2023
DOI: 10.20944/preprints202301.0095.v1
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Ranitidine Alleviates Anxiety-Like Behaviour and Improves the Density of Pyramidal Neurons upon Deactivation of Microglia in CA3 Region of the Hippocampus in A Cysteamine Hcl-Induced Mouse Model of Gastrointestinal Disorder

Abstract: Elevated levels of histamine cause the secretion of gastric hydrochloric acid (HCl), leading to gastrointestinal (GI) disorders and anxiety. While aberrant levels of histamine mediate neuroinflammation, pathogenic alterations in the hippocampus of the brain have been linked to anxiety. Eventually, antihistamine drugs that are used against GI disorders appear to be anxiolytic agents. Ranitidine is a widely used antihistamine drug to manage GI disorders as it works by blocking the histamine (H)-2 receptors in ox… Show more

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