Randomized trial of aromatherapy versus conventional care for breast cancer patients during perioperative periods

Tamaki, Kentaro; Fukuyama, Akiko; Terukina, S; Kamada, Yoshihiko; Uehara, Kanou; Arakaki, M; K, Yamashiro; Miyashita, Minoru; Ishida, Toru; McNamara, Keely May; Ohuchi, Noriaki; Tamaki, Nobuharu; Sasano, Hironobu

doi:10.1007/s10549-017-4134-7

Cited by 28 publications

(33 citation statements)

References 17 publications

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“…e results showed no efficacy of aromatherapy in improving the quality of life, vital signs, and sleep quality. According to the Tamaki et al, insufficient sample size can be one of the reasons for finding no subtle changes in the quality of life, vital signs, and sleep quality of breast cancer patients [37]. Our results are not consistent with those of Tamaki et al, due to the use of different types of aromas and the short duration of intervention in the study by Tamaki et al In the present study, one type of aroma was used for each intervention group and the duration of the intervention was one week.…”

Section: Discussionmentioning

confidence: 99%

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Hamzeh

Safari‐Faramani

Khatony

2020

Evidence-Based Complementary and Alternative Medicine

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One of the problems of cancer patients is sleep disorder. Given the absence of studies on comparing the effect of inhalation aromatherapy with lavender and peppermint on the sleep quality of the cancer patients, this study was performed to compare the effect of inhalation aromatherapy with lavender and peppermint essential oils on the sleep quality of cancer patients. For this purpose, 120 patients were randomly allocated to three groups of lavender, peppermint, and control. The intervention groups received three drops of the essential oil for 7 days. In the control group, aromatic distilled water was used instead. Pittsburgh Sleep Quality Inventory (PSQI) was used. Before the intervention, no significant difference was observed between the mean PSQI scores of three groups, while the difference was statistically significant after the intervention. The mean PSQI scores were lower in lavender and peppermint groups than in the control group. Aromatherapy can improve the sleep quality of cancer patients. To confirm the findings, more studies should be done.

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Section: Discussionmentioning

confidence: 99%

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Hamzeh

Safari‐Faramani

Khatony

2020

Evidence-Based Complementary and Alternative Medicine

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“…Due to their minimal cytotoxicity 13 , 14 , EOs are considered pharmaceutically safe and could represent a good alternative natural source of anticancer agents, thus deserving further investigations to ascertain their mechanism of action and to validate their possible clinical uses as alternative/complementary antitumor agents. In the last 20 years, preclinical studies demonstrated anticancer activity of either some EOs or their main components 15 , 16 and led to case–control studies 17 and clinical trials 18 – 20 .…”

Section: Introductionmentioning

confidence: 99%

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

et al. 2021

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Essential oils (EOs) have been recently emerging for their promising biological activities in preventing tumorigenesis or progression of different tumor histotypes, including melanoma. In this study, we investigated the antitumor activity of a panel of EOs in different tumor models. The ability of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol, to sensitize the target therapy currently used for melanoma treatment was also assessed. Our results demonstrated that EOs differently affect the viability of human cancer cells and led us to select six EOs effective in melanoma and lung cancer cells, without toxic effects in human fibroblasts. When combined with dabrafenib and/or trametinib, Melaleuca alternifolia synergistically reduced the viability of melanoma cells by activating apoptosis. Through machine learning classification modeling, α-terpineol, tepinolene, and terpinen-4-ol, three components of Melaleuca alternifolia, were identified as the most likely relevant components responsible for the EO’s antitumor effect. Among them, terpinen-4-ol was recognized as the Melaleuca alternifolia component responsible for its antitumor and proapoptotic activity. Overall, our study holds promise for further analysis of EOs as new anticancer agents and supports the rationale for their use to improve target therapy response in melanoma.

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“…In this regard, while non-toxic, non-invasive and well received and tolerated, the inhaled Zingiber officinale EO was not an effective complementary therapy for chemotherapy-induced nausea and vomiting and health-related quality of life neither in children with cancer [258] nor in women with breast cancer [259]. While not showing any harm or adverse events, the study by Sasano's group evidenced no effects of aromatherapy on quality of life, sleep quality, and vital sign during perioperative periods of breast cancer patients [260]. Meta-analysis of three randomized controlled trials including a total of 278 participants did not show any clinical effect of aromatherapy massage on reducing pain in cancer patients [261].…”

Section: Clinical Use Of Eos For Cancer Patientsmentioning

confidence: 90%

“…Pharmacokinetic studies are needed to validate the safety and efficacy of EOs and their bioactive compounds. In fact, even if several papers indicated EOs and their components as safe and not toxic [258][259][260], hepatotoxicity described for monoterpenes and sesquiterpenes, major components of many EOs, should be also considered and should deserve more attention [264]. Further studies on terpene metabolism and toxicity need to be performed to avoid the risk of eventual liver injury.…”

Section: Discussionmentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Randomized trial of aromatherapy versus conventional care for breast cancer patients during perioperative periods

Cited by 28 publications

References 17 publications

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Antitumor effect of Melaleuca alternifolia essential oil and its main component terpinen-4-ol in combination with target therapy in melanoma models

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

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