Rapamycin functionalized carbon Dots: Target-oriented synthesis and suppression of vascular cell senescence

Dong, Jiaxin; Wang, Qi; Gu, Tingting; Liu, Guanxiong; Petrov, Yuri V.; Baulin, Vladimir E.; Yu Tsivadze, Aslan; Jia, Dechang; Zhou, Yu; Yuan, Huiping; Li, Baoqiang

doi:10.1016/j.jcis.2024.01.032

Cited by 2 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After rigorous examination, it was discovered that TPP copoly -CDs prepared with 0.49 mmol of CS, 0.93 mmol of Ally-TPP, 6.26 mmol of AM (0.15 molar ratio of Allyl-TPP to AM), and 0.018 mmol of APS achieved a high synthetic yield (56 ± 1.41%) with excellent fluorescence performance. Furthermore, since CS has ROS scavenging capacity, TPP homopoly -CDs containing CS also have ROS scavenging capacity. − Nevertheless, TPP homopoly -CDs have lower RFQY and poor mitochondrial targeting ability compared to TPP copoly -CDs due to their low contents of TPP. To obtain favorable mitochondrial targeting, only TPP copoly -CDs synthesized by target-oriented random copolymerization in combination with hydrothermal carbonization in one step with the above ratios were selected for subsequent studies.…”

Section: Resultsmentioning

confidence: 99%

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Li,

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Triphenylphosphine functionalized carbon dots (TPP-CDs) showcase robust mitochondria targeting capacity owing to their positive electrical properties. However, TPP-CDs typically involve complicated synthesis steps and time-consuming postmodification procedures. Especially, the one-step target-oriented synthesis of TPP-CDs and the regulation of TPP linkage modes remain challenges. Herein, we propose a free-radical-initiated random copolymerization in combination with hydrothermal carbonation to regulate the TPP backbone linkage for target-oriented synthesis of triphenylphosphine copolymerization carbon dots (TPPcopoly-CDs). The linkage mechanism of random copolymerization reactions is directional, straightforward, and controllable. The TPP content and IC50 of hydroxyl radicals scavenging ability of TPPcopoly-CDs are 53 wt % and 0.52 mg/mL, respectively. TPP serves as a charge control agent to elevate the negatively charged CDs by 20 mV. TPPcopoly-CDs with negative charge can target mitochondria, and in the corresponding mechanism the TPP moiety plays a crucial role in targeting mitochondria. This discovery provides a new perspective on the controlled synthesis, TPP linkage modes, and mitochondrial targeting design of TPP-CDs.

show abstract

Section: Resultsmentioning

confidence: 99%

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Li,

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Dong,

Wang,

Chen

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving the ROS‐induced toxicity therapy mediated by ROS producers and antioxidant therapy by ROS scavengers. Nanotechnology advancements have led to the development of numerous nanomaterials with ROS‐modulating capabilities, among which carbon dots (CDs) standing out as noteworthy ROS‐modulating nanomedicines own their distinctive physicochemical properties, high stability, and excellent biocompatibility. Despite progress in treating ROS‐related diseases based on CDs, critical issues such as rational design principles for their regulation remain underexplored. The primary cause of these issues may stem from the intricate amalgamation of core structure, defects, and surface states, inherent to CDs, which poses challenges in establishing a consistent generalization. This review succinctly summarizes the recently progress of ROS‐modulated approaches using CDs in disease treatment. Specifically, it investigates established therapeutic strategies based on CDs‐regulated ROS, emphasizing the interplay between intrinsic structure and ROS generation or scavenging ability. The conclusion raises several unresolved key scientific issues and prominent technological bottlenecks, and explores future perspectives for the comprehensive development of CDs‐based ROS‐modulating therapy.

show abstract

Rapamycin functionalized carbon Dots: Target-oriented synthesis and suppression of vascular cell senescence

Cited by 2 publications

References 63 publications

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Target-Oriented Synthesis of Triphenylphosphine Functionalized Carbon Dots with Negative Charge for ROS Scavenging and Mitochondrial Targeting

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Contact Info

Product

Resources

About