“…We found 70 RCTs examining NRT versus control interventions (See Figure 1 and Additional File 1), [30-99] 49 of which compared NRT to placebo [30,32,34,35,38,39,43,44,46,48,50,54,56-59,62,64-69,71-82,84-87,89-91,93,94,96,98,99] thirty one studies compared NRT to other controlled groups (See table 1) [31,33,36,37,40-42,45,49,51-53,55,61,63,70,83,88,92,95,97] and 1 study uses both placebo and no intervention as control group[47]. …”