Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients

Motoori, Masaaki; Yano, Masahiko; Miyata, Hiroshi; Sugimura, Keijiro; Saito, Takuro; Omori, Takeshi; Fujiwara, Yoshiyuki; Miyoshi, Norikatsu; Akita, Hirofumi; Gotoh, Kunihito; Takahashi, Hidenori; Kobayashi, Shogo; Noura, Shingo; Ohue, Masayuki; Asahara, Takashi; Nomoto, Koji; Ishikawa, Osamu; Sakon, Masato

doi:10.1016/j.clnu.2015.11.008

Cited by 90 publications

(70 citation statements)

References 28 publications

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“…Diamine oxidase metabolizes polyamines and histamine and is abundant in the small intestine and kidney (Wollin, Wang, & Tso, ). Diamine oxidase activity has been used as a marker of intestinal mucosal integrity in intestinal diseases and after chemotherapy (Motoori et al, ). Previous studies showed that dietary arginine increased significantly arginase activities of yellow catfish, rainbow trout and turbot (Fournier et al, ; Zhou et al, ).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

et al. 2019

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The effects of N‐carbamylglutamate (NCG) on growth, intestinal enzyme activities, immunological and antioxidant parameters were evaluated by a 56‐d feeding trial in Pelteobagrus fulvidraco fed diets containing NCG with 0, 250, 500, 1,000 or 2,000 mg/kg, respectively. The results showed that 250 mg/kg of NCG resulted in significantly higher weight gain, intestine fold height, intestine lipase, serum lysozyme, glutathione peroxidase and total antioxidant capacity than control (p < 0.05). However, higher intestine trypsin, arginase, arginine decarboxylase, ornithine decarboxylase, diamine oxidase activities and serum nitric oxide content were observed in 500 mg/kg NCG group compared to control or 2,000 mg/kg (p < 0.05). The survival rate, intestine muscular layer thickness, serum lysozyme and superoxide dismutase activities in 2,000 mg/kg NCG group were significantly lower than those in control and 250 mg/kg group, accompanied by the higher feed conversion ratio in the same group (p < 0.05). Together, dietary NCG level at 250 or 500 mg/kg improved growth, intestinal enzyme activities, immunological and antioxidant abilities, while high NCG level of 2,000 mg/kg had a negative effect. Quadratic regression analysis on weigh growth, diamine oxidase and lysozyme activities indicated that the recommended optimum dietary NCG level was 213.48–314.50 mg/kg of the dry diet.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

et al. 2019

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“…We previously reported that enteral nutrition support during NACT significantly reduced neutropenia and slightly reduced severe diarrhea in patients with esophageal cancer [24]. Furthermore, we recently reported that synbiotics during NACT significantly reduced severe diarrhea and febrile neutropenia [25]. Another approach to maintain skeletal muscle is physical exercise therapy.…”

Section: Discussionmentioning

confidence: 99%

Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer

et al. 2018

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Objective: Neoadjuvant therapy followed by surgery has been the standard treatment for advanced esophageal cancer. Severe toxicities may influence body composition, including skeletal muscle mass, and increase postoperative complications. The purpose of this study was to evaluate the influence of sarcopenia, changes in body composition, and adverse events during neoadjuvant chemotherapy (NACT) on postoperative complications in esophageal cancer patients. Methods: A total of 83 patients with esophageal cancer undergoing NACT followed by esophagectomy were included. Body composition was assessed before chemotherapy and before esophagectomy. The relationships between postoperative infectious complications and sarcopenia, changes in body composition, and adverse events during NACT were investigated. Results: Univariate analysis revealed that skeletal muscle loss during NACT, but not preoperative sarcopenia, was significantly higher in the complication (+) group. Febrile neutropenia tended to occur frequently in the complication (+) group. Multivariate analysis demonstrated that skeletal muscle loss was the only factor significantly associated with infectious complications (p = 0.029). Among adverse events, febrile neutropenia was significantly associated with a decrease in skeletal muscle mass. Conclusion: Loss of skeletal muscle mass during NACT was a significant risk factor for postoperative infectious complications in patients with esophageal cancer. Prevention of severe adverse events may reduce postoperative infectious complications.

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“…Severe lymphopenia and diarrhea were less frequent in patients who received synbiotics than in the control group. Furthermore, febrile neutropenia occurred less in the synbiotics group compared to the control group [107]. Chemotherapy may disturb the intestinal microbiota, leading to reduced production of organic acids in the bowel, impaired mucosal integrity, and increased harmful bacteria.…”

Section: Nutritional Interventions During Chemoradiotherapymentioning

confidence: 99%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

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Esophageal cancer is associated with malnutrition in the vast majority of patients. This phenomenon is partly attributed to the disease process itself, the location of the tumor and other factors, such as dysphagia which is often accentuated due to chemotherapy/ radiotherapy treatment or surgical intervention. The poor nutritional status of these patients is often related to the presence of cancer cachexia, altered metabolism, and tissue wasting. Malnutrition in this patient population affects quality of life, worsens patient's tolerance to chemotherapy and accounts for lower survival. Nutritional management of these patients includes both proper nutritional assessment and support and might prevent, to a certain extent, the manifestation of malnutrition-related consequences. The purpose of this article is to review the current literature in order to focus on the etiology and diagnosis of malnutrition in esophageal cancer patients, emphasizing also on the optimal nutritional support during multimodality treatment.

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Randomized study of the effect of synbiotics during neoadjuvant chemotherapy on adverse events in esophageal cancer patients

Cited by 90 publications

References 28 publications

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

Dietary supplementation of N‐carbamylglutamate and effects on growth, intestinal enzyme activities, immunological and antioxidant abilities of juvenile yellow catfish (Pelteobagrus fulvidraco)

Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer

Nutritional Management of Esophageal Cancer Patients

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