Ranitidine Prophylaxis before Anaesthesia in Early Pregnancy

Duffy, Brian L.; Woodhouse, P. C.; Schramm, Mary; Scanlan, C.M

doi:10.1177/0310057x8501300105

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…H 2 -antagonists have been carried out, comparison with the present study is difficult because of varying patient selection, time of administration and anaesthetic regimen, but the results for the omeprazole 1-h group appear to be similar to those obtained with i.v. ranitidine [9][10][11][12]. The reduction in gastric volume at 1 h is not a consistent feature of studies of H 2 -antagonists.…”

Section: Discussionmentioning

confidence: 99%

EFFECT OF I.V. OMEPRAZOLE ON THE pH AND VOLUME OF GASTRIC CONTENTS BEFORE SURGERY

Cruickshank¹,

Morrison²,

Bamber³

et al. 1989

British Journal of Anaesthesia

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Gastric pH and volume were measured in 87 patients who had received i.v. omeprazole (a new gastric antisecretory agent) 40 mg or placebo 1 or 3 h before surgery. Omeprazole increased the pH of gastric contents in the majority of patients. Administration 1 h before surgery produced greater gastric pH and smaller volume than administration 3 h before surgery. There was a reduction in the number of patients with a pH of less than 2.5 and a volume of 25 ml or more in the treated groups compared with the combined placebo groups. Omeprazole may have a role in prophylaxis against acid aspiration syndrome.

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Section: Discussionmentioning

confidence: 99%

EFFECT OF I.V. OMEPRAZOLE ON THE pH AND VOLUME OF GASTRIC CONTENTS BEFORE SURGERY

Cruickshank¹,

Morrison²,

Bamber³

et al. 1989

British Journal of Anaesthesia

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The Effect of Three Different Ranitidine Dosage Regimens on Reducing Gastric Acidity and Volume in Ambulatory Surgical Patients

O'Connor,

Basak,

Parker

1995

Pharmacotherapy

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Study Objective. To evaluate three different preoperative oral dosing regimens of ranitidine in ambulatory patients who had significant risk of aspiration pneumonitis (gastric pH ≤ 2.5 or volume ≥ 25 ml at intubation or extubation).Design. Double‐blind, placebo‐controlled, randomized trial.Setting. St. Francis Hospital of Buffalo, New York.Patients. Two hundred seventy‐one ambulatory patients about to undergo a surgical procedure under general anesthesia, of whom 241 (89%) completed the trial and were considered evaluable.Interventions. Patients were randomly assigned to receive one of four regimens administered orally before surgery: placebo at bedtime the night before and in the morning on the day of surgery; ranitidine 150 mg at bedtime and in the morning; ranitidine 150 mg at bedtime and placebo in the morning; or ranitidine 300 mg at bedtime and placebo in the morning.Measurements and Main Results. Patients who received ranitidine 150 mg twice/day ranitidine 150 mg at bedtime, or ranitidine 300 mg at bedtime had a significantly (p<0.05) lower frequency of a gastric pH 2.5 or below at intubation or extubation than those taking placebo twice/day (3%, 45%, and 31%, respectively, vs 86%). In addition, gastric volume at intubation or extubation was 25 ml or above in significantly fewer patients receiving ranitidine 150 mg at bedtime than placebo (37% vs 13%, p<0.05). Overall, the number of patients with risk factors for aspiration pneumonitis was significantly lower with ranitidine 150 mg twice/day (20%), ranitidine 150 mg at bedtime (48%), and ranitidine 300 mg at bedtime (35%) than placebo (86%) (p<0.001), and significantly lower with ranitidine 150 mg twice/day than ranitidine 150 mg at bedtime (p<0.05).Conclusions. Ranitidine 150 mg twice/day preoperatively reduced to the greatest degree the percentage of patients who developed significant risk factors for aspiration pneumonitis after surgery under general anesthesia.

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Aspiration pneumonitis: Predisposing conditions and prevention

Kinni

Stout

1986

Journal of Oral and Maxillofacial Surgery

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Ranitidine Prophylaxis before Anaesthesia in Early Pregnancy

Cited by 6 publications

References 18 publications

EFFECT OF I.V. OMEPRAZOLE ON THE pH AND VOLUME OF GASTRIC CONTENTS BEFORE SURGERY

EFFECT OF I.V. OMEPRAZOLE ON THE pH AND VOLUME OF GASTRIC CONTENTS BEFORE SURGERY

The Effect of Three Different Ranitidine Dosage Regimens on Reducing Gastric Acidity and Volume in Ambulatory Surgical Patients

Aspiration pneumonitis: Predisposing conditions and prevention

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