Ranitidine treatment inducing methemoglobinemia in male Wistar rats

Malfará, Wilson Roberto; Souza, Ana Maria de; Queiróz, Regina Helena Costa

doi:10.1590/s1516-93322005000200013

Cited by 11 publications

(12 citation statements)

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“…This result may due to oxygen free radical scavenger of ranitidin and its ability to healing gastric ulcer and stopping of hemorrhage. this result is agreement with (64).…”

Section: Discussionsupporting

confidence: 92%

Study the Effect of Proanthocyanidin and Ranitidine on Haematology and Biochemical Parameters in Adult Female Rabbits With Gastric Ulceration Induced by Indomethacin

AL-Masoudi¹

2016

Bas.J.Vet.Res.

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The study was conducted in Collage of Veterinary Medicine \Basrah University,to evaluate the effect of proanthocyanidin and ranitidin on gastric ulcer, haematological and biochemical parameters changes by using female rabbits with acute gastric lesions induced by indomethacin.The study done on (30)adult female rabbits, their weight ranged between (1500-2000.0mg); divided into five groups, each group consist of six rabbits as the following: Group1:-healthy (negative control group) administrated normal saline (0.9 of normal saline) for 10 days; Group 2:-given indomethacin 75mg\kg B.W. for two days(positive control group); Group 3:-at first given indomethacin 75mg\kg B.W. for two days, then treated with proanthocyanidin(PA) 100mg\kg B.W. for 10 days; Group 4, initially given indomethacin 75mg\kg for two days, then treated with proanthocyanidin(PA) 200mg\kg for 10 days; Group 5, given indomethacin 75mg\kg for two days, then treated with ranitidin 50mg\kg for10 days.The results showed that proanthocyanidin(PA) and ranitidin caused significant reduction (P≤0.05) in gastric volume, ulcer area, serum MDA, gastric tissue MDA while significant increase (P≤0.05) in mucin and gastric pH. It also revealed significant decrease (P≤0.05) in glucose concentration in rabbits treated with proanthocyanidin compared to positive control group while showedno-significant change in glucose concentration in rabbits treated with ranitidine compared with positive control group. It also, showed ISI Impact Factor:3.461 . 133 significant increase (P≤0.05) in Red Blood Cell(RBC),Hemoglobin(Hb) andMean Corpuscle hemoglobin concentration(MCHC) in rabbit treated with proanthocyanidin or ranitidin, while there was significant decrease (P≤0.05) in Mean Corpuscle Volume(MCV) in rabbits treated with proanthocyanidin in dose of 100mg\kgand ranitidine in a dose of 50mg/kg with non-significant change of MCV in female rabbits with gastric ulceration treated with proanthocyanidin at dose 200 compared with positive control group.It showed non-significant changes in White Blood Cell (WBC) of female rabbits with gastric ulceration treated with proanthocyanidin compared with positive and negative control groups, while the results showed significant decrease (P≤0.05) in WBC of female rabbits with gastric ulceration treated with ranitidine group compared with positive and negative control groups and the other groups. The study revealed significant decrease (P≤0.05) in total cholesterol, triglyceride, Low Density Lipoprotein(LDL) and very Low Density Lipoprotein(VLDL) of female rabbits with gastric ulceration treated with proanthocyanidin and ranitidine group compared with positive control group while it showed significant increase (P≤0.05) in High Density Lipoprotein (HDL) in rabbits treated with proanthocyanidin and ranitidine group compared with positive control group. It is concluded that proanthocyanidin extract of the grape seeds(Vitis vinifera)displayed good antiulcer activity, hypoglycemia effect, amelioration of heamatological parameters and improve dysl...

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“…This result may due to oxygen free radical scavenger of ranitidin and its ability to healing gastric ulcer and stopping of hemorrhage. this result is agreement with (64).…”

Section: Discussionsupporting

confidence: 92%

Study the Effect of Proanthocyanidin and Ranitidine on Haematology and Biochemical Parameters in Adult Female Rabbits With Gastric Ulceration Induced by Indomethacin

AL-Masoudi¹

2016

Bas.J.Vet.Res.

