Rapid Analysis of Morusin from &amp;lt;i&amp;gt;Ramulus mori&amp;lt;/i&amp;gt; by HPLC-DAD, Its Distribution &amp;lt;i&amp;gt;in Vivo&amp;lt;/i&amp;gt; and Differentiation in the Cultivated Mulberry Species

Ma, Bin; Cui, Fenying; Zhang, Yuqing

doi:10.4236/fns.2013.42026

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…In our laboratory, we studied the extraction of active components such as polysaccharides [20, 21], 1-deoxynojirimycin [22], mulberroside A [19], and morusin [23] from mulberry branch bark. The results showed that the extract of mulberry branch bark has bioactivities of antioxidation [19], hypoglycaemia [24], hypolipidemia, and anticancer [25].…”

Section: Introductionmentioning

confidence: 99%

Mulberry Bark Alleviates Effect of STZ Inducing Diabetic Mice through Negatively Regulating FoxO1

Qiu

Wang

Liu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Dysfunction of insulin secretion and hyperglycaemia were commonly found due to damaged β cells of pancreas. In our previous research, it was found that mulberry branch bark powder (MBBP) was effective in treating diabetes in mice which were induced by STZ and high fat diet. The present study was designed to evaluate the protective effect of MBBP on STZ-induced β cells injury and investigate underlying mechanisms. By preventive administration of branch bark powder, the damage caused by STZ injection was found to be alleviated. In MBBP feed groups, pathological weight loss was inhibited, fasting blood glucose was controlled, the incidence of diabetes decreased, and blood lipid level and antioxidant capacities were restored. The PI3K/AKT/FoxO1 signal pathway was found to be activated by key proteins expression and gene testing. In liver, the increased PI3K and phosphorylated AKT, the phosphorylated, and inactivated FoxO1, which regulates the expression of gluconeogenic gene and explains the effect of relieving insulin resistance of MBBP. Therefore, the MBBP improves the tolerance of pancreas to the toxicity of STZ involving the PI3K/AKT/FoxO1 signalling pathway.

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Section: Introductionmentioning

confidence: 99%

Mulberry Bark Alleviates Effect of STZ Inducing Diabetic Mice through Negatively Regulating FoxO1

Qiu

Wang

Liu

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Quercetin ( (Tao et al, 2013), quercetin-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside (rutin) (23), quercetin 3-(6-malonylglucoside) (Q3MG) (24) (Katsube et al, 2010), quercetin3-(6acetylglucoside) (Q3AG) (25), kaempferol3-(6-rhamnosylglucoside) (K3RG) (26), kaempferol3-(6malonylglucoside) (K3MG) (27) (Sugiyama et al, 2013), morusin (28) (Ma et al, 2013), sanggenon C (29), sanggenon G (30), kuwanon L (31) (Cui et al, 2006) (Figure 3).…”

Section: Flavonoidsmentioning

confidence: 99%

“…Morusin (28) is an isoprenylated flavone, isolated from the root bark of M. alba; its structure has been identified (Figure 3) (Chi et al, 2001). It has been showed that morusin is present in all parts of the mulberry plant (Ma et al, 2013). The content of morusin is highest in root bark and second highest in branch bark.…”

Section: Flavonoidsmentioning

confidence: 99%

A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus

et al. 2018

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Diabetes mellitus (DM) is a serious metabolic disorder which has reached epidemic proportions all over the world. Despite tremendous developments in medicinal chemistry, traditional medicine is still commonly used for the prevention and treatment of DM. Traditional herbal medicines have been playing a major role in the management of DM in Asian countries. In particular, mulberry has commonly been utilized in China for the treatment of DM for thousands of years. In the last decade, numerous preclinical findings have suggested that mulberry is a promising therapeutic agent for the treatment of DM, and the polyhydroxylated alkaloids, flavonoids and polysaccharides from mulberry may be the potential active components. The present review systematically summarizes the chemical composition of mulberry and the pharmacological effects of different medicinal parts on DM; these effects include influences on glucose absorption, insulin (INS) production/secretion, antioxidation and anti-inflammation processes. After summarizing research findings, we discuss challenges and opportunities, and explore the direction of future research and the potential for developing mulberry into pharmaceuticals for the widespread treatment of DM.

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“…Our group had investigated in details the difference of morusin in 100 kinds of mulberry branch bark by RP-HPLC-DAD (reverse-phase high-performance liquid chromatography) with diode array detector, and the maximum amount was found to be 585.81 µg/g and 20 times to the minimum [ 22] . Similarly, morusin was found to restrain the proliferation of human hepatocarcinoma Bel-7402 cells, resulting in a survival rate of tumour cells of only 34.56% and an apoptotic rate of cancer cells reaching 81% in high concentrations with a dose-dependent manner [ 23] .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Morusin From Mulberry Branches As An Agro-Waste to MDA-MB-453 and HCT116 Cancer Cells By Inducing Cell Apoptosis and Disturbing The Cell Cycle

Zhong

Zhang

2021

Preprint

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Mulberry tree branches are one of the largest agro-wastes produced in silk industry. How to make full use of this waste has always been one of the most important issues for the silk industry and even the entire biological industry. The paper has first reported that the inhibition of morusin recovered from mulberry branch barks, a prenylated flavonoid, on 20 kinds of tumour cells, of which the IC50 values of the 80% cells reaches about 15 µM. Second, effects on the proliferation, invasion and apoptosis of two cancer cells were investigated in detail. The experimental results showed that the apoptotic ratio of the high concentration was 77.73% in MDA-MB-453 cells. Western blotting displayed that morusin upregulated E-cadherin and downregulated vimentin and N-cadherin in a dose-dependent manner, and thus reversed epithelial-mesenchymal transition. It could upregulate cleaved Caspase-3 and Bax and downregulate Caspase-3 and Bcl-2, which indicate that the cell apoptosis is induced by morusin. These cancer cells, MDA-MB-453, were blocked in G2 phase, and HCT116 were arrested in S phase when treated with morusin, which is possible that the cell cycle is disturbed. Therefore, morusin could inhibit cancer migration and growth and promote cancer cell apoptosis.

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Rapid Analysis of Morusin from <i>Ramulus mori</i> by HPLC-DAD, Its Distribution <i>in Vivo</i> and Differentiation in the Cultivated Mulberry Species

Cited by 3 publications

References 20 publications

Mulberry Bark Alleviates Effect of STZ Inducing Diabetic Mice through Negatively Regulating FoxO1

Mulberry Bark Alleviates Effect of STZ Inducing Diabetic Mice through Negatively Regulating FoxO1

A Systematic Review of the Medicinal Potential of Mulberry in Treating Diabetes Mellitus

Inhibition of Morusin From Mulberry Branches As An Agro-Waste to MDA-MB-453 and HCT116 Cancer Cells By Inducing Cell Apoptosis and Disturbing The Cell Cycle

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