Randomized trial of drip infusion versus bolus injection of vinorelbine for the control of local venous toxicity

Yoh, Kiyotaka; Niho, Seiji; Goto, Kōichi; Ohmatsu, Hironobu; Kubota, Keiichi; Kakinuma, Ryutaro; Saijo, Nagahiro; Nishiwaki, Yutaka

doi:10.1016/j.lungcan.2006.10.016

Cited by 31 publications

(22 citation statements)

References 8 publications

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“…The dysfunction of endothelial cell apoptosis has been observed in human diseases and experimental models, including atherosclerosis, ischemia-reperfusion and sepsis (17)(18)(19). VIN is a moderate vesicant that has been known to cause local venous toxicity (3,6). Although the pathogenesis of VIN has been little reported, it has previously been suggested that improper endothelial cell apoptosis could be responsible for the local venous toxicity caused by the VIN (19).…”

Section: Discussionmentioning

confidence: 99%

“…VIN is typically administered through a peripheral vein (2-4); however, the drug is a moderate vesicant and causes local venous toxicity. The incidence of VIN-induced local venous toxicity has been reported to be ~30% (5,6). Although infusion phlebitis is common, its pathogenesis is not fully understood; however, it has been suggested that the pathogenesis is associated with chemical irritation of the endothelial cells, leading to sterile inflammation and thrombosis (7,8).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Qian

Gao

Chen

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. Vinorelbine (VIN) is a semi-synthetic vinca alkaloid and is one of the most active agents for the treatment of solid tumors. The drug is commonly administered through a peripheral vein. Although VIN is known to cause local venous toxicity, such as drug-induced phlebitis, the mechanism responsible for the toxicity remains unclear. To investigate the role of Toll-like receptor 4 (TLR4) in VIN-induced vascular endothelial injury, human umbilical vein endothelial cells (HUVECs) were prepared from umbilical cords recovered with the written informed consent of the parents and treated with VIN for 60 min. Following the washing away of the VIN, the cells were cultured for a further 6 and 12 h, and the changes in TLR4 expression in the HUVECs were detected by quantitative polymerase chain reaction and western blot analyses. Finally, the effects of VIN on the translocation of nuclear factor κB (NF-κB) were determined by immunofluorescence and confocal analysis. The VIN-treated cells were stretched, extended and irregular while the control cells exhibited normal morphology. The TLR4 mRNA and protein levels were significantly higher in the VIN-treated HUVECs than those in the control group (P<0.05). The rate of NF-κB p65 nuclear translocation in the VIN-treated HUVECs was significantly higher than that in the vehicle-treated group (P<0.05). These results indicated that TLR4 is involved in the development of VIN-induced vascular endothelial injury by affecting the translocation of NF-κB.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Qian

Gao

Chen

et al. 2015

Experimental and Therapeutic Medicine

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“…29 Essential oils, such as β-E, are well known to cause venous irritation including phlebitis and local reactions. Thus, a new intravenous (iv) dosage form for β-E is required in order to reduce these severe adverse effects.…”

Section: Venous Irritationmentioning

confidence: 99%

“…A slight vascular injury was observed at the injection site because of venipuncture trauma in all three groups. 29 Two days after the injection, edema and erythema were macroscopically observed at the injection site of the positive control. However, there was no obvious discoloration or damage at, or away from, the injection site in either the β-E-NLC groups or the negative control group.…”

Section: Venous Irritationmentioning

confidence: 99%

Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers

Shi¹,

Yang²,

Ren³

et al. 2013

IJN

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Abstract:In the present study, nanostructured lipid carriers (NLCs) were prepared and optimized for the intravenous delivery of β-Elemene (β-E). Aqueous dispersions of NLCs were successfully prepared by high-pressure homogenization method using glycerol monostearate as the solid lipid and a mixture of Maisine 35-1 and Labrafil M1944 CS as the liquid lipid. The results revealed that the morphology of the NLCs was spheroidal. The particle size, zeta potential, and entrapment efficiency (EE) for the optimized formulation were observed as 138.9 nm, −20.2 mV, and 82.11%, respectively. X-ray diffraction analysis revealed the formation of less ordered structures in the inner core of the NLC particles. Moreover, the β-E-loaded NLCs were also less irritating and less toxic compared to Elemene injection. In addition, β-E-NLCs showed a significantly higher bioavailability and anti-tumor efficacy than Elemene injection. Taken together, our data indicate that the β-E-NLCs described in this study are well-suited for the intravenous delivery of β-E.

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“…One reason for that is the chemotherapy always has multiple courses, and patients need to get long and repeated infusion therapy and the antineoplastic drugs have strong stimulation to vessels [4][5][6] . Another reason is that antineoplastic drugs possess cellular and chemical toxicity 7 . Lastly, the immune system of the patient with tumour is usually compromised and vulnerable to phlebitis 8,9 .…”

Section: Introductionmentioning

confidence: 99%

The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis

et al. 2016

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PURPOSE:To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment. METHODS:Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grades of phlebitis through visual observation and histopathological examination were observed. The second series had also 24 rabbits.Interventions were performed 12 hours after vincristine infusion. These rabbits were randomly divided into four groups, according to treatment: Hirudoid (bid), Xianchen (daily), Xianchen (tid), Xianchen (five times a day). Four days after intervention, the venous injury through visual observation and histopathological examination were evaluated. RESULTS:Series 1: Phlebitis appeared 12 hours after infusion of vincristine through visual observation. There was a significant difference (p<0.05) between 6 hours and 24 hours, 6 hours and 18 hours through visual observation. However, the inflammation happened 6 hours after infusion, the loss of venous endothelial cells demonstrated differences among four groups through histopathological evaluation (p<0.05). There were significant differences (p<0.05) after 4 days among the intervention groups through visual observation, the effects of Xianchen group (five times a day) were better than Xianchen group (tid) (p<0.01). The treatment of edema demonstrated differences among groups through histopathological evaluation (p<0.05), Xianchen (five times a day) better relieved the degree of edema (p<0.05). CONCLUSIONS:The study showed that inflammatory reaction of phlebitis appeared early. Xianchen can treat vincristine induced phlebitis, as well as Hirudoid. It is particularly effective in the treatment of edema, and there is a remarkable dose-response relationship.

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Randomized trial of drip infusion versus bolus injection of vinorelbine for the control of local venous toxicity

Cited by 31 publications

References 8 publications

Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers

The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis

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Randomized trial of drip infusion versus bolus injection of vinorelbine for the control of local venous toxicity

Cited by 31 publications

References 8 publications

Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Involvement of Toll-like receptor 4 in vinorelbine-induced vascular endothelial injury

Formulation design, preparation, and in vitro and in vivo characterizations of &beta;-Elemene- loaded nanostructured lipid carriers

The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis

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Formulation design, preparation, and in vitro and in vivo characterizations of β-Elemene- loaded nanostructured lipid carriers