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“…The same effect was observed in human duodenal ulcers treated with 150mg of ranitidine every 12 hours for 2 weeks (Hrycek et al 1994) and in rats treated with a single dose of 100mg/kg (Malfará et al 2005). In the human study, few leukocytes were found, but they showed greater phagocytic activity than before treatment (Hrycek et al 1994).…”

Section: Discussionsupporting

confidence: 58%

“…Hemoglobin type was not determined in this study, but it has been reported that ranitidine leads to methemoglobin formation in rats, suggesting that this drug is an inductor of this process (Malfará et al 2005). If the sheep in this study had increased methemoglobin formation, it must have been small because no change in the respiratory rate or mucous membrane color of the animals was detected.…”

Section: Discussionmentioning

confidence: 69%

“…This result is quite different from those mentioned in literature, as several studies reported negative effects of ranitidine on hematopoiesis. Thrombocytopenia, granulocytopenia, and hemolytic anemia have all been reported in rats receiving intraperitoneal ranitidine (Malfará et al 2005), and thrombocytopenia has been reported in humans treated with this drug (Spychal & Wickham 1985, Amos et al 1987. A review states that thrombocytopenia caused by H2-antagonist use was attributed to the direct suppression of bone marrow combined with the development of antibodies against platelets (Wade et al 2002).…”

Section: Discussionmentioning

confidence: 99%

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Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine

et al. 2014

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RESUMO.-[Perfil metabólico ruminal e pH abomasal em ovinos tratados com ranitidina por via intravenosa.] A ovinocultura brasileira tem se intensificado, o que predispõe os animais à maior incidência de transtornos digestivos, como a úlcera de abomaso. A ranitidina é utilizada na prevenção e tratamento desta afecção, no entanto há pouca informação sobre a indicação parenteral deste fármaco para ruminantes adultos. São escassas as informações a respeito das alterações metabólicas e do comportamento do sistema digestório associados ao seu uso. Para este estudo foram utilizados cinco ovinos, machos, hígidos, providos de cânula ruminal e abomasal. O delineamento foi Quadrado Latino 5x5 com arranjo fatorial de tratamentos 2x2+1. Os ovinos tratados com as doses de 1 e 2mg/kg de ranitidina administrada por via intravenosa a cada 8 ou 12 horas foram comparados aos animais do grupo controle, Brazilian sheep production has intensified, predisposing sheep to an increased incidence of digestive disorders, such as abomasal ulcers. Ranitidine is used to prevent and treat this disease; however, there is little information on the parenteral use of this drug in adult ruminants. Few data exist on the concomitant metabolic changes and the behavior of the digestive system associated with its use. For this study, five healthy male sheep with ruminal and abomasal cannulas were used. A 5x5 Latin square experiment with a 2x2+1 factorial arrangement of the treatments was performed. Sheep treated with drug doses of 1 or 2mg/kg ranitidine administered intravenously every 8 or 12 hours were compared with the control group, was treated intravenously with 1 mL of physiological solution per 25 kg every 12 hours. Higher total protein concentrations, hemoglobin levels, as well as increased aspartate aminotransferase activity and increased abomasal pH for up to 150 min following drug administration were observed in all animals that received the drug, regardless of dose and frequency. The animals treated every 12 hours showed a decrease in leukocyte number compared with the control group and with the animals treated every 8 hours. Increased serum creatinine concentrations were observed in the animals treated every 8 hours. Treatments of 1mg/kg every 8 hours and 2mg/kg every 12 hours increased the red blood cell count and decreased the serum pepsinogen. All protocols studied were safe for healthy sheep, but 1mg/kg ranitidine every 8 hours and 2mg/kg ranitidine every 12 hours were the most effective protocols for gastric protection.

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“…Efeitos colaterais têm sido relatados com baixa incidência e, dentre eles, casos de hepatite mista e hepatite colestática ocorrem geralmente por hipersensibilidade (BERTACCINI; SCARPIGNATO, 1982;MALFARÁ;SOUZA;QUEIROZ, 2005).…”

Section: Ranitidinaunclassified

Avaliação ultrassonográfica, radiológica e do perfil metabólico de ovinos tratados com diferentes protocolos de administração de ranitidina

Morgado¹

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Ranitidine treatment inducing methemoglobinemia in male Wistar rats

Abstract: Drug idiosyncrasy is an adverse event of unknown etiology that occurs in a small fraction of people taking a drug. The histamine-2 (H2)-

Cited by 11 publications

References 11 publications

Study the Effect of Proanthocyanidin and Ranitidine on Haematology and Biochemical Parameters in Adult Female Rabbits With Gastric Ulceration Induced by Indomethacin

Study the Effect of Proanthocyanidin and Ranitidine on Haematology and Biochemical Parameters in Adult Female Rabbits With Gastric Ulceration Induced by Indomethacin

Metabolic profile and ruminal and abomasal pH in sheep subjected to intravenous ranitidine

Avaliação ultrassonográfica, radiológica e do perfil metabólico de ovinos tratados com diferentes protocolos de administração de ranitidina

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