Rapid 1024-Pixel Electrochemical Imaging at 10,000 Frames Per Second Using Monolithic CMOS Sensor and Multifunctional Data Acquisition System

White, Kevin A.; Mulberry, Geoffrey; Kim, Brian N.

doi:10.1109/jsen.2018.2835829

Cited by 18 publications

(13 citation statements)

References 22 publications

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“…In Table 2, a comparison is presented among state-of-the-art electrochemical CMOS arrays interfaced to electrical current sensors. As can be seen therein, a number of the reported systems, such as Jafari et al (2014) and White et al (2018), can cover signal bandwidths (BWs) over 1 kHz, a figure close to the translocation rates being handled by existing commercial-grade nanopore (MinION row in Table 2) electrochemical cells (Bowden et al 2019). To-date, biopore-based constructions of commercial electrochemical cells have met with the most success for practical DNA sequencing.…”

Section: Resistive Pulse Shaping Sensor Arraysmentioning

confidence: 92%

Nanopore-based DNA sequencing sensors and CMOS readout approaches

Habibi

Dawji

Ghafar-Zadeh

et al. 2021

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Purpose Nanopore-based molecular sensing and measurement, specifically DNA sequencing, is advancing at a fast pace. Some embodiments have matured from coarse particle counters to enabling full human genome assembly. This evolution has been powered not only by improvements in the sensors themselves, but also in the assisting microelectronic CMOS readout circuitry closely interfaced to them. In this light, this paper aims to review established and emerging nanopore-based sensing modalities considered for DNA sequencing and CMOS microelectronic methods currently being used. Design/methodology/approach Readout and amplifier circuits, which are potentially appropriate for conditioning and conversion of nanopore signals for downstream processing, are studied. Furthermore, arrayed CMOS readout implementations are focused on and the relevant status of the nanopore sensor technology is reviewed as well. Findings Ion channel nanopore devices have unique properties compared with other electrochemical cells. Currently biological nanopores are the only variants reported which can be used for actual DNA sequencing. The translocation rate of DNA through such pores, the current range at which these cells operate on and the cell capacitance effect, all impose the necessity of using low-noise circuits in the process of signal detection. The requirement of using in-pixel low-noise circuits in turn tends to impose challenges in the implementation of large size arrays. Originality/value The study presents an overview on the readout circuits used for signal acquisition in electrochemical cell arrays and investigates the specific requirements necessary for implementation of nanopore-type electrochemical cell amplifiers and their associated readout electronics.

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Section: Resistive Pulse Shaping Sensor Arraysmentioning

confidence: 92%

Nanopore-based DNA sequencing sensors and CMOS readout approaches

Habibi

Dawji

Ghafar-Zadeh

et al. 2021

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“…Biological nanopore experiments need tens of kHz bandwidth. A notable current readout array with 10 kHz bandwidth is presented in [31]. However, this contribution cannot be used with large input capacitance seen in nanopore sensors due to its amplifier topology.…”

Section: Nanopore-based Dna Sequencingmentioning

confidence: 99%

A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing

et al. 2021

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“…Vpos is generated in an on-chip voltage regulator and is set to ~1.5 V, to put the DC operating point of the circuit near the middle of the amplifiers' dynamic range. The OPAs used in this design are a cascode differential amplifier with PMOS inputs [21]- [23]. Using capacitors as the feedback elements allows for the amplifier's gain to be independent of frequency.…”

Section: A Neural Amplifier Circuitrymentioning

confidence: 99%

A Wirelessly Powered Implantable CMOS Neural Recording Sensor Array using Pulse-based Neural Amplifier

Mulberry

White

Kim

2019

Preprint

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The most important organ in the human body is unquestionably the brain. Yet, despite its importance, it is one of the least well understood organs. One reason for this lack of understanding of the brain is the lack of data available to researchers from in vivo studies. Historically, collecting measurements from the brain has been difficult due to the high risk to the patient. Recently technology has been developed to allow electrical measurements to be taken from the brain directly, however most systems involve non-permanent sensors because of the requirement for transcranial wiring for power and data. Developments in the field of CMOS circuit design, wireless power transmission, and wireless data transmission have enabled the creation of implantable neural recording devices as a combination of these technologies. The implant designed in this paper is ~15 mm in diameter and 2 mm at its thickest point on a flexible polyamide PCB. The flexible nature of the implant allows for the implant to conform to the surface of the brain. The implant requires no transcranial orifice since it is powered wirelessly and transmits data wirelessly via Bluetooth low energy. The CMOS neural amplifier chip on the implant utilizes an enhanced form of delta modulation to remove the requirement for large ADCs to be present on the die, saving space and enabling 1024 amplifiers and electrodes to be present on the chip. The implant is capable of measuring, modulating, and wirelessly transmitting a millivolt order signal to a PC for demodulation and analysis.

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Rapid 1024-Pixel Electrochemical Imaging at 10,000 Frames Per Second Using Monolithic CMOS Sensor and Multifunctional Data Acquisition System

Cited by 18 publications

References 22 publications

Nanopore-based DNA sequencing sensors and CMOS readout approaches

Nanopore-based DNA sequencing sensors and CMOS readout approaches

A Scalable Discrete-Time Integrated CMOS Readout Array for Nanopore Based DNA Sequencing

A Wirelessly Powered Implantable CMOS Neural Recording Sensor Array using Pulse-based Neural Amplifier

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