Rapid Actions of 1 -25-Dihydroxyvitamin D3 Physiologic Role

Baran, Daniel T.; Sorensen, A. M.

doi:10.3181/00379727-207-43803

Cited by 18 publications

(6 citation statements)

References 13 publications

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“…Membrane-binding sites for vitamin D 3 have been described in chick intestine (86, 87) and ROS 24/1 cells (10)(11)(12). In chick intestine, studies with analogues of vitamin D 3 [particularly 1,25(OH)2-7-dehydrocholesterol and 1,25(OH)2-lumisterol3] have provided convincing correlations between the protein binding to the solubilized membrane receptor and its ability to initiate the rapid hormonal stimulation of calcium transport.…”

Section: Vitamin Dmentioning

confidence: 99%

Specific, Nongenomic Actions of Steroid Hormones

Wehling

1997

Annu. Rev. Physiol.

622

336

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Traditionally, steroid hormone action has been described as the modulation of nuclear transcription, thus triggering genomic events that are responsible for physiological effects. Despite early observations of rapid steroid effects that were incompatible with this theory, nongenomic steroid action has been widely recognized only recently. Evidence for these rapid effects is available for steroids of all clones and for a multitude of species and tissues. Examples of nongenomic steroid action include rapid aldosterone effects in lymphocytes and vascular smooth muscle cells, vitamin D3 effects in epithelial cells, progesterone action in human sperm, neurosteroid effects on neuronal function, and vascular effects of estrogens. Mechanisms of action are being studied with regard to signal perception and transduction, and researchers have developed a patchy sketch of a membrane receptor-second messenger cascade similar to those involved in catecholamine and peptide hormone action. Many of these effects appear to involve phospholipase C, phosphoinositide turnover, intracellular pH and calcium, protein kinase C, and tyrosine kinases. The physiological and pathophysiological relevance of these effects is unclear, but rapid steroid effects on cardiovascular, central nervous, and reproductive functions may occur in vivo. The cloning of the cDNA for the first membrane receptor for steroids should be achieved in the near future, and the physiological and clinical relevance of these rapid steroid effects can then be established.

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Section: Vitamin Dmentioning

confidence: 99%

Specific, Nongenomic Actions of Steroid Hormones

Wehling

1997

Annu. Rev. Physiol.

622

336

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“…MARRSBP was identified, purified and cloned from chick intestinal epithelium [60]. MARRSBP has also been found in tissues, including osteoblasts, liver, adipocytes and muscle [61,62,63,64,65,66,67]. MARRSBP acts via a G protein-coupled process that activates phospholipase C. Phospholipase C hydrolyzes membrane-bound phosphoinositol bisphosphate (PIP 2 ) to release inositol trisphosphate (IP 3 ) and diacylglycerol.…”

Section: Vitamin D: Introduction Function and Metabolismmentioning

confidence: 99%

Molecular Link between Vitamin D and Cancer Prevention

2013

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The metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (also known as calcitriol), is a biologically active molecule required to maintain the physiological functions of several target tissues in the human body from conception to adulthood. Its molecular mode of action ranges from immediate nongenomic responses to longer term mechanisms that exert persistent genomic effects. The genomic mechanisms of vitamin D action rely on cross talk between 1α,25-dihydroxyvitamin D3 signaling pathways and that of other growth factors or hormones that collectively regulate cell proliferation, differentiation and cell survival. In vitro and in vivo studies demonstrate a role for vitamin D (calcitriol) in modulating cellular growth and development. Vitamin D (calcitriol) acts as an antiproliferative agent in many tissues and significantly slows malignant cellular growth. Moreover, epidemiological studies have suggested that ultraviolet-B exposure can help reduce cancer risk and prevalence, indicating a potential role for vitamin D as a feasible agent to prevent cancer incidence and recurrence. With the preventive potential of this biologically active agent, we suggest that countries where cancer is on the rise—yet where sunlight and, hence, vitamin D may be easily acquired—adopt awareness, education and implementation strategies to increase supplementation with vitamin D in all age groups as a preventive measure to reduce cancer risk and prevalence.

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“…However, several authors have observed specific nuclear VDR and corresponding mRNA in osteoclastic cell types (29–31) . On the other hand, some of the 1,25(OH) 2 D 3 actions on osteoclasts have been proposed to be mediated by a mechanism that does not require binding to a nuclear VDR (28,32) but rather by interaction with a membrane‐associated protein capable of activating signal transduction pathways, which might in turn alter nuclear function. These mechanisms have been delineated most clearly in osteoblasts and osteoblast‐like cells in vitro in which 1,25(OH) 2 D 3 induces increments in cellular calcium in rat osteosarcoma cells (33,34) .…”

Section: Introductionmentioning

confidence: 99%