2015
DOI: 10.1007/s11695-015-1858-5
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Randomized, Prospective Comparison of Ursodeoxycholic Acid for the Prevention of Gallstones after Sleeve Gastrectomy

Abstract: The incidence of gallstones is higher than previously estimated in SG patients. UDCA significantly lowers the gallstone formation rate at 6 months postoperatively.

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Cited by 69 publications
(33 citation statements)
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“…More conservative options include treatment with ursodeoxycholic acid, a bile acid that reduces cholesterol and mucin concentrations, within the first 6 months after surgery [10,[22][23][24]27]. Analysis of different dosages has suggested that 300-600 mg/day significantly reduces gallstone formation and can be used in patients after bariatric surgery without associated cholecystectomy (grade A) [26].…”
Section: Discussionmentioning
confidence: 99%
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“…More conservative options include treatment with ursodeoxycholic acid, a bile acid that reduces cholesterol and mucin concentrations, within the first 6 months after surgery [10,[22][23][24]27]. Analysis of different dosages has suggested that 300-600 mg/day significantly reduces gallstone formation and can be used in patients after bariatric surgery without associated cholecystectomy (grade A) [26].…”
Section: Discussionmentioning
confidence: 99%
“…A recent meta-analysis of 5 randomized controlled trials involving 521 patients found that the rate of gallbladder disease/ gallstone formation was significantly lower in patients receiving postoperative ursodiol (8.8 vs. 27.7 %; p = 0.01). Most of the benefits of such management have been observed within the first 6 months; longer follow-up found no difference in the incidence of de novo gallbladder disease [23]. Because of the heterogeneity of available studies, it has not been clearly established whether this treatment affected the rates of symptomatic disease and emergency cholecystectomy [22].…”
Section: Discussionmentioning
confidence: 99%
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“…Although not included in these data, we trialed the administration of ursodiol at the time of LSG to prevent postoperative biliary complications. Prior studies in the adult population have supported its use for this indication . However, after initiation of ursodiol therapy two patients returned in the early postoperative period with pancreatitis, and therefore we abandoned this strategy.…”
Section: Discussionmentioning
confidence: 99%
“…3 Multiple approaches have been proposed and studied to prevent gall-stones after weight loss surgery including concomitant cholecystectomy and prophylactic ursodeoxycholic acid (UDCA) treatment following surgery. 4 The aim of this study is to define effectiveness of the using of the ursodeoxycholic acid in reducing incidence of gallstone formation after sleeve gastrectomy operation.…”
Section: Introductionmentioning
confidence: 99%