Purpose of Project To translate an evidence-based Clostridioides difficile* (CDI) treatment clinical pathway using a systematic, transparent process into machine readable clinical decision support (CDS) prototyped for electronic health record (EHR) integration. (*The bacterium Clostridium difficile was renamed Clostridioides difficile in August 2016.) Key Messages • Getting evidence into practice to improve clinical decision making remains an ongoing challenge. • We successfully translated a clinical pathway into machine readable CDS prototyped for EHR integration. • We used the CDS Authoring Tool on the CDS Connect website to translate this clinical pathway into Clinical Quality Language (CQL) shareable decision support. • Creating CDS artifacts from a clinical pathway informed by an EPC report may promote dissemination of work from AHRQ reports to a wide audience and support AHRQ's Learning Health System initiatives. iii This report is based on research conducted by the ECRI Institute-Penn Medicine Evidencebased Practice Center (EPC) under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-2015-00005-I). The findings and conclusions in this document are those of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Service None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. The information in this report is intended to help healthcare decision makers-patients and clinicians, health system leaders, and policymakers, among others-make well-informed decisions and thereby improve the quality of healthcare services. This report is not intended to be a substitute for the application of clinical judgment. Anyone who makes decisions concerning the provision of clinical care should consider this report in the same way as any medical reference and in conjunction with all other pertinent information, i.e., in the context of available resources and circumstances presented by individual patients. This report is made available to the public under the terms of a licensing agreement between the author and the Agency for Healthcare Research and Quality. This report may be used and reprinted without permission except those copyrighted materials that are clearly noted in the report. Further reproduction of those copyrighted materials is prohibited without the express permission of copyright holders. AHRQ or U.S. Department of Health and Human Services endorsement of any derivative products that may be developed from this report, such as clinical practice guidelines, other quality enhancement tools, or reimbursement or coverage policies, may not be stated or implied.