Randomized study to compare the effect of pregabalin with fixed-drug combination of pregabalin and methylcobalamin in the patients of postherpetic neuralgia

Jha, Asmita; Siddalingappa, Karjigi; Herakal, Kallappa; Malhotra, Karan

doi:10.4103/ijpn.ijpn_10_18

Cited by 4 publications

(5 citation statements)

References 2 publications

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“…In the present study, the efficacy and safety of pregabalin and nortriptyline were compared in patients of PHN. All patients were in higher age group with most common involvement of thoracic dermatome (64.58%), which was similar to earlier reports [7,13]. Herpes zoster virus located in the dorsal root ganglion gets reactivated in old age leading to the degeneration of the spinal nerve sensory system and increased neuropathic pain [14].…”

Section: Discussionsupporting

confidence: 88%

Comparison of Pregabalin and Nortriptyline on Efficacy and Safety in Postherpetic Neuralgia

Khajuria

Gupta

Dogra

et al. 2021

Asian J Pharm Clin Res

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Objectives: Antidepressants and anticonvulsants are most commonly prescribed in postherpetic neuralgia (PHN). The aim of the present study was to compare the efficacy and safety of pregabalin and nortriptyline in patients of PHN. Methods: The present study was conducted in 48 patients of PHN attending outpatient department of Dermatology, GMC Jammu. After obtaining written consent, the enrolled patients were randomized into two groups, one group was given pregabalin 150 mg orally per day, and other group was treated with nortriptyline 25 mg orally per day and were followed up to 8 weeks. Patients were assessed on numerical rating scale (NRS), Leeds assessment of neuropathic symptoms and signs (LANSS). Safety of the drugs was monitored by adverse drug reactions (ADRs). Results: All patients were over 57 years and thoracic dermatome was most affected. Both drugs significantly reduced NRS and LANSS (p<0.0001). However, on comparison pregabalin was found to be better than nortriptyline at 8 weeks on mean NRS (p= 0.0073), LANSS (p=0.0032). Total of six mild ADRs occurred, two in group pregabalin and four in nortriptyline treated group. Conclusion: Both pregabalin and nortriptyline were effective in patients of PHN, but pregabalin was found to be better than nortriptyline at 8 weeks. Both drugs were well tolerated, though pregabalin had lesser number of ADRs.

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Section: Discussionsupporting

confidence: 88%

Comparison of Pregabalin and Nortriptyline on Efficacy and Safety in Postherpetic Neuralgia

Khajuria

Gupta

Dogra

et al. 2021

Asian J Pharm Clin Res

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“…21 Pregabalin is selected as the first-line drugs for the therapy of neuropathic pain, persistent numbness. 6,11 Pregabalin is an antagonist of voltage gated Ca2+ channels and capable to regulate different potassium channels.…”

Section: Discussionmentioning

confidence: 99%

“…22 Mecobalamin is a crucial constituent in the synthesis of the myelin sheath, the recovery and protection of nerve function. 6,11 Mecobalamin is a synthetic and active form of vitamin B12 and acts as an important cofactor in activities of B( 12)-dependent methyltransferases.…”

Section: Discussionmentioning

confidence: 99%

“…Methylcobalamin has a crucial function in the of myelin sheath and aids to recover the function of the nerve in neuropathy. 4,11 The objective of the present case reports was to carry out treatment of inferior alveolar nerve and facial nerve neuropathy of the FDC of sustained-release pregabalin and immediate release methylcobalamin (PGM-SR) in healing neuropathic pain in daily practice.…”

Section: Introductionmentioning

confidence: 99%

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Fixed Dose Combination of Mecobalamin and Pregabalin in the Treatment of Orofacial Neuropathic Pain

