In the years, several approaches for human reliability analysis (HRA) have been developed. The aim of the present research is to propose a hybrid model to evaluate Human Error Probability (HEP). The new approach is based on logit-normal distribution, Nuclear Action Reliability Assessment (NARA), and Performance Shaping Factors (PSFs) relationship. In the research, shortcomings related to literature approaches are analyzed, especially the limitations of the working time. For this reason, PSFs after 8 hours (work standard) during emergency conditions were estimated. Therefore, the correlation between the advantages of these three methodologies allows proposing a HEP analysis during accident scenarios and emergencies; a fundamental issue to ensure the safety and reliability in industrial plants is emergency Mmnagement (EM). Applying EM methodology, two main aspects are analyzed: system reliability and human reliability. System reliability is strongly related to the reliability of its weakest component. During incidental situations, the weakest parts of the whole system are workers (human reliability) and accidental scenarios influence the operator’s ability to make decisions. This article proposes a new approach called Logit Human Reliability (LHR) that considers internal and external factors to estimate human reliability during emergencies. LHR has been applied in a pharmaceutical accident scenario, considering 24 hours of working time (more than 8 working hours). The results highlighted that the LHR method gives output data more in conformity with data banks than the conventional methods during the stress phase in an accident scenario.