Randomized Split-Mouth Study for Evaluating the Efficacy of Nimesulide and Nimesulide + Thiocolchicoside Combination Following Impacted Mandibular Third Molar Surgery

Kasapoğlu, Metin Berk; Cebi, A T

doi:10.4103/njcp.njcp_1623_21

Cited by 4 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Применение нимесулида, в т. ч. и упреждаю щее/превентивное, продемонстрировало эффективный послеоперационный контроль боли при операциях на пародонте, манипуляциях на периодонте, одонтогенных воспалительных заболеваниях, хирургических вмешательствах на третьих молярах [112,116,117,119,122,123,[125][126][127][128][129][130]. После хирургического удаления третьих моляров нимесулид эффективно контролирует боль, отек и тонический спазм жевательной мускулатуры (тризм) [117,122,125,127].…”

Section: нимесулид в лечении лицевой и орофациальной болиunclassified

Orofacial and facial pain during the new coronavirus infection (COVID-19) pandemic. Choosing a non-steroid anti-inflammator – focus on nimesulide

et al. 2022

View full text Add to dashboard Cite

Doctors of various specialties face orofacial and facial pain in their practice: dentists, maxillofacial surgeons, neurologists, neurosurgeons, otorhinolaryngologists, therapists, general practitioners, traumatologists, ophthalmologists, psychotherapists, physiotherapists, aesthetic medicine doctors, anesthesiologists, plastic surgeons and other specialists. The novel coronavirus infection (COVID-19) pandemic, spread by the SARS-CoV-2 virus, has become a challenge for all medical specialties and health care systems around the world. The respiratory system is the dominant target of SARS-CoV-2. The oral mucosa is also highly susceptible to SARS-CoV-2 infection, due to the wide distribution of angiotensin-converting enzyme type II receptors in the oral cavity. We searched the literature for the period from the beginning of the pandemic until August 22, 2022, on the study of the association of orofacial pain with a new coronavirus infection COVID-19 in the electronic search engines PubMed and Scopus. Analysis of the found sources indicates an increase in the frequency of various types of orofacial pain associated with 1) violation of dentoalveolar and related structures during the COVID-19 pandemic; 2) temporomandibular disorders; 3) with damage or disease of the cranial nerves; and 4) like manifestations of primary headache. This growth is due both directly to the infection caused by SARS-CoV-2, its complications, and to a complex of biopsychosocial factors directly related to the pandemic. In the second part of the article, as part of the review, the possibility of using nimesulide for the treatment of orofacial and facial pain during the COVID-19 pandemic is discussed. The choice of nimesulide is supported by 1) the likely coadjuvant effect of nimesulide in the treatment of COVID-19; 2) positive experience with the use of nimesulide in the treatment of facial and orofacial pain in the period preceding the COVID-19 pandemic; 3) the safety of using nimesulide in comorbid patients, who are the main risk group for the development and severe course of COVID-19.

show abstract

Section: нимесулид в лечении лицевой и орофациальной болиunclassified

Orofacial and facial pain during the new coronavirus infection (COVID-19) pandemic. Choosing a non-steroid anti-inflammator – focus on nimesulide

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Various strategies and interventions have been proposed to manage the immediate inflammatory response associated with third molar removal surgery. These include analgesics, antibiotics, corticosteroids, surgical drains, various flap and wound closure designs, and adjunctive measures such as the use of laser therapy, cryotherapy, ozone gel, platelet-rich plasma, and platelet-rich fibrin [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effect of Primary and Secondary Closure on the Use of Leukocyte and Platelet-Rich Fibrin in Impacted Lower Third Molar Surgery

Orhan,

Ciğerim,

Güzel

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

The aim of this study was to compare the effect of using L-PRF in patients undergoing impacted lower third molar surgery with either primary or secondary closure techniques. Methods: This prospective, randomized, double-blind, split-mouth clinical trial was conducted on patients with bilateral impacted lower third molars of a similar position. Primary closure was performed in group 1 and secondary closure in group 2. The group 1 closure technique was applied to one side of the patients, and the group 2 closure technique was applied to the other side at different times. Of the 45 patients evaluated, 9 patients were excluded from the study because of alveolitis and failure to attend regular control visits out. Results: Of the 36 patients included in the study, 23 were female and 13 were male, with a mean age of 22.42 ± 3.36 years. The secondary closure group had lower VAS scores at hour 6 (p < 0.05). Pain decreased more in the primary closure group when comparing changes between the VAS scores at 6 hours and 7 days (p < 0.05). Conclusions: The results of this study, showing that both secondary and primary closure are effective, with similar outcomes in terms of pain, swelling, and trismus, should be supported by future clinical trials.

show abstract

Possibilities of using nimesulide in clinical practice, features of use in dorsopathy

Yakovlev

Gnevyshev²,

Ачкасов

et al. 2023

Medicinskij sovet

View full text Add to dashboard Cite

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a structurally diverse group of drugs with a common mechanism of action (reversible inhibition of cyclooxygenase). They are widely used due to their analgesic, antipyretic and anti-inflammatory properties; available both as prescription and over-the-counter medications; available as individual pharmaceuticals, compound painkillers. The methods of treatment of acute and chronic pain are different. For acute pain, analgesics such as nonsteroidal anti-inflammatory drugs and opiates are commonly used, sometimes in combination with regional anesthesia such as peripheral nerve blockade or peridural local anesthesia. A systematic review and meta-analysis of the efficacy and safety of nimesulide published in the sources MEDLINE/PubMed, Embase, Cochrane Library and China National Knowledge Infrastructure. The efficacy and safety of the use of nimesulide in clinical practice is shown. In particular, in the treatment of acute musculoskeletal pain (dorsopathy of the cervical-thoracic and lumbar region), as well as migraines, due to a decrease in the release of calcitonin- gene related peptide (CGRP) and prostaglandin E2 (PGE2) from the trigeminal ganglia, while other NSAIDs have shown a lack of efficacy. Noncompliance with international guidelines, irrational use of NSAIDs among all groups of drugs is one of the leading causes of hospitalizations associated with side effects, which increases health care costs. The article presents an overview of the safety and efficacy of medicines containing nimesulide, as well as recommendations for patients and prescribers of this drug.

show abstract

Randomized Split-Mouth Study for Evaluating the Efficacy of Nimesulide and Nimesulide + Thiocolchicoside Combination Following Impacted Mandibular Third Molar Surgery

Cited by 4 publications

References 19 publications

Orofacial and facial pain during the new coronavirus infection (COVID-19) pandemic. Choosing a non-steroid anti-inflammator – focus on nimesulide

Orofacial and facial pain during the new coronavirus infection (COVID-19) pandemic. Choosing a non-steroid anti-inflammator – focus on nimesulide

Evaluation of the Effect of Primary and Secondary Closure on the Use of Leukocyte and Platelet-Rich Fibrin in Impacted Lower Third Molar Surgery

Possibilities of using nimesulide in clinical practice, features of use in dorsopathy

Contact Info

Product

Resources

About