínicas para el tratamiento de la rosácea

Molina¹,

Londoño²,

Escobar³

et al. 2012

rev. asoc. colomb. dermatol. cir. dematol.

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ResumenLa rosácea es una condición inflamatoria crónica que afecta la piel y los ojos, caracterizada por eritema transitorio o persistente, pápulas y pústulas, y cuando está en etapas avanzadas, se presenta con "fimatosis". Existen múltiples modalidades terapéuticas para esta entidad, pero es poco claro cuál es la más efectiva. objetivo. Recolectar y analizar los diferentes estudios que hay en la literatura científica sobre el tratamiento de la rosácea y dar recomendaciones clínicas basadas en el nivel de evidencia. Métodos. La búsqueda de artículos sobre las diferentes modalidades de tratamiento de la rosácea pápulo-pustular, eritemato-telangiectásica y "fimatosa", se hizo en las bases de datos Embase, Medline, Lilacs, Ovid, con el buscador Pubmed, desde enero de 1980 hasta junio de 2011. Luego de recolectar la literatura científica disponible, se analizó la información y se calificó la calidad de los estudios utilizando las escalas de Jadad para ensayos clínicos de asignación aleatoria, y CASPE para estudios de casos y controles, cohortes y estudios cualitativos. Finalmente, se dan recomendaciones clínicas según el grado de evidencia encontrado. Resultados. Se encontraron 178 artículos de las diferentes modalidades terapéuticas. En la rosácea pápulo-pustular los tratamientos con mayor nivel de evidencia son el metronidazol, el ácido azelaico, la sulfacetamida y la doxiciclina; en la rosácea eritemato-telangiectásica, las modalidades más utilizadas son los medios físicos, y en la rosácea "fimatosa", el tratamiento de primera línea es el láser de CO 2 . Conclusiones. Este documento presenta una revisión actualizada de la literatura científica y formula recomendaciones terapéuticas basadas en el mejor nivel de evidencia que se encontró. Su implementación permitirá la unificación de criterios, con el objetivo de ofrecer un mejor tratamiento a los pacientes con la enfermedad.Palabras clave: rosácea, metronidazol, rayo láser. SummaryRosacea is a chronic inflammatory disease that affects the skin and the eyes. It is characterized by papules, pustules, persisting flushing and development of phymas. There are many different options of treatment but it is unclear which one is the most effective. objective: To recollect and to analyze all the available trials in dermatological Rev Asoc Colomb Dermatol Artículo de RevisiónRev Asoc Colomb Dermatol.

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Randomized Placebo-controlled Trial of Metronidazole 1% Cream with Sunscreen SPF 15 in Treatment of Rosacea

Abstract: The combined topical formulation of metronidazole 1% cream with sunscreen SPF 15 was an effective, well-tolerated topical agent for the treatment of moderate to severe rosacea.

Cited by 21 publications

References 5 publications

Rosacea and its management: an overview

Rosacea and its management: an overview

Evaluating the Quality of Rosacea Studies: Implications for the Patient and Physician

Guías clínicas para el tratamiento de la rosácea

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