Rapamycin delays allograft rejection in obese graft recipients through induction of myeloid-derived suppressor cells

Deißler, Astrid; Penna, Andrea Della; Geffen, Chiel van; González-Menéndez, Irene; Quintanilla-Martı́nez, Leticia; Günther, Anna; Schneiderhan‐Marra, Nicole; Hartl, Dominik; Nürnberg, Bernd; Königsrainer, Alfred; Quante, Markus

doi:10.1016/j.imlet.2021.05.003

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Intriguingly, the adoptive transfer of MDSC from rapamycin-treated recipients prolonged allograft survival in third-party recipient mice (31). Most recently, delayed allograft rejection following MDSC induction by rapamycin has been shown in obese transplant recipients, emphasizing on the effectiveness of rapamycin in transplant recipients with preexisting conditions (33). As obesity has been linked to cellular senescence, those findings are of particular interest for the assessment of the role that MDSC may play in aging (40)(41)(42).…”

Section: Impact Of Immunosuppressive Drugs On Mdscmentioning

confidence: 99%

Aging Affects the Role of Myeloid-Derived Suppressor Cells in Alloimmunity

et al. 2022

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Myeloid-derived suppressor cells (MDSC) are defined as a group of myeloid cells with potent immunoregulatory functions that have been shown to be involved in a variety of immune-related diseases including infections, autoimmune disorders, and cancer. In organ transplantation, MDSC promote tolerance by modifying adaptive immune responses. With aging, however, substantial changes occur that affect immune functions and impact alloimmunity. Since the vast majority of transplant patients are elderly, age-specific modifications of MDSC are of relevance. Furthermore, understanding age-associated changes in MDSC may lead to improved therapeutic strategies. Here, we provide a comprehensive update on the effects of aging on MDSC and discuss potential consequences on alloimmunity.

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Section: Impact Of Immunosuppressive Drugs On Mdscmentioning

confidence: 99%

Aging Affects the Role of Myeloid-Derived Suppressor Cells in Alloimmunity

et al. 2022

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“…Also, in immunological hepatic injury, rapamycin treatment was found to promote MDSC recruitment, generation, and activity, and ameliorated the disease ( 72 ). Recently, our group demonstrated the allograft survival prolonging properties of rapamycin in obese mice through increased M-MDSCs number and activity ( 73 ). Taken together, rapamycin seems to be an efficient inductor of MDSC generation and activation, with the advantage of already being approved for clinical use for certain diseases.…”

Section: Pharmacological Approaches To Modulate Mdscsmentioning

confidence: 99%

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

2022

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent suppressive and regulative properties. MDSCs’ strong immunosuppressive potential creates new possibilities to treat chronic inflammation and autoimmune diseases or induce tolerance towards transplantation. Here, we summarize and critically discuss different pharmacological approaches which modulate the generation, activation, and recruitment of MDSCs in vitro and in vivo, and their potential role in future immunosuppressive therapy.

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Novel approach for enhancing skin allograft survival by bioadhesive nanoparticles loaded with rapamycin

Liu,

Ouyang,

et al. 2024

International Journal of Pharmaceutics

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Rapamycin delays allograft rejection in obese graft recipients through induction of myeloid-derived suppressor cells

Cited by 3 publications

References 48 publications

Aging Affects the Role of Myeloid-Derived Suppressor Cells in Alloimmunity

Aging Affects the Role of Myeloid-Derived Suppressor Cells in Alloimmunity

Pharmacological modulation of myeloid-derived suppressor cells to dampen inflammation

Novel approach for enhancing skin allograft survival by bioadhesive nanoparticles loaded with rapamycin

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