Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia

Mellin, Juliann M.; Alagapan, Sankaraleengam; Lustenberger, Caroline; Lugo, Courtney E.; Alexander, Morgan L; Gilmore, John H.; Jarskog, L. Fredrik; Fröhlich, Flavio

doi:10.1016/j.eurpsy.2018.01.004

Cited by 87 publications

(98 citation statements)

References 33 publications

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“…Therefore, tACS might offer similar potential for other disorders. We reference the reader to recent studies investigating tACS effects in such disorders (Ahn et al 2019;Alexander et al 2019;Mellin et al 2018). Furthermore, this study presented first support that tACS could be used to increase the amplitude of the P300 using its respective EROs as targets.…”

Section: Closing Commentsmentioning

confidence: 53%

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings

et al. 2020

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Studies examining event-related potentials (ERP) in patients affected by attention deficit/hyperactivity disorder (ADHD) have found considerable evidence of reduced target P300 amplitude across different perceptual modalities. P300 amplitude has been related to attention-driven context comparison and resource allocation processes. Altered P300 amplitude in ADHD can be reasonably assumed to be related to ADHD typical cognitive performance deficits. Transcranial alternating current stimulation (tACS) can increase the amplitude of endogenous brain oscillations. Because ERP components can be viewed as event-related oscillations (EROs), with P300 translating into the delta (0-4 Hz) and theta (4-8 Hz) frequency range, an increase of delta and theta ERO amplitudes by tACS should result in an increase of P300 amplitudes in ADHD patients. In this pilot study, 18 adult ADHD patients (7 female) performed three consecutive blocks of a visual oddball task while the electroencephalogram (EEG) was recorded. Patients received either 20 min of tACS or sham stimulation at a stimulation intensity of 1 mA. Individual stimulation frequency was determined using a time-frequency decomposition of the P300. Our preliminary results demonstrate a significant increase in P300 amplitude in the stimulation group which was accompanied by a decrease in omission errors pre-to-post tACS. However, studies including larger sample sizes are advised.

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Section: Closing Commentsmentioning

confidence: 53%

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings

et al. 2020

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“…Increasing the reliability of low-intensity tES is one of the major challenges for the brain stimulation community. An understanding of the factors determining successful modulation of outcome measures by tES is crucial as the field is advancing these techniques towards clinical applications [5][6][7] . In the current study, we demonstrated that the variability of tACS aftereffects can be explained by an interplay of factors qualitatively capturing the targeting of the stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Among these techniques, transcranial electrical stimulation (tES) using weak direct (tDCS) or alternating (tACS) currents are of particular interest as they provide safe and tolerable stimulation at low costs and high portability 3,4 . These features render tES approaches promising for a wide range of clinical applications [5][6][7] . While tDCS is thought to exhibit its effect by changing neuronal excitability via alterations of neuron's resting membrane polarization 1, [8][9][10] , tACS is believed to work via the principles of neuronal entrainment 2,11 .…”

Section: Introductionmentioning

confidence: 99%

Integrating electric field modelling and neuroimaging to explain inter-individual variability of tACS effects

Kasten

Duecker

Maack

et al. 2019

Preprint

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Variability of transcranial electrical stimulation (tES) effects is one of the major challenges in the brain stimulation community. Promising candidates to explain this variability are individual anatomy and the resulting differences of electric fields inside the brain. Here, we integrated individual simulations of electric fields during tES with source-localization to predict variability Individual differences in electric fields explain tES variability 2 of transcranial alternating current stimulation (tACS) aftereffects on α-oscillations. Forty participants received 20 minutes of either α-tACS (1 mA) or sham stimulation. Magnetoencephalo-

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“…Fourth, our crossover study design only allowed for one session of active stimulation. TACS may have an additive effect on modulating oscillations if a design with multiple sessions were used (75,76).…”

Section: Discussionmentioning

confidence: 99%

Targeting the Autonomic Nervous System Balance in Patients with Chronic Low Back Pain using Transcranial Alternating Current Stimulation: A Randomized, Crossover, Double-Blind, Placebo-Controlled Pilot Study

Prim

Ahn

Davila

et al. 2019

Preprint

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BackgroundChronic low back pain (CLBP) is characterized by an alteration in pain processing by the central nervous system that may affect autonomic nervous system (ANS) balance. Heart rate variability (HRV) reflects the balance of parasympathetic and sympathetic ANS activation. In particular, respiratory sinus arrhythmia (RSA) solely reflects parasympathetic input and is reduced in CLBP patients. Yet, it remains unknown if non-invasive brain stimulation can alter ANS balance in CLBP patients.ObjectiveTo evaluate if non-invasive brain stimulation modulates the ANS, we analyzed HRV metrics collected in a previously published study of transcranial alternating current stimulation (tACS) for the modulation of CLBP through enhancing alpha oscillations. We hypothesized that tACS would increase RSA.MethodsA randomized, crossover, double-blind, sham-controlled pilot study was conducted to investigate the effects of 10Hz-tACS on metrics of ANS balance calculated from electrocardiogram (ECG). ECG data were collected for 2 minutes before and after 40 minutes of 10Hz-tACS or sham stimulation.ResultsThere were no significant changes in RSA or other frequency-domain HRV components from 10Hz-tACS. However, exploratory time-domain HRV analysis revealed a significant increase in the standard deviation of normal RR intervals (SDNN) for 10Hz-tACS relative to sham.Conclusion(s)Although tACS did not significantly increase RSA, we found in an exploratory analysis that tACS modulated an integrated HRV measure of both ANS branches. These findings support the further study of how the ANS and alpha oscillations interact and are modulated by tACS.

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Randomized trial of transcranial alternating current stimulation for treatment of auditory hallucinations in schizophrenia

Abstract: To our knowledge, this is the first clinical trial of tACS for the treatment of symptoms of a psychiatric condition. Further studies with larger sample sizes are needed to better understand the effect of tACS on auditory hallucinations.

Cited by 87 publications

References 33 publications

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings

Transcranial Alternating Current Stimulation (tACS) as a Tool to Modulate P300 Amplitude in Attention Deficit Hyperactivity Disorder (ADHD): Preliminary Findings

Integrating electric field modelling and neuroimaging to explain inter-individual variability of tACS effects

Targeting the Autonomic Nervous System Balance in Patients with Chronic Low Back Pain using Transcranial Alternating Current Stimulation: A Randomized, Crossover, Double-Blind, Placebo-Controlled Pilot Study

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