Rapid analysis of liquid formulations containing sodium chloride using laser-induced breakdown spectroscopy

St‐Onge, L.; Kwong, Elizabeth; Sabsabi, Mohamad; Vadas, Elizabeth B.

doi:10.1016/j.jpba.2004.06.004

Cited by 155 publications

(84 citation statements)

References 20 publications

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“…More recently, St-Onge et al 284 demonstrated the possibilities offered by LIBS for the direct and rapid analysis of liquid pharmaceutical formulations. They chose sodium chloride in solution as a model compound.…”

Section: Application To Pharmaceutical Productsmentioning

confidence: 99%

Laser Induced Breakdown Spectroscopy

Pasquini¹,

Cortez²,

Silva³

et al. 2007

J. Braz. Chem. Soc.

342

195

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Esta revisão descreve os aspectos fundamentais, a instrumentação, as aplicações e tendências futuras de uma técnica analítica que se encontra em seu estágio de consolidação e que está em vias de estabelecer o seu nicho entre as técnicas espectrofotométricas modernas. A técnica é denominada Espectroscopia de Emissão em Plasma Induzido por Laser (em inglês, Laser Induced Breakdown Spectroscopy, LIBS) e sua principal característica está no uso de pulsos de laser como fonte de energia para vaporizar a amostra e excitar a emissão de radiação eletromagnética, a partir de seus elementos e/ou fragmentos moleculares. A radiação emitida é analisada por meio de instrumentos ópticos de alta resolução e as suas intensidades são medidas, usualmente com detectores rápidos de estado sólido. Em conjunto, esses dispositivos permitem a geração e a medida de um espectro de emissão de faixa ampla do fenômeno induzido pelo pulso de laser. O espectro registrado contém informação qualitativa e quantitativa que pode ser correlacionada com a identidade da amostra ou empregada na determinação da quantidade de seus constituintes. Essa revisão é dividida em quatro partes. A primeira aborda aspectos históricos da técnica e os conceitos teóricos relevantes associados com LIBS; então, os aspectos práticos de diversas abordagens experimentais e instrumentais empregadas na implementação da técnica são revistos de forma crítica; as aplicações encontradas na literatura, incluindo aquelas que empregam quimiometria, são classificadas e exemplificadas por meio de trabalhos relevantes recentemente publicados. Finalmente, uma tentativa de estabelecer uma avaliação global e as perspectivas futuras para a técnica é apresentada.This review describes the fundamentals, instrumentation, applications and future trends of an analytical technique that is in its early stages of consolidation and is establishing its definitive niches among modern spectrometric techniques. The technique has been named Laser Induced Breakdown Spectroscopy (LIBS) and its main characteristic stands in the use of short laser pulses as the energy source to vaporize samples and excite the emission of electromagnetic radiation from its elements and/or molecular fragments. The emitted radiation is analyzed by high resolution optics and the intensities are recorded, usually by fast triggered solid state detectors. Together, these devices allow producing and registering a wide ranging emission spectrum of the short-lived phenomenon induced by the laser pulse. The spectrum contains qualitative and quantitative information which can be correlated with sample identity or can be used to determine the amount of its constituents. This review is divided in four parts. First, the relevant historical and theoretical concepts associated with LIBS are presented; then the main practical aspects of the several experimental and instrumental approaches employed for implementation of the technique are critically described; the applications related in the literature, including those making use of chemometri...

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Section: Application To Pharmaceutical Productsmentioning

confidence: 99%

Laser Induced Breakdown Spectroscopy

Pasquini¹,

Cortez²,

Silva³

et al. 2007

J. Braz. Chem. Soc.

342

195

View full text Add to dashboard Cite

show abstract

“…Several excellent review articles [8][9][10][12][13][14][15][16] regarding LIBS fundamentals, applications and experimental approaches have been published. LIBS is a very versatile analytical technique, and has been employed in numerous industrial [17][18][19], environmental [20][21][22] and archaeological [23][24][25] applications, to give but a few examples.…”

Section: Introductionmentioning

confidence: 99%

Hardness determination of bio-ceramics using Laser-Induced Breakdown Spectroscopy

Cowpe

Moorehead

Moser

et al. 2011

Spectrochimica Acta Part B: Atomic Spectroscopy

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Abstract:Laser-Induced Breakdown Spectroscopy (LIBS) was applied to the analysis of bioceramic samples. The relationship between sample hardness and LIBS plasma properties was investigated, with comparison to conventional Vickers hardness measurements. The plasma excitation temperature T e was determined using the lineto-continuum ratio for the Si (I) 288.16 nm emission line; we have demonstrated a linear relationship between sample surface hardness and plasma temperature. Results indicate that hardness determination based on measurements of T e offers greater reproducibility than Vickers hardness measurements, under the conditions considered here. The validity of spectroscopic diagnostics based on LTE was confirmed.

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“…Also splashing, waves, bubbles and aerosols caused by the shockwave accompanying the plasma formation effects precision and analytical performance. In order to overcome these problems, there are various procedures for liquid samples like analysing the surface of a static liquid body, the surface of a vertical flow of a liquid, the surface of a vertical flow of a liquid or of infalling droplets, the bulk of a liquid or dried sample of the liquid deposited on a solid substrate [55]. Though the results obtained were satisfactory, but it is obvious that such experimental tricks contradict with one of the most attractive advantages of LIBS, namely working on an unprepared sample, which facilitate in-situ and real-time measurements [56].…”

Section: Laser Induced Breakdown Spectroscopy (Libs)mentioning

confidence: 99%