Lugito

2024

interdental

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Introduction: orofacial neuropathic pain is extraordinary disease in character with its complicated management. Mecobalamin has been used to provide regeneration of traumatized nerves. Pregabalin with its analgesic activities relieves the clinical signs of neuropathic pain. The aim of this case report is to explain fixed dose combination of Mecobalamin and Pregabalin as the treatment of neuropathic pain caused by inferior alveolar nerve and facial nerve neuropathy. Case: First case was an inferior alveolar nerve neuropathy experienced by 63 years old female with complaints of persistent pain and numbness around the left chin and left lower lip the day following the procedure of surgery for the treatment of dentoalveolar abscess on left second premolar of mandibula. Second case was facial nerve neuropathy experienced by 54 years old female had persistent pain and numbness of the anterior two-thirds of the tongue after total thyroidectomy and 1,100 MBq (30 mCi) activity of Radioactive iodine (RAI) therapy, followed with two 131I whole body scans. Case Management: Mecobalamin 500 µg and Pregabalin 75 mg twice daily for 5 weeks were given with tolerable side effects and improvement symptoms. Discussion: Pregabalin combined with Mecobalamin can reduce orofacial neuropathic pain. Pregabalin possess analgesic property and reduce neuropathy-related pain symptoms while Mecobalamin facilitates myelinogenesis and nerve regeneration. Conclusion: Fixed Dose Combination of Mecobalamin and Pregabalin has the potential analgesic effect, reduced neuropathic orofacial pain at a below than determined dosage in case of inferior alveolar and facial nerve neuropathic pain.

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“…Depending upon the duration of neuralgia from onset of rash, herpetic neuralgia is divided into three types, acute (within a month), subacute (1-3 months) and post herpetic neuralgia (beyond three months). [1][2][3] Treatment modalities used for herpetic neuralgia includes medical (systemic tricyclic antidepressants, anticonvulsants and opioids), topical (Lidocaine, Tramadol and Capsaicin), interventional (local injections, nerve blocks and nerve stimulation) therapies and conventional (Acupoint injection). 4,5 Methycobalamin has an important role in myelin sheath synthesis and integrity.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Local Methylcobalamine Injection Versus Local Bupivacaine Injection for the Treatment of Acute Herpetic Neuralgia

Yasmin

Raza

Bari

et al. 2022

PAFMJ

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Objective: To compare the reduction in mean pain score with local Methylcobalamin injection versus local Bupivacaine injection in patients with acute herpetic neuralgia. Study Design: Quasi experimental study. Place and Duration of Study: Dermatology Outpatient Department, Pak Emirates Military Hospital, Rawalpindi, from Jun to Dec 2019. Methodology: Total 100 patients, having pain score more than 3, fulfilling the selection criteria were divided into two groups. Group A was treated with daily subcutaneous injection Bupivacaine, whereas Group B was treated with daily subcutaneous injection Methycobalamin at the site of neuralgia. Patients were followed up for 4 weeks. The pain score was noted. All the data was entered and analyzed on SPSS version 21. Results: In this study mean age of patients in group A was 43.82 ± 15.76 years and in group B was 44.76 ± 16.92 years. The mean visual analogue pain score at 4th week in the group A patients was 1.14 ± 0.32 and in group B was 1.90 ± 0.97. Statistically significant difference was found in group A (local Bupivacaine) with visual analogue score (VAS) at 4th week (pvalue=0.002). Conclusion: The local Bupivacaine injection showed significant reduction in mean pain score than local Methylcobalamin injection in patients with acute herpetic neuralgia.

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Randomized study to compare the effect of pregabalin with fixed-drug combination of pregabalin and methylcobalamin in the patients of postherpetic neuralgia

Cited by 4 publications

References 2 publications

Comparison of Pregabalin and Nortriptyline on Efficacy and Safety in Postherpetic Neuralgia

Comparison of Pregabalin and Nortriptyline on Efficacy and Safety in Postherpetic Neuralgia

Fixed Dose Combination of Mecobalamin and Pregabalin in the Treatment of Orofacial Neuropathic Pain

Comparison of Local Methylcobalamine Injection Versus Local Bupivacaine Injection for the Treatment of Acute Herpetic Neuralgia

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