Randomized trial to compare the effect of a single dose of dexmedetomidine and continuous infusion of remifentanil on airway reflex and hemodynamic response during emergence in patients undergoing cerebral aneurysm clipping

02 / Dexmedetomidine Vs Clonidine to prevent hemodynamic instability during emergence after craniotomy

“…Stability of hemodynamics, absence of hypertension or increased ICP level, secure respiratory function and early neurological assessment are extremely important for neurosurgical patients in the early postoperative period [1]. According several studies alpha-2-adrenergic agonist can be used for hemodynamic stabilization during awakening and extubation [2,3,4,5]. A2adrenominetics can also induce central symphatolysis, anxiolysis and sedation, prolong effect of other anesthetics, prevent hypertensive response on laryngoscopy and tracheal intubation, surgical injury, emergency and extubation [4].…”