Randomized trial of mifepristone and buccal or vaginal misoprostol for abortion through 56 days of last menstrual period

Mifepristone With Buccal Misoprostol for Medical Abortion

“…14,22,23 Outcomes by gestational age were reported for 12,050, 4,032, and 2,153 women with pregnancies 49 days or less, 50-56 days, and 57-63 days of gestation, respectively. All studies used 800 micrograms misoprostol buccally 11,[14][15][16][22][23][24][25][26][27][28][29][30] except for one study that reported clinical outcomes with 400 micrograms misoprostol buccally. 31 One study described the actual time interval at which patients administered misoprostol after mifepristone, reporting a median interval of 48 hours (range 25-52 hours) for women who took mifepristone at home and a median interval of 47 hours (range 26-54 hours) for women that took mifepristone in the clinic.…”

“…We used November 2005 as the earliest publication date limit because it is the known time of the first study reporting mifepristone followed by buccal misoprostol. 11 We also searched through …”

Acceptability and Feasibility of Mifepristone-Misoprostol for Menstrual Regulation in Bangladesh

“…Studies on this regimen in other settings have found success rates of 95-98%. [15][16][17] Studies have shown slightly lower success rates when medication abortion is first introduced into existing services because providers with less experience with the procedure may be more likely to intervene surgically rather than practice expectant management when the uterus is not completely emptied. 18 An efficacy rate of 85% would be feasible for implementation in clinics in Bangladesh, as the method would present a viable alternative to the standard vacuum aspiration services currently offered in these settings.…”

A prospective randomized, placebo-controlled trial comparing mifepristone and vaginal misoprostol to vaginal misoprostol alone for elective termination of early pregnancy

“…Majority of women were in 21 -30 years age group. The mean age of patients was 22.3 years in the study by Scaff et al and 26 years in both buccal and vaginal groups in the study by Middleton et al [11,12]. In the present study 54.5% patients were from urban background with remaining 35.5% coming from rural background.…”