Rapid analysis of quinones in complex matrices by derivatization-based wooden-tip electrospray ionization mass spectrometry

Nylon 6-cellulose composite hosted in a hypodermic needle: Biofluid extraction and analysis by ambient mass spectrometry in a single device

“…A particular substrate, sometimes called ESI-emitter, is used to create an electrospray containing the ionized analytes, allowing their transference to the MS inlet. Different substrates have been used in these developments, including paper [ 8 , 9 ], wooden tips [ 10 , 11 ], coated blades [ 12 , 13 ], threads [ [14] , [15] , [16] ], probes [ 17 , 18 ], solid phase microextraction (SPME) fibers [ 19 ], Teflon [ 20 ], graphite rods [ 21 ], volumetric absorptive microsampling [ 22 ], and needles [ 23 , 24 ].…”

Mapping of Fatty Aldehydes in the Diabetic Rat Brain Using On-Tissue Chemical Derivatization and Air-Flow-Assisted Desorption Electrospray Ionization-Mass Spectrometry Imaging

“…Chemical derivatization is frequently used as a strategy for increasing ion yields, improving chromatographic performance, and facilitating structure identification in gas chromatography tandem-mass spectrometry and liquid chromatography-mass spectrometry (LC)-MS analysis. On-tissue chemical tagging of unionizable target analytes with easily ionized moieties is an alternative means of enhancing ionization efficiency, sensitivity, and specificity in MSI experiments. − On-tissue chemical derivatization (OTCD)-MSI methods targeting fatty acids, steroid hormones, thiol peptides, amino acids, neurotransmitters, and drugs have been developed, providing important tools that are used to determine the temporal and spatial fate of these metabolites in pathological processes. − For example, Wu et al developed an electrospray-assisted OTCD method using 2-pyridinemethanamine as the derivatization reagent and mapped the distribution of endogenous fatty acids in brain tissue using OTCD-MALDI-MSI. Guo et al developed a laser-assisted tissue transfer (LATT) technique to improve the tissue derivatization of small molecules and imaged 69 derivatized metabolites, including neurotransmitters, amino acids, dipeptides, and steroids, in the rat brain using LATT derivatization with 4-hydroxy-3-methoxycinnamaldehyde and Girard’s reagent T (GT).…”

Pre-cleaned bare wooden toothpicks for the determination of drugs in oral fluid by mass spectrometry

“…Wooden-based sorbents also present rigidity and porosity. The versatility of WTs allows different sampling modalities including (i) sample deposition [20][21][22][23][24][25][26], (ii) dipping of liquid samples [27,28], (iii) puncturing solid samples [29,30], (iv) adhesion of granule/powdered samples [28,[31][32][33][34][35], and (v) conventional extraction-elution-analysis workflow [18,[36][37][38][39][40][41]. Moreover, the biocompatibility of wood derived from its lignocellulosic nature opens the door to in vivo sampling.…”