Rapid analysis of trace organic compounds in water by automated online solid-phase extraction coupled to liquid chromatography–tandem mass spectrometry

Anumol, Tarun; Snyder, Shane A.

doi:10.1016/j.talanta.2014.08.011

Cited by 98 publications

(38 citation statements)

References 48 publications

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“…In this paper, the analytical method was further improved by using online solid-phase extraction [20]. Briefly, aliquots of the samples collected were spiked with stable isotopes of the selected TOrC indicators, then 1.7 mL of sample was loaded onto a PLRP-S 15 μm cartridge using an Agilent 1290 FlexCube.…”

Section: Methodsmentioning

confidence: 99%

Application of surrogates, indicators, and high-resolution mass spectrometry to evaluate the efficacy of UV processes for attenuation of emerging contaminants in water

Merel

Anumol

Park

et al. 2015

Journal of Hazardous Materials

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In response to water scarcity, strategies relying on multiple processes to turn wastewater effluent into potable water are being increasingly considered by many cities. In such context, the occurrence of contaminants as well as their fate during treatment processes is a major concern. Three analytical approaches where used to characterize the efficacy of UV and UV/H2O2 processes on a secondary wastewater effluent. The first analytical approach assessed bulk organic parameters or surrogates before and after treatment, while the second analytical approach measured the removal of specific indicator compounds. Sixteen trace organic contaminants were selected due to their relative high concentration and detection frequency over eight monitoring campaigns. While their removal rate ranges from approximately 10 to >90%, some of these compounds can be used to gauge process efficacy (or failure). The third analytical approach assessed the fate of unknown contaminants through high-resolution time-of-flight (TOF) mass spectrometry with advanced data processing and demonstrated the occurrence of several thousand organic compounds in the water. A heat map clearly evidenced compounds as recalcitrant or transformed by the UV processes applied. In addition, those chemicals with similar fate were able to be grouped together into clusters to identify new indicator compounds. In this manuscript, each approach is evaluated with advantages and disadvantages compared.

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Section: Methodsmentioning

confidence: 99%

Application of surrogates, indicators, and high-resolution mass spectrometry to evaluate the efficacy of UV processes for attenuation of emerging contaminants in water

Merel

Anumol

Park

et al. 2015

Journal of Hazardous Materials

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“…The selection of ETOrCs analyzed in this study was based on data presented in previous literature that rely on occurrence data, detection frequency, availability of robust analytical methods and removal rate in conventional WWTPs [25][26][27][28][29]. Detailed information about all target analytes used in this study are shown in Table 1.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

Use of fluorescence EEM to monitor the removal of emerging contaminants in full scale wastewater treatment plants

Sgroi

Roccaro

Korshin

et al. 2017

Journal of Hazardous Materials

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149

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“…Instrumental limits of detection (LODs), method detection limits (MDLs) and sample specific method reporting limits (MRLs) were determined according to Anumol and Snyder (2015) (Tables SI-5 and SI-6). For quality control purposes, at least one laboratory blank and one laboratory blank sample fortified with the target analytes were analyzed for every 10 samples.…”

Section: Targeted Chemical Analysesmentioning

confidence: 99%

Interlaboratory comparison of in vitro bioassays for screening of endocrine active chemicals in recycled water

et al. 2015

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In vitro bioassays have shown promise as water quality monitoring tools. In this study, four commercially available in vitro bioassays (GeneBLAzer(®) androgen receptor (AR), estrogen receptor-alpha (ER), glucocorticoid receptor (GR) and progesterone receptor (PR) assays) were adapted to screen for endocrine active chemicals in samples from two recycled water plants. The standardized protocols were used in an interlaboratory comparison exercise to evaluate the reproducibility of in vitro bioassay results. Key performance criteria were successfully achieved, including low background response, standardized calibration parameters and high intra-laboratory precision. Only two datasets were excluded due to poor calibration performance. Good interlaboratory reproducibility was observed for GR bioassay, with 16-26% variability among the laboratories. ER and PR bioactivity was measured near the bioassay limit of detection and showed more variability (21-54%), although interlaboratory agreement remained comparable to that of conventional analytical methods. AR bioassay showed no activity for any of the samples analyzed. Our results indicate that ER, GR and PR, were capable of screening for different water quality, i.e., the highest bioactivity was observed in the plant influent, which also contained the highest concentrations of endocrine active chemicals measured by LC-MS/MS. After advanced treatment (e.g., reverse osmosis), bioactivity and target chemical concentrations were both below limits of detection. Comparison of bioassay and chemical equivalent concentrations revealed that targeted chemicals accounted for ≤5% of bioassay activity, suggesting that detection limits by LC-MS/MS for some chemicals were insufficient and/or other bioactive compounds were present in these samples. Our study demonstrated that in vitro bioassays responses were reproducible, and can provide information to complement conventional analytical methods for a more comprehensive water quality assessment.

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Rapid analysis of trace organic compounds in water by automated online solid-phase extraction coupled to liquid chromatography–tandem mass spectrometry

Cited by 98 publications

References 48 publications

Application of surrogates, indicators, and high-resolution mass spectrometry to evaluate the efficacy of UV processes for attenuation of emerging contaminants in water

Application of surrogates, indicators, and high-resolution mass spectrometry to evaluate the efficacy of UV processes for attenuation of emerging contaminants in water

Use of fluorescence EEM to monitor the removal of emerging contaminants in full scale wastewater treatment plants

Interlaboratory comparison of in vitro bioassays for screening of endocrine active chemicals in recycled water

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