Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column

Hattori, Hideki; Ito, Kenjiro; Iwai, Masae; Arinobu, Tetsuya; Mizutani, Yoko; Kumazawa, Takeshi; Ishii, Akira; Сузукі, Осаму; Seno, Hiroshi

doi:10.1007/s11419-007-0037-3

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…The calibration curves were linear over the range 5-500 g L −1 . Hattori et al combined an LC-MS-MS instrument with a new polymer column, which enables direct injection of crude biological samples without complicated pretreatments and without a column switching system [70]. SRT, FLV, and PAR in human serum specimens were analyzed with this method.…”

Section: Ms Detectionmentioning

confidence: 99%

Analytical methodologies for the determination of sertraline

Bosch¹,

Ruiz-Sánchez²,

Rojas³

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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Section: Ms Detectionmentioning

confidence: 99%

Analytical methodologies for the determination of sertraline

Bosch¹,

Ruiz-Sánchez²,

Rojas³

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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“…Cocaine and metabolites have been detected in blood by column-switching HPLC/UV (500) (505). The pyrolysis product anhydroecgonine methyl ester was detected after cocaine smoking by GC/MS (506).…”

Section: Drugs and Poisonsmentioning

confidence: 99%

Forensic Science

Brettell¹,

Butler

Saferstein³

2005

Anal. Chem.

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“…The recoveries of the three drugs in human serum were observed as 29.2%-45.7% at 20 ng/mL and 52.0%-53.7% at 80 ng/mL of injection, and each drug had a detection limit of 1-3 ng/mL. Thus, the method enabled direct injection of crude biological samples without complicated pretreatments and without column switching system [31].…”

Section: Mass Detector Lc Coupled With Single-stage (Lc-ms) or Tandementioning

confidence: 95%

Trends and Advances in Separation and Detection of SSRIs and SNRIs in Biological Matrices

Das

Agrawal

2013

Chromatography Research International

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Nowadays antidepressant drugs like selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs) represent the first choice in the treatment of moderate to severe depressive illness, various phobias, and personality disorders. In spite of the therapeutic aspects, they often produce very severe and toxic effects in deliberate and accidental cases of poisoning. These are also considered as date-rape drugs used for drugged victims for raping or robbing. Therefore, in recent years, their analyses in different biological matrices for clinical and toxicological analysis purposes has been a target worthy of interest. Thus, the review focuses on recent advancements of various separation techniques like chromatography and electrophoresis that are concernd with the determination of selective serotonin reuptake inhibitor and selective norepinephrine reuptake inhibitor drugs and their metabolites in various biological matrices. In addition to this, a critical discussion on analytical approaches has also been incorporated, suggesting their applicability and limitations for further implementations. Thus, this paper will definitely help in the selection and development of proper analytical methodologies to achieve satisfactory results, better scientific understanding, and test interpretation.

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Rapid analysis of sertraline, fluvoxamine, and paroxetine in serum specimens by LC-MS-MS using a new polymer column

Cited by 12 publications

References 17 publications

Analytical methodologies for the determination of sertraline

Analytical methodologies for the determination of sertraline

Forensic Science

Trends and Advances in Separation and Detection of SSRIs and SNRIs in Biological Matrices

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