Range and demographics of odontogenic cysts diagnosed in a UK population over a 30‐year period

Jones, Aled; Craig, Gavin A.; Franklin, C.D.

doi:10.1111/j.1600-0714.2006.00455.x

Cited by 278 publications

(464 citation statements)

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“…Odontogenic origin has also been confirmed immunohistochemically by several investigators [4][5][6][7][8]. GOC is a rare lesion comprising only 0.2% of all odontogenic cysts [9,10].…”

Section: Introductionmentioning

confidence: 86%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

135

172

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The glandular odontogenic cyst (GOC) is now a relatively well-known entity with recent reviews indicating over 100 cases reported in the English literature. The GOC's importance relates to the fact that it exhibits a propensity for recurrence similar to the odontogenic keratocyst, and that it may be confused microscopically with central mucoepidermoid carcinoma (CMEC). Numerous histopathologic features for the GOC have been described, but the exact microscopic criteria necessary for diagnosis have not been universally accepted. Furthermore, some of the microscopic features of GOC may also be found in dentigerous, botryoid, radicular, and surgical ciliated cysts. The purpose of this multicenter retrospective study is to further define the clinical, radiographic, and microscopic features of GOC, to determine which microscopic features may be helpful for diagnosis in problematic cases, to determine the most appropriate treatment, and to determine if GOC and CMEC share a histopathologic spectrum. In our series of 46 cases, the mean age at diagnosis was 51 years with 71% of cases in the 5th-7th decades. No gender predilection was noted. 80% of cases occurred in the mandible, and 60% of the lesions involved the anterior regions of the jaws. Swelling/expansion was the most common presenting complaint, although some cases were asymptomatic. Radiographically, most cases presented as a well-defined unilocular or multilocular radiolucency involving the periapical area of multiple teeth. Some lesions displayed a scalloped border. Cases also presented in dentigerous, lateral periodontal, and ''globulomaxillary'' relationships. The canine area was a common location for maxillary cases. All cases were treated conservatively (enucleation, curettage, cystectomy, excision). Follow-up on 18 cases revealed a recurrence rate of 50% (9/18), with 6 cases recurring more than once (range of follow-up: 2 months to 20 years; average length of follow-up: 8.75 years). The mean interval from initial treatment to first recurrence was 8 years, and from first recurrence to second recurrence was 5.8 years. Two cases recurred three times and the interval from second to third recurrence was 7 years (exact interval only documented in one case). All cases exhibited eosinophilic cuboidal (hobnail) cells, a feature not specific for GOC, but necessary for diagnosis, in our opinion. Univariate analysis indicated several features that are most helpful in distinguishing GOC from GOC mimickers in problematic cases, including: (1) the presence of microcysts (P \ 0.0001); (2) epithelial spheres 123Head and Neck Pathol (2011) 5:364-375 DOI 10.1007 (P \ 0.0001); (3) clear cells (P = 0.0002); (4) variable thickness of the epithelial cyst lining (P = 0.0002); and (5) multiple compartments (P = 0.006). Stratified analysis indicated that when microcysts are present, epithelial spheres and multiple compartments are still significant, and clear cells are marginally significant in distinguishing GOCs from GOC mimickers. The presence of microcysts (P = 0.00...

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“…Odontogenic origin has also been confirmed immunohistochemically by several investigators [4][5][6][7][8]. GOC is a rare lesion comprising only 0.2% of all odontogenic cysts [9,10].…”

Section: Introductionmentioning

confidence: 86%

Glandular Odontogenic Cyst: Analysis of 46 Cases with Special Emphasis on Microscopic Criteria for Diagnosis

Fowler

Brannon

Kessler

et al. 2011

Head and Neck Pathol

135

172

View full text Add to dashboard Cite

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“…In order to allow a comparison with studies carried out before 2005 [2][3][4][5][6][7][8][9][10], 28 cases of OKC, now KOT, found in our laboratory data were later included in our study and the results were elaborated in the discussion.…”

Section: Methodsmentioning

confidence: 99%

“…Odontogenic cysts account for 7-13% of the lesions diagnosed in the oral cavity [2][3][4][5]. Most of these cysts affect adult men [2][3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Most of these cysts affect adult men [2][3][4][5][6][7][8]. Some studies found that the maxilla was the most frequent anatomic site [3,7,9], whereas other authors reported that the mandible was the most prevalent site [6,8].…”

Section: Introductionmentioning

confidence: 99%

“…Studies about the prevalence of odontogenic cysts have been conducted in several countries and with different ethnic groups [2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Odontogenic Cysts: Analysis of 680 Cases in Brazil

Prockt

Schebela

Maito

et al. 2008

Head and Neck Pathol

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The purpose of this study was to evaluate the prevalence of 680 odontogenic cysts diagnosed in Porto Alegre, RS, Brazil, and to compare results with findings in the literature. Data of odontogenic cysts diagnosed from 1985 to 2005 were collected from the files of the Oral Pathology Laboratory of Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil, and entered in a standardized form for later comparisons. The most prevalent odontogenic cysts were radicular (72.50%), dentigerous (22.20%) and residual (4.26%) cysts. The mandible of white patients was the anatomic site and ethnic group most frequently affected by this disease. Four of the six types of cysts were more frequent in the second and fourth decades of life, and no significant differences were found between sexes in the diagnosis of odontogenic cysts.In conclusion, the prevalence of odontogenic cysts was similar to that reported in the literature, which shows that inflammatory cysts are the most frequent.

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