RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells.

Kimata, Hajime; Yoshida, Akira; Ishioka, Chihiro; Fujimoto, M; Lindley, I. J. D.; Furusho, Kenshi

doi:10.1084/jem.183.5.2397

Cited by 99 publications

(57 citation statements)

References 30 publications

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“…Recently, it has been shown that RANTES and MIP-1␣ can enhance IgE and IgG4 production by IL-4 and anti-CD40 or anti-CD58 mAb-stimulated human sIgE ϩ and sIgG4 ϩ B cells (57). One could suggest that these effects observed in vitro with human B cell IgG4 and IgE responses do not reflect how RANTES affects host immune responses in vivo.…”

Section: Discussionmentioning

confidence: 74%

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Lillard

Boyaka

Taub

et al. 2001

The Journal of Immunology

106

105

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RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of RANTES in adaptive mucosal immunity has not been studied. To better elucidate the role of this chemokine, we have characterized the effects of RANTES on mucosal and systemic immune responses to nasally coadministered OVA. RANTES enhanced Ag-specific serum Ab responses, inducing predominately anti-OVA IgG2a and IgG3 followed by IgG1 and IgG2b subclass Ab responses. RANTES also increased Ag-specific Ab titers in mucosal secretions and these Ab responses were associated with increased numbers of Ab-forming cells, derived from mucosal and systemic compartments. Splenic and mucosally derived CD4+ T cells of RANTES-treated mice displayed higher Ag-specific proliferative responses and IFN-γ, IL-2, IL-5, and IL-6 production than control groups receiving OVA alone. In vitro, RANTES up-regulated the expression of CD28, CD40 ligand, and IL-12R by Ag-activated primary T cells from DO11.10 (OVA-specific TCR-transgenic) mice and by resting T cells in a dose-dependent fashion. These studies suggest that RANTES can enhance mucosal and systemic humoral Ab responses through help provided by Th1- and select Th2-type cytokines as well as through the induction of costimulatory molecule and cytokine receptor expression on T lymphocytes. These effects could serve as a link between the initial innate signals of the host and the adaptive immune system.

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Section: Discussionmentioning

confidence: 74%

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Lillard

Boyaka

Taub

et al. 2001

The Journal of Immunology

106

105

View full text Add to dashboard Cite

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“…Some bystander effects on the CD123 Ϫ MDC-containing fraction were also observed. More strikingly, cells from ISS-ODN-injected LNs spontaneously secreted elevated levels of cytokines and chemokines (upon culture) that would promote DC and B cell activation in addition to the recruitment of leukocytes into the lymphoid tissues to favor cell-cell communication critical for effective immune activation (48,(91)(92)(93)(94)(95)(96). This is similar to the report in humans describing elevated serum chemokine levels following s.c. injection of a CpG-B ISS-ODN (97).…”

Section: Discussionmentioning

confidence: 99%

Local and Systemic Effects of Intranodally Injected CpG-C Immunostimulatory-Oligodeoxyribonucleotides in Macaques

Teleshova

Kenney

Nest

et al. 2006

The Journal of Immunology

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Immunostimulatory CpG-C oligodeoxyribonucleotides (ISS-ODNs) represent a promising strategy to enhance vaccine efficacy. We have shown that the CpG-C ISS-ODN C274 stimulates macaque blood dendritic cells (DCs) and B cells and augments SIV-specific IFN-γ responses in vitro. To further explore the potential of C274 for future vaccine studies, we assessed the in vivo effects of locally administered C274 (in naive and healthy infected macaques). Costimulatory molecules were marginally increased on DCs and B cells within cells isolated from C274-injected lymph nodes (LNs). However, cells from C274-injected LNs exhibited heightened responsiveness to in vitro culture. This was particularly apparent at the level of CD80 (less so CD86) expression by CD123+ plasmacytoid DCs and was further boosted in the presence of additional C274 in vitro. Notably, cells from C274-injected LNs secreted significantly elevated levels of several cytokines and chemokines upon in vitro culture. This was more pronounced when cells were exposed to additional stimuli in vitro, producing IFN-α, IL-3, IL-6, IL-12, TNF-α, CCL2, CCL3, CCL5, and CXCL8. Following C274 administration in the absence of additional SIV Ag, endogenous IFN-γ secretion was elevated in LN cells of infected animals, but SIV-specific responses were unchanged. Endogenous and SIV-specific responses decreased in blood, before the SIV-specific responses rebounded by 2 wk after C274 treatment. Elevated IFN-α, CCL2, and CCL5 were also detected in the plasma after C274 injection. Thus, locally administered C274 has local and systemic activities, supporting the potential for CpG-C ISS-ODNs to boost immune function to enhance anti-HIV vaccine immunogenicity.

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“…RANTES is expressed in activated T lymphocytes, airway epithelial cells, platelets, fibroblasts, and renal epithelial and mesangial cells [6]. RANTES has also been shown to enhance the production of IgE and IgG4 by activated B cells [7]. In addition, RANTES recruits eosinophils and T cells into the airways during asthma [8] and allergic airway disease [9] and it may contribute to their immunopathology [10].…”

Section: Introductionmentioning

confidence: 99%

RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma

Sohn

Kim

et al. 2007

Lung

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Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease. The aim of this study was to evaluate the possible role of RANTES promoter polymorphisms in children with asthma. We genotyped 271 children with atopic asthma, 55 children with nonatopic asthma, and 253 control children for allelic determinants at two polymorphic sites in the promoter region at positions -403G[A and -28C[G by restriction fragment length polymorphism methods. There was no significant difference in genotype and allele frequencies of the RANTES -403G[A and -28C[G polymorphisms when the atopic asthma, nonatopic asthma, and control groups were compared. However, atopic asthmatic patients who were homozygous GG for the RANTES -28C[G tended to have lower PC 20 methacholine than those carrying the wild genotype. In addition, a significantly lower PC 20 was demonstrated for the homozygous haplotype -403A/-28G in asthmatic children. The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.

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RANTES and macrophage inflammatory protein 1 alpha selectively enhance immunoglobulin (IgE) and IgG4 production by human B cells.

Cited by 99 publications

References 30 publications

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

RANTES Potentiates Antigen-Specific Mucosal Immune Responses

Local and Systemic Effects of Intranodally Injected CpG-C Immunostimulatory-Oligodeoxyribonucleotides in Macaques

RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma

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