Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer

Geara, Fady; Eid, Toufic; Zouain, Nicolas; Thebian, Ranim; Andraos, T.Y.; Chehab, C; Ramia, Paul; Youssef, Bassem; Zeidan, Youssef H.

doi:10.1097/coc.0000000000000460

Cited by 22 publications

(14 citation statements)

References 22 publications

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“…Patients may experience a variety of symptoms and signs such as pruritus, erythema, edema, desquamation, necrosis, ulceration, and/or hemorrhage. 1 The mechanisms involved are vascular injury, followed by leukocyte infiltration, and skin barrier breakdown. Leukocyte infiltration is frequently observed in irradiated skin and plays a significant role in tissue damage.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy

Koukourakis

Pissakas

Ganos

et al. 2020

The International Journal of Lower Extremity Wounds

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The aim of this study is to investigate the preventive role of 3 herbal formulation products on reducing the incidence of radiation-induced dermatitis in patients undergoing radiotherapy for either breast or head and neck cancer. A total of 59 patients participated in the study. The novel herbal products, a combination of beeswax, olive oil, Calendula and Hypericum oils and Aloe gel, were daily and regularly being used by the patients during radiotherapy and 2 weeks after treatment end. Acute skin toxicity was scored weekly during radiotherapy and after treatment for a further 4-week follow-up period. Demographic data were analyzed by descriptive statistics. Statistical analyses of the study objectives were based on an intent-to-treat principle. Most of the patients presented with grade I (RTOG/EORTC) toxicity in the first weeks of radiotherapy, progressed to grade II but reverted to grade I toxicity up until the study end. A total of 94.9% of the patients had Dermatology Life Quality Index up to 1, and 66.1% remained in this scale. The application of the novel natural product combinations proved to be statistically significantly effective in reducing the intensity of radiation dermatitis, positively affecting the quality of life of the patients.

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Section: Introductionmentioning

confidence: 99%

Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy

Koukourakis

Pissakas

Ganos

et al. 2020

The International Journal of Lower Extremity Wounds

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“…Although we limited the maximum dose of inguinal and vulvar skin to 50 Gy during IMRT, 35.4% of patients experienced grade 2 acute RID and 18.8% grade 3 acute RID. It has been established that the severity of acute RID directly influences quality of life and interrupts the consistency of radiotherapy, which ultimately negatively affects the expected therapeutic benefit ( 14 , 15 ).…”

Section: Discussionmentioning

confidence: 99%

“…Use of prophylactic triethanolamine emulsion was reported to help reduce acute RID during radiotherapy in previous research; however, most of the targeted cancers were restricted to HNC and breast cancer ( 12 , 22 ). For gynaecological malignancies, few studies have focused on the efficacy of triethanolamine emulsion during IMRT, although in breast cancer, one study reported no significant advantage(s) of triethanolamine over other management strategies ( 15 ). However, Abbas et al confirmed the superiority of triethanolamine emulsion in reducing the severity of acute dermatitis in HNC ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity- modulated radiation therapy

Fu¹,

Wang²,

Chen³

et al. 2020

Transl Cancer Res TCR

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Background: This study aimed to investigate the incidence of and potential risk factors for acute radiationinduced dermatitis (RID) in patients with gynaecological malignancies who underwent intensity-modulated radiation therapy (IMRT).Methods: Ninety-six patients, who were diagnosed with gynaecological malignancies and underwent IMRT in the lower vagina and/or groin at Zhejiang Cancer Hospital (Hangzhou, Zhejiang, China) between January 2012 and June 2014, were enrolled. Clinical data were retrospectively collected. Acute RID grade ≥2 severity was defined as clinically relevant acute RID and sub-grouped accordingly. Univariate and multivariate analyses were performed.Results: The incidence of grades 0, 1, 2, 3, and 4 acute RID was 2.1%, 43.8%, 35.4%, 18.8%, and 0%, respectively. Univariate analysis revealed that clinically relevant acute RID was independently correlated with hyperglycaemia (defined as venous fasting blood glucose level ≥7.1 mmol/L for 2 consecutive measurements), concurrent chemotherapy, and prophylactic use of triethanolamine emulsion (P<0.05). Patient age (P=0.521), body mass index (BMI) (P=0.893), and radiation boost (P=0.870) were not statistically significant factors.All variables with P<0.1 were included in the multivariate analysis together with radiation boost. Similarly, clinically relevant acute RID was independently correlated with hyperglycaemia [odds ratio (OR) 3.150; 95% confidence interval (CI), 1.019-9.736; P=0.046], synchronous chemotherapy (OR 3.515; 95% CI, 1.362-9.072; P=0.009), and prophylactic use of triethanolamine emulsion (OR 0.412; 95% CI, 0.170-0.998; P=0.049).Conclusions: Hyperglycaemia and synchronous chemotherapy were independent predictive factors for clinically relevant acute RID. Prophylactic use of triethanolamine emulsion may help to reduce the incidence of clinically relevant acute RID.

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“…8 Silver nylon dressing is superior to SSD in lowering mean RD score, 9 and superior to standard care with steroids, moisturizers, and SSD to decrease pruritus, pain, and burning. 10 Herbal remedies including calendula 11 and β-sitosterol 12 may help treat RD. Multiple randomized studies do not support use of aloe vera, 13 and have shown mixed results for hyaluronic acid, trolamine, and sucralfate.…”

Section: S2 Of S12mentioning

confidence: 99%

Supportive care for toxicities in children undergoing radiation therapy

Patel

Vargo

Olson

et al. 2021

Pediatric Blood & Cancer

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Radiation therapy (RT) is an integral part of the management of many pediatric tumors; however, it is associated with both acute and permanent adverse events that can significantly impact a child's quality of life, lead to treatment delays, and potentially affect outcomes of cancer therapy. Prevention, early detection, and optimal management of these adverse effects will help reduce their impact on the patients’ quality of life and overall well‐being. Unfortunately, there has not been a coordinated effort to study the etiology, evaluate risk factors, and explore novel treatments for these conditions. Studies of supportive care for children undergoing RT are often small and uncontrolled. This review will focus on the impact of irradiation on the different organ systems and their current management. Further studies are required to improve our understanding of the contributing factors and explore novel treatment options for these adverse effects and to enable children and their families to better cope with some of the unavoidable toxicities following multimodality therapy.

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Randomized, Prospective, Open-label Phase III Trial Comparing Mebo Ointment With Biafine Cream for the Management of Acute Dermatitis During Radiotherapy for Breast Cancer

Cited by 22 publications

References 22 publications

Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy

Effectiveness and Tolerability of Natural Herbal Formulations in the Prevention of Radiation-Induced Skin Toxicity in Patients Undergoing Radiotherapy

The incidence and risk factors of acute radiation-induced dermatitis in gynecologic malignancies treated with intensity- modulated radiation therapy

Supportive care for toxicities in children undergoing radiation therapy